INT59784

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Context Info
Confidence 0.47
First Reported 1993
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 22
Total Number 23
Disease Relevance 19.48
Pain Relevance 2.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DES) cytoskeleton (DES) intracellular (DES)
cytoskeleton organization (DES) cytoplasm (DES)
Anatomy Link Frequency
smooth muscle 4
erythrocytes 1
muscle 1
collars 1
neuron 1
DES (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 14 99.06 Very High Very High Very High
Pain 7 97.00 Very High Very High Very High
Inflammation 29 96.64 Very High Very High Very High
Dismenorea 10 95.36 Very High Very High Very High
cva 7 87.04 High High
B1 receptor 1 82.64 Quite High
antagonist 5 82.16 Quite High
b2 receptor 1 80.56 Quite High
positron emission tomography 16 80.24 Quite High
metalloproteinase 3 77.04 Quite High
Disease Link Frequency Relevance Heat
Disease 108 100.00 Very High Very High Very High
Cancer 496 99.90 Very High Very High Very High
Carcinoma 30 99.78 Very High Very High Very High
Infection 62 98.94 Very High Very High Very High
Dilated Cardiomyopathy 40 98.52 Very High Very High Very High
Endometrial Cancer 9 98.00 Very High Very High Very High
Necrosis 20 97.24 Very High Very High Very High
Pain 7 97.00 Very High Very High Very High
Anaplasia 3 96.76 Very High Very High Very High
INFLAMMATION 30 96.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The carboxy terminus has an intermediate filament binding domain that promotes interactions with desmin intermediate filaments, vimentin, and cytokeratins [39].
desmin Binding (interactions) of in filaments
1) Confidence 0.47 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2868981 Disease Relevance 0 Pain Relevance 0
DCM exhibits high genetic heterogeneity as mutations in > 20 genes have been associated with the disease, such as desmin, tafazzin, ?
desmin Binding (associated) of associated with dilated cardiomyopathy and disease
2) Confidence 0.36 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2630295 Disease Relevance 1.64 Pain Relevance 0.06
The expression patterns of desmin are comparable to the global expression pattern observed on staining for ?
desmin Binding (comparable) of
3) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.52 Pain Relevance 0.04
Immunohistochemical analysis performed on paraffin-embedded tissue sections was negative for pan-cytokeratin 7 and 20, epithelial membrane antigen (EMA), as well as a smooth muscle actin, desmin, CD34 and CD68.
desmin Binding (actin) of in smooth muscle
4) Confidence 0.36 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2843711 Disease Relevance 0.91 Pain Relevance 0
On the other hand, she was negative for cytokeratin, epithelial membrane antigen, desmin, Myo D-1, myogenin and smooth muscle actin.
desmin Binding (cytokeratin) of in smooth muscle
5) Confidence 0.36 Published 2010 Journal J Med Case Reports Section Abstract Doc Link PMC2848680 Disease Relevance 1.02 Pain Relevance 0
The spindle cells displayed cytoplasmic immunoreactivity for vimentin, desmin, panmuscle actin (HHF-35), and alpha-smooth-muscle actin, but were nonreactive for keratin (AE1/AE3), epithelial membrane antigen, and S-100 protein.
desmin Binding (immunoreactivity) of in muscle
6) Confidence 0.36 Published 1993 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 8396855 Disease Relevance 0.85 Pain Relevance 0.08
The spindle cells were found to be positive for vimentin and smooth muscle actin and negative for desmin, S-100 protein, myogenin and CD68 on immunohistochemistry.
desmin Binding (negative) of in smooth muscle
7) Confidence 0.36 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2873452 Disease Relevance 0.68 Pain Relevance 0
Immunohistochemical staining is positive for vimentin only and negative with a variety of antibodies, such as desmin, keratin, S100 protein, epithelial membrane antigen, CD34, and CD31.
desmin Binding (negative) of
8) Confidence 0.36 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2920234 Disease Relevance 1.07 Pain Relevance 0
To compare the stage of peptide action between the VIKI-PEG4-chol and the other two peptides (Figure 6), cells co-expressing HPIV3 F-csm and T193A HPIV3 HN were allowed to bind erythrocytes (RBCs) at 4°C.
