INT59738

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Context Info
Confidence 0.20
First Reported 1993
Last Reported 1993
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.14
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Glp1r) signal transducer activity (Glp1r)
Glp1r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 1 79.96 Quite High
agonist 1 79.56 Quite High
Neuropeptide 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Hypoglycemia 2 92.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, 1) high levels of gene expression and secretion of NPY are found in a rat insulinoma cell line (INS-1). 2) Accumulation of cAMP induced by forskolin or a gluco-incretin (GLP-1) induces a further increase in NPY gene expression and release. 3) NPY secretion is not modulated by low or high glucose concentrations in the medium. 4) Induction of NPY, a known inhibitor of insulin secretion, may represent a novel counterregulatory mechanism of insulin secretion, limiting the stimulatory effect of GLP-1 on insulin secretion.
Negative_regulation (limiting) of Negative_regulation (effect) of GLP-1 associated with hypoglycemia
1) Confidence 0.20 Published 1993 Journal Endocrinology Section Abstract Doc Link 8396008 Disease Relevance 0.14 Pain Relevance 0.16

General Comments

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