INT59723

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Context Info
Confidence 0.35
First Reported 1993
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 1.31
Pain Relevance 5.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc40a1) plasma membrane (Slc40a1)
Anatomy Link Frequency
brain 2
pons 1
medulla 1
Slc40a1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 22 100.00 Very High Very High Very High
Enkephalin 12 100.00 Very High Very High Very High
medulla 13 98.04 Very High Very High Very High
Inflammation 1 96.40 Very High Very High Very High
Spinal cord 3 95.84 Very High Very High Very High
Immobilon 5 95.44 Very High Very High Very High
MU agonist 8 93.92 High High
Morphine 13 93.88 High High
Opioid 3 93.48 High High
antinociception 9 93.40 High High
Disease Link Frequency Relevance Heat
Hypoxia 1 97.08 Very High Very High Very High
INFLAMMATION 1 96.40 Very High Very High Very High
Targeted Disruption 17 95.52 Very High Very High Very High
Iron Overload 1 70.16 Quite High
Anaemia 10 19.92 Low Low
Hepatocellular Cancer 3 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 3 5.00 Very Low Very Low Very Low
Nociception 2 5.00 Very Low Very Low Very Low
Contagious Ecthyma 2 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adjacent coronal sections were cut from the brains of +/+, +/- and -/- mice for the determination of binding of [3H]CI-977, [3H]DAMGO (D-Ala2-MePhe4-Gly-ol5 enkephalin) or [3H]DELT-I (D-Ala2 deltorphin I) to kappa1-, mu- and delta-receptors, respectively.
ol5 Spec (determination) Binding (binding) of in brains associated with enkephalin
1) Confidence 0.35 Published 1999 Journal Brain Res. Section Abstract Doc Link 10082819 Disease Relevance 0.22 Pain Relevance 0.38
Chronic administration of L-arginine or D-arginine did not alter the Bmax or Kd values of [3H][D-Ala2,MePhe4,Gly5-ol]enkephalin binding to the mouse brain membranes.
MePhe4,Gly5-ol Binding (binding) of in brain associated with enkephalin
2) Confidence 0.07 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9152376 Disease Relevance 0 Pain Relevance 1.66
We now report that the binding of mu-opioid receptor ligand, [3H][D-Ala2,NHPhe4,Gly-ol]enkephalin to membrane preparations of the pons/medulla was reduced by half in heterozygous mu-opioid receptor knockout mice and eliminated in homozygous mu-opioid receptor knockout mice.
NHPhe4,Gly-ol Binding (binding) of in medulla associated with targeted disruption, medulla, enkephalin and opioid receptor
3) Confidence 0.02 Published 1999 Journal Neuroscience Section Abstract Doc Link 10613510 Disease Relevance 0.41 Pain Relevance 1.08
Hepcidin controls systemic iron fluxes by binding to the iron exporter ferroportin, inducing its internalization and degradation [12].
ferroportin Binding (binding) of
4) Confidence 0.01 Published 2010 Journal Biochemical Journal Section Body Doc Link PMC2958558 Disease Relevance 0.26 Pain Relevance 0.05
We now report that the binding of mu-opioid receptor ligand, [3H][D-Ala2,NHPhe4,Gly-ol]enkephalin to membrane preparations of the pons/medulla was reduced by half in heterozygous mu-opioid receptor knockout mice and eliminated in homozygous mu-opioid receptor knockout mice.
NHPhe4,Gly-ol Binding (binding) of in pons associated with targeted disruption, medulla, enkephalin and opioid receptor
5) Confidence 0.01 Published 1999 Journal Neuroscience Section Abstract Doc Link 10613510 Disease Relevance 0.41 Pain Relevance 1.08
The mu-selective ligand [3H][D-Ala2,N-Me-Phe4,Gly5-ol]enkephalin also bound with high affinity (KD = 0.79 nM; Bmax = 108 +/- 17 fmol/mg of protein) to the solubilized material.
Gly5-ol Binding (bound) of associated with enkephalin
6) Confidence 0.00 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8395567 Disease Relevance 0 Pain Relevance 0.92

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