INT59725

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Context Info
Confidence 0.45
First Reported 1993
Last Reported 2010
Negated 4
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 0.83
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
diaphragm 1
skeletal muscle 1
Dap (Rattus norvegicus)
Pain Link Frequency Relevance Heat
addiction 3 93.48 High High
tetrodotoxin 10 93.44 High High
Action potential 20 90.08 High High
Pyramidal cell 2 75.52 Quite High
Spinal cord 4 65.44 Quite High
anesthesia 5 50.00 Quite Low
action potential duration 4 34.84 Quite Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 6 94.56 High High
Syndrome 4 91.20 High High
Cataract 1 81.68 Quite High
Sprains And Strains 2 77.04 Quite High
Fatigue 50 74.80 Quite High
Spinal Cord Injury 4 65.80 Quite High
Aging 2 59.76 Quite High
Muscle Weakness 2 59.24 Quite High
Ocular Hypertension 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Repetitive stimulation at 1-2 Hz did not change the amplitude or decay of the DAP or DAP-like response. 3.
Neg (not) Regulation (change) of DAP
1) Confidence 0.45 Published 1993 Journal J. Neurophysiol. Section Abstract Doc Link 8395576 Disease Relevance 0 Pain Relevance 0.41
Repetitive stimulation at 1-2 Hz did not change the amplitude or decay of the DAP or DAP-like response. 3.
Neg (not) Regulation (change) of DAP
2) Confidence 0.45 Published 1993 Journal J. Neurophysiol. Section Abstract Doc Link 8395576 Disease Relevance 0 Pain Relevance 0.41
Intracellular Ca2+ chelation with the fast chelator, bis-(o-aminophenoxy)-N,N,N',N'-tetraacetic acid (BAPTA), only slightly enhanced the DAP, suggesting that the DAP is not generated by inward currents activated secondary to Ca2+ influx.
Neg (not) Regulation (generated) of DAP
3) Confidence 0.45 Published 1993 Journal J. Neurophysiol. Section Abstract Doc Link 8395576 Disease Relevance 0 Pain Relevance 0.29
The inotropic effects on skeletal muscle of DAP and other aminopyridines has been studied extensively under isometric contractile conditions, during which there is force generation without shortening.
Regulation (effects) of DAP in skeletal muscle
4) Confidence 0.39 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2821379 Disease Relevance 0.57 Pain Relevance 0.03
It is possible (albeit speculative) that the three muscles studied have different proportions of various K+ channel types and subtypes, with the diaphragm having the highest proportion of K+ channel subtypes with high DAP sensitivity.


Regulation (sensitivity) of DAP in diaphragm
5) Confidence 0.24 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2821379 Disease Relevance 0.19 Pain Relevance 0
Decrease of [Ca(2+)](o) did not alter DAP significantly, suggesting a nonessential role of Ca(2+) in the DAP.
Neg (not) Regulation (alter) of DAP
6) Confidence 0.23 Published 2004 Journal Brain Res. Section Abstract Doc Link 15374744 Disease Relevance 0 Pain Relevance 0.27
RESULTS: The mean values for HR, SAP, DAP and IOP measured before and after induction of anaesthesia were not different in both groups.
Regulation (values) of DAP
7) Confidence 0.02 Published 1996 Journal Klin Oczna Section Body Doc Link 9019575 Disease Relevance 0.08 Pain Relevance 0

General Comments

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