INT5979

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Context Info
Confidence 0.78
First Reported 1974
Last Reported 2010
Negated 2
Speculated 18
Reported most in Abstract
Documents 428
Total Number 446
Disease Relevance 75.64
Pain Relevance 320.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)
Anatomy Link Frequency
brain 22
neurons 21
spinal cord 11
immune cells 10
CHO 10
Oprd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 4609 100.00 Very High Very High Very High
Opioid 4071 100.00 Very High Very High Very High
analgesia 1302 100.00 Very High Very High Very High
Pain 1114 100.00 Very High Very High Very High
agonist 976 100.00 Very High Very High Very High
antinociception 885 100.00 Very High Very High Very High
Endogenous opioid 872 100.00 Very High Very High Very High
Enkephