INT59768

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Context Info
Confidence 0.45
First Reported 1993
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 4.64
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (TFAM) nucleus (TFAM) DNA binding (TFAM)
Anatomy Link Frequency
finger 1
chromaffin cells 1
TFAM (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 65 99.68 Very High Very High Very High
Kinase C 1 99.40 Very High Very High Very High
Enkephalin 11 98.32 Very High Very High Very High
medulla 1 87.92 High High
Inflammatory marker 1 73.16 Quite High
Spinal cord 5 52.24 Quite High
Inflammation 9 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dengue Hemorrhagic Fever 67 99.84 Very High Very High Very High
Multiple Sclerosis 69 99.68 Very High Very High Very High
Dengue 63 98.64 Very High Very High Very High
Diabetes Mellitus 91 98.24 Very High Very High Very High
Disease 76 97.64 Very High Very High Very High
Colon Cancer 4 96.84 Very High Very High Very High
Endometroid Carcinoma 36 96.76 Very High Very High Very High
Hyperplasia 1 88.24 High High
Hypersensitivity 2 83.28 Quite High
Endometrial Cancer 9 81.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The down-regulation of mtTFA was also reported to be significantly associated with the disease progress of colorectal cancer [9].
Regulation (regulation) of mtTFA associated with colon cancer and disease
1) Confidence 0.45 Published 2010 Journal Virchows Arch Section Body Doc Link PMC2852529 Disease Relevance 0.72 Pain Relevance 0
Participants in the CR and CREX groups had increased expression of genes encoding proteins involved in mitochondrial function such as PPARGC1A, TFAM, eNOS, SIRT1, and PARL (all, p < 0.05).
Regulation (involved) of TFAM
2) Confidence 0.41 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1808482 Disease Relevance 0.21 Pain Relevance 0
TCF2, CXCL10, and FUT4 were all up regulated in the MS samples whereas CDC5L, TNFRSF19 and HLA-DR were down regulated (Table 5).
Regulation (regulated) of TCF2 associated with multiple sclerosis
3) Confidence 0.05 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 0.48 Pain Relevance 0.24
The OUT component is enriched with 'incoming' interactions such as transcription factor target.
Regulation (target) of transcription factor
4) Confidence 0.02 Published 2008 Journal BMC Biol Section Body Doc Link PMC2645369 Disease Relevance 0 Pain Relevance 0.03
The transmembrane protein vezatin and the transcription factor similar to zinc finger protein 91 were significantly up-regulated in DSS patients relative to both DF as well as DHF patients.
Regulation (regulated) of transcription factor in finger associated with dengue and dengue hemorrhagic fever
5) Confidence 0.01 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2886038 Disease Relevance 1.97 Pain Relevance 0.04
Most speculatively, it seems logical that changes in a transcription factor like TCF7L2 will lead to altered expression of other genes and not TCF7L2 itself.
Spec (seems) Regulation (changes) of transcription factor
6) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719801 Disease Relevance 0.82 Pain Relevance 0
These results suggest that regulation of the enkephalin gene in primary chromaffin cells by the calcium, protein kinase A, and protein kinase C signaling pathways occurs by modulation of transcription factor activity at several discrete loci on the enkephalin gene.
Regulation (modulation) of transcription factor in chromaffin cells associated with kinase c and enkephalin
7) Confidence 0.00 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8396715 Disease Relevance 0.08 Pain Relevance 0.78
It is also noted in Table 1 that the miR-17-92 cluster targets E2F1, a member of the E2F transcription factor family.
Regulation (targets) of transcription factor
8) Confidence 0.00 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.36 Pain Relevance 0

General Comments

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