INT5973

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Context Info
Confidence 0.62
First Reported 1988
Last Reported 2010
Negated 14
Speculated 15
Reported most in Abstract
Documents 109
Total Number 124
Disease Relevance 66.60
Pain Relevance 39.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL1B) signal transduction (IL1B) extracellular space (IL1B)
aging (IL1B) extracellular region (IL1B) cell-cell signaling (IL1B)
Anatomy Link Frequency
monocytes 4
T-cell 3
macrophages 2
ileum 2
brain 2
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1207 100.00 Very High Very High Very High
cytokine 974 100.00 Very High Very High Very High
antagonist 258 100.00 Very High Very High Very High
agonist 211 100.00 Very High Very High Very High
methotrexate 138 100.00 Very High Very High Very High
cINOD 74 100.00 Very High Very High Very High
Inflammatory mediators 44 100.00 Very High Very High Very High
aspirin 23 100.00 Very High Very High Very High
Inflammatory marker 19 100.00 Very High Very High Very High
diclofenac 15 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1405 100.00 Very High Very High Very High
Cancer 191 100.00 Very High Very High Very High
Depression 162 100.00 Very High Very High Very High
Necrosis 107 100.00 Very High Very High Very High
Fever 47 100.00 Very High Very High Very High
Hypoxia 4 100.00 Very High Very High Very High
Syndrome 239 99.92 Very High Very High Very High
Rheumatoid Arthritis 573 99.84 Very High Very High Very High
Infection 233 99.84 Very High Very High Very High
Arthropathy 25 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of antirheumatic drugs on interleukin 1 (IL-1) activity and IL-1 and IL-1 inhibitor production by human monocytes.
Regulation (effect) of IL-1 in monocytes associated with methotrexate
1) Confidence 0.62 Published 1990 Journal J. Rheumatol. Section Title Doc Link 1981242 Disease Relevance 0.26 Pain Relevance 0.38
Exposure to the VEEV has also induced the up regulation of pro-inflammatory genes such as IL-6, IFN-b, IL-1a, IL1-b and the Fas ligand.
Regulation (regulation) of IL1-b associated with inflammation
2) Confidence 0.60 Published 2007 Journal Virol J Section Body Doc Link PMC2042503 Disease Relevance 0.59 Pain Relevance 0.10
heterodimers), we measured the effects on IL-1?
Regulation (effects) of IL-1
3) Confidence 0.60 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0.06
Opiate regulation of IL-1beta and TNF-alpha in cultured human articular chondrocytes.
Regulation (regulation) of IL-1beta in articular associated with opiate
4) Confidence 0.60 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 15979578 Disease Relevance 0.34 Pain Relevance 0.32
Therefore, we examine SC-specific autoregulation of IL-1alpha, IL-1beta and their natural antagonist IL-1 receptor antagonist (IL-1Ra) during experimental autoimmune neuritis (EAN), a model for the human Guillain-Barre syndrome.
Regulation (autoregulation) of IL-1beta associated with syndrome, experimental autoimmune neuritis, antagonist and neuritis
5) Confidence 0.60 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11311332 Disease Relevance 0.76 Pain Relevance 0.60
Such a regulation of IL-1beta on the ET release and the balance of ETA to ETB receptors leading to a loss of ET-1-induced myometrial cell contractions suggest that complex regulatory mechanisms take place to constraint the onset of infection-induced premature contractions.
Regulation (regulation) of IL-1beta associated with infection
6) Confidence 0.60 Published 2005 Journal Endocrinology Section Abstract Doc Link 16109787 Disease Relevance 0.25 Pain Relevance 0.15
Effects of hyperthermia and muramyl dipeptide on IL-1beta, IL-6, and mortality in a neonatal rat model.
Regulation (Effects) of IL-1beta associated with fever
7) Confidence 0.60 Published 2002 Journal Pediatr. Res. Section Title Doc Link 12438666 Disease Relevance 0.75 Pain Relevance 0.17
We studied the effect of the inflammatory cytokine interleukin-1 beta (IL-1) and several anti-inflammatory drugs on amyloid beta-peptide (A beta) cytotoxicity.
Regulation (effect) of cytokine interleukin-1 beta associated with inflammation, alzheimer's dementia, cinod and cytokine
8) Confidence 0.56 Published 1996 Journal Brain Res. Section Abstract Doc Link 8813406 Disease Relevance 0.37 Pain Relevance 0.34
We studied the effect of the inflammatory cytokine interleukin-1 beta (IL-1) and several anti-inflammatory drugs on amyloid beta-peptide (A beta) cytotoxicity.
