INT59766

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Context Info
Confidence 0.50
First Reported 1993
Last Reported 2004
Negated 2
Speculated 1
Reported most in Abstract
Documents 9
Total Number 12
Disease Relevance 1.31
Pain Relevance 11.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Oprm1)
Anatomy Link Frequency
neurons 6
pituitary 2
nucleus 2
Oprm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 91 100.00 Very High Very High Very High
agonist 30 100.00 Very High Very High Very High
narcan 10 100.00 Very High Very High Very High
antiallodynic 1 99.96 Very High Very High Very High
Morphine 30 99.90 Very High Very High Very High
Enkephalin 6 99.08 Very High Very High Very High
Locus ceruleus 9 98.68 Very High Very High Very High
Kinase C 12 98.28 Very High Very High Very High
potassium channel 3 98.16 Very High Very High Very High
opiate 2 96.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bordatella Infection 2 94.08 High High
Neuropathic Pain 7 89.68 High High
Nociception 4 75.00 Quite High
Pain 4 75.00 Quite High
Injury 1 73.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that chronic blockade of the mu receptor with naloxone may induce a functional supersensitivity to the effects of mu- but not to those of kappa-agonists on the hypothalamus-pituitary-adrenocortical axis.
Neg (not) Spec (may) Positive_regulation (induce) of Negative_regulation (blockade) of mu receptor in pituitary associated with agonist and narcan
1) Confidence 0.50 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8396640 Disease Relevance 0 Pain Relevance 0.86
Thus, activation of Gq-coupled M3 muscarinic receptors or application of a phorbol ester enhanced the desensitization of the mu-opioid receptor-evoked potassium current in rat locus ceruleus neurons.
Positive_regulation (enhanced) of Negative_regulation (desensitization) of mu-opioid receptor in neurons associated with locus ceruleus and opioid receptor
2) Confidence 0.47 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15361548 Disease Relevance 0 Pain Relevance 1.22
Moreover, we demonstrated that the selective blockade of mu-opioid receptor by cyprodime (CP) enhanced antiallodynic effect of SHU9119 as well as pronociceptive action of MTII, whereas the combined administration of mu receptor agonist (DAMGO) and SHU9119 significantly reduced the analgesic effect of those ligands.
Positive_regulation (enhanced) of Negative_regulation (blockade) of mu-opioid receptor associated with analgesic, agonist, opioid receptor and antiallodynic
3) Confidence 0.47 Published 2002 Journal Neuroreport Section Abstract Doc Link 12499847 Disease Relevance 0.76 Pain Relevance 1.53
We have recently identified the serine residues, Ser(261) and Ser(266), within the third intracellular loop as two consensus calcium/calmodulin-dependent protein kinase II (CaMKII) sites required for agonist-induced phosphorylation and desensitization of the mu-opioid receptor in HEK 293 cells.
Positive_regulation (required) of Negative_regulation (desensitization) of mu-opioid receptor associated with agonist and opioid receptor
4) Confidence 0.45 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11146127 Disease Relevance 0.20 Pain Relevance 1.07
We have recently identified the serine residues, Ser(261) and Ser(266), within the third intracellular loop as two consensus calcium/calmodulin-dependent protein kinase II (CaMKII) sites required for agonist-induced phosphorylation and desensitization of the mu-opioid receptor in HEK 293 cells.
Positive_regulation (induced) of Negative_regulation (desensitization) of mu-opioid receptor associated with agonist and opioid receptor
5) Confidence 0.45 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11146127 Disease Relevance 0.20 Pain Relevance 1.06
Chronic treatment with agonists selective for the mu-opioid receptor, [D-Ala2, N-MePhe4, Gy-ol5]enkephalin (DAMGO), morphine and fentanyl, time- and dose-dependently induced down-regulation of the mu-opioid receptor.
Positive_regulation (induced) of Negative_regulation (down-regulation) of mu-opioid receptor associated with agonist, enkephalin, opioid receptor and morphine
6) Confidence 0.41 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9600641 Disease Relevance 0.16 Pain Relevance 0.68
Recent studies have shown that morphine, in contrast to other agonists at the mu-opioid receptor, causes very little rapid mu-opioid receptor desensitization or internalization in adult rat mammalian neurons, raising important questions about how morphine tolerance is induced.
Positive_regulation (causes) of Neg (little) Negative_regulation (desensitization) of mu-opioid receptor in neurons associated with tolerance, agonist, opioid receptor and morphine
7) Confidence 0.41 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15361548 Disease Relevance 0 Pain Relevance 0.88
This is the first finding that morphine can induce rapid mu-opioid receptor desensitization in adult rat neurons, and because reduced protein kinase C activity in vivo attenuates morphine tolerance, we propose that G-protein coupled receptor cross-talk and the level of protein kinase C activity may play critical roles in the desensitization of the mu-opioid receptor and could underlie the development of morphine tolerance.
Positive_regulation (induce) of Negative_regulation (desensitization) of mu-opioid receptor in neurons associated with kinase c, tolerance, opioid receptor and morphine
8) Confidence 0.41 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15361548 Disease Relevance 0 Pain Relevance 1.43
Our results suggest that a feedback signal emanating from the MAPK cascade is required for mu-opioid receptor desensitization.
Positive_regulation (required) of Negative_regulation (desensitization) of mu-opioid receptor associated with opioid receptor
9) Confidence 0.15 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9575195 Disease Relevance 0 Pain Relevance 0.60
A mitogen-activated protein kinase pathway is required for mu-opioid receptor desensitization.
Positive_regulation (required) of Negative_regulation (desensitization) of mu-opioid receptor associated with enkephalin and opioid receptor
10) Confidence 0.15 Published 1998 Journal J. Biol. Chem. Section Title Doc Link 9575195 Disease Relevance 0 Pain Relevance 0.78
Activation of the MAPK cascade in turn may not only relay mitogenic signals to the nucleus but also trigger initial events leading to phosphorylation and desensitization of the mu-opioid receptor.
Positive_regulation (leading) of Negative_regulation (desensitization) of mu-opioid receptor in nucleus associated with opioid receptor
11) Confidence 0.08 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10617147 Disease Relevance 0 Pain Relevance 0.59
This coexpression led to a faster time course of agonist-induced desensitization of the mu-opioid receptor.
Positive_regulation (induced) of Negative_regulation (desensitization) of mu-opioid receptor associated with agonist and opioid receptor
12) Confidence 0.06 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9326307 Disease Relevance 0 Pain Relevance 0.38

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