csm Binding (bind) of in erythrocytes
9) Confidence 0.36 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2965769 Disease Relevance 0 Pain Relevance 0
and CD99, and are also variably positive for Bcl-2; usually cytokeratins and desmin are negative.9
desmin Binding (negative.9) of
10) Confidence 0.36 Published 2010 Journal Rare Tumors Section Body Doc Link PMC2994496 Disease Relevance 0.93 Pain Relevance 0.16
KS tumor cells were immunoreactive for the vascular markers CD34 and CD31, for the lymphatic endothelial marker D2-40, positive for the HHV8 marker LNA-1, and demonstrated no staining with actin, desmin, cytokeratin cocktail, epithelial membrane antigen and S-100.
desmin Neg (no) Binding (staining) of associated with kaposis sarcoma and cancer
11) Confidence 0.36 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2538530 Disease Relevance 1.38 Pain Relevance 0
After 14 days of culture, the presence of chimeric human/murine myotubes was evaluated by immunostaining for desmin, slow myosin heavy chain (MyHCs) and human lamin A/C.
desmin Binding (immunostaining) of in myotubes
12) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0.29 Pain Relevance 0.03
Immunohistochemically, all tumors tested were reactive with actin, desmin and HMB-45, with the latter being more intensely positive in the subepithelial collars.
desmin Binding (reactive) of in collars associated with cancer
13) Confidence 0.36 Published 2006 Journal Mod. Pathol. Section Abstract Doc Link 16528375 Disease Relevance 1.26 Pain Relevance 0.06
Studies about changes in protein intensities were complemented by an analysis of protein phosphorylation that revealed infection-associated changes in the phosphorylation of myosin binding protein C, atrial and ventricular isoforms of myosin regulatory light chain 2, desmin, and Rab GDP dissociation inhibitor beta-2.
desmin Binding (binding) of associated with infection
14) Confidence 0.36 Published 2010 Journal Proteomics Section Abstract Doc Link 20213679 Disease Relevance 0.98 Pain Relevance 0.05
The tumor was negative for desmin, S-100, CD 34 and c-kit (CD117) but focally positive for actin on immunohistochemistry (IHC).
desmin Binding (negative) of associated with cancer
15) Confidence 0.36 Published 2005 Journal World J Surg Oncol Section Body Doc Link PMC546237 Disease Relevance 0.94 Pain Relevance 0
The spindle cells stain positively for smooth muscle actin and vimentin but are negative for S100, desmin, CD100, cytokeratin, CD35 and latent membrane protein.
desmin Binding (negative) of in smooth muscle
16) Confidence 0.36 Published 2005 Journal World J Surg Oncol Section Body Doc Link PMC1097763 Disease Relevance 1.88 Pain Relevance 0.32
Immunohistochemistry showed strong positivity for SMA and desmin in the spindle cell areas.
desmin Binding (positivity) of
17) Confidence 0.36 Published 2005 Journal Int Semin Surg Oncol Section Body Doc Link PMC1215508 Disease Relevance 0.76 Pain Relevance 0.04
Immunohistochemistry showed strong and diffuse positivity for synaptophysin, chromogranin (Figure 1c), cytokeratin (Figure 1d) Bcl-2 protein and neuron-specific enolase (NSE) but negativity for S100, desmin and epithelial membrane antigen (EMA).
desmin Neg (negativity) Binding (negativity) of in neuron
18) Confidence 0.36 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1971059 Disease Relevance 1.16 Pain Relevance 0
and CD99, and are also variably positive for Bcl-2; usually cytokeratins and desmin are negative.9
desmin Binding (cytokeratins) of
19) Confidence 0.36 Published 2010 Journal Rare Tumors Section Body Doc Link PMC2994496 Disease Relevance 0.93 Pain Relevance 0.16
In the remaining 18 cases with myoinvasive carcinoma, the cells surrounding the carcinomas failed to react with desmin and caldesmon.
desmin Neg (failed) Binding (react) of associated with carcinoma
20) Confidence 0.35 Published 2003 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 12766582 Disease Relevance 1.60 Pain Relevance 0.54

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