Regulation (effect) of IL-1 associated with inflammation, alzheimer's dementia, cinod and cytokine
9) Confidence 0.56 Published 1996 Journal Brain Res. Section Abstract Doc Link 8813406 Disease Relevance 0.37 Pain Relevance 0.34
The production of IL-1Ra in the non-degenerate disc demonstrates a means of regulating IL-1.
Regulation (regulating) of IL-1
10) Confidence 0.55 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175026 Disease Relevance 0.24 Pain Relevance 0.04
Tissue levels of IL-1 beta and IL-6 were not affected after the 400mg dose but decreased significantly (44+/-32% and 38+/-13%) after the 800 mg dose.
Neg (not) Regulation (affected) of IL-1 beta
11) Confidence 0.51 Published 2008 Journal Pain Section Abstract Doc Link 18396374 Disease Relevance 0.98 Pain Relevance 0.80
Schwann cell-specific regulation of IL-1 and IL-1Ra during EAN: possible relevance for immune regulation at paranodal regions.
Regulation (regulation) of IL-1 in Schwann cell
12) Confidence 0.49 Published 2001 Journal J. Neuroimmunol. Section Title Doc Link 11311332 Disease Relevance 0.73 Pain Relevance 0.58
At least in the case of the IL1B promoter, repression did not seem to involve another factor whose activity is affected by the NSAIDs, NFkappaB as the IL1B promoter fragment used in our studies is not NFkappaB responsive and binds specifically to HSF1.
Neg (not) Regulation (responsive) of IL1B associated with repression and cinod
13) Confidence 0.48 Published 1999 Journal Cytokine Section Abstract Doc Link 10328874 Disease Relevance 0.77 Pain Relevance 0.92
The inhibitory effects of two non-steroidal anti-inflammatory drugs (NSAIDS), diclofenac and indomethacin, on interleukin-1 (IL-1)-induced changes in arachidonic acid (AA) release and prostaglandin E2(PGE2) production by human synovial cells was investigated.
Regulation (changes) of interleukin-1 in synovial cells associated with inflammation, cinod and diclofenac
14) Confidence 0.45 Published 1989 Journal Biochem. Pharmacol. Section Abstract Doc Link 2512925 Disease Relevance 0.10 Pain Relevance 0.23
The inhibitory effects of two non-steroidal anti-inflammatory drugs (NSAIDS), diclofenac and indomethacin, on interleukin-1 (IL-1)-induced changes in arachidonic acid (AA) release and prostaglandin E2(PGE2) production by human synovial cells was investigated.
Regulation (changes) of IL-1 in synovial cells associated with inflammation, cinod and diclofenac
15) Confidence 0.45 Published 1989 Journal Biochem. Pharmacol. Section Abstract Doc Link 2512925 Disease Relevance 0.10 Pain Relevance 0.23
The objective of our study was to investigate the effect of a number of representative antirheumatic agents on the activity of IL-1 and the production of both IL-1 and IL-1 inhibitor by human monocytes.
Spec (investigate) Regulation (effect) of IL-1 in monocytes
16) Confidence 0.45 Published 1990 Journal J. Rheumatol. Section Abstract Doc Link 1981242 Disease Relevance 0.26 Pain Relevance 0.26
The effect of antirheumatic drugs on interleukin 1 (IL-1) activity and IL-1 and IL-1 inhibitor production by human monocytes.
Regulation (effect) of interleukin 1 in monocytes associated with methotrexate
17) Confidence 0.45 Published 1990 Journal J. Rheumatol. Section Title Doc Link 1981242 Disease Relevance 0.26 Pain Relevance 0.38
is considered to be dependent on the actual ratio of IL-1?
Regulation (dependent) of IL-1
18) Confidence 0.44 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 0.80 Pain Relevance 0.36
The importance of cytokines, especially TNF-alpha and IL-1beta, are emphasised in the propagation and maintenance of the brain inflammatory response to injury.
Regulation (importance) of IL-1beta in brain associated with inflammatory response, injury and cytokine
19) Confidence 0.44 Published 2000 Journal Expert Opin Investig Drugs Section Abstract Doc Link 11060807 Disease Relevance 1.13 Pain Relevance 0.43
Tissue (lung, spleen, and heart) content of IL-1beta was increased by LPS but was not affected by HEM.
Neg (not) Regulation (affected) of IL-1beta in heart
20) Confidence 0.44 Published 2000 Journal Life Sci. Section Abstract Doc Link 10670828 Disease Relevance 0.41 Pain Relevance 0.44

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