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Context Info
Confidence 0.20
First Reported 1993
Last Reported 1993
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.14
Pain Relevance 0.16

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plasma membrane (Glp1r) signal transducer activity (Glp1r)
Glp1r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 1 79.96 Quite High
agonist 1 79.56 Quite High
Neuropeptide 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Hypoglycemia 2 92.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, 1) high levels of gene expression and secretion of NPY are found in a rat insulinoma cell line (INS-1). 2) Accumulation of cAMP induced by forskolin or a gluco-incretin (GLP-1) induces a further increase in NPY gene expression and release. 3) NPY secretion is not modulated by low or high glucose concentrations in the medium. 4) Induction of NPY, a known inhibitor of insulin secretion, may represent a novel counterregulatory mechanism of insulin secretion, limiting the stimulatory effect of GLP-1 on insulin secretion.
Negative_regulation (limiting) of Negative_regulation (effect) of GLP-1 associated with hypoglycemia
1) Confidence 0.20 Published 1993 Journal Endocrinology Section Abstract Doc Link 8396008 Disease Relevance 0.14 Pain Relevance 0.16

General Comments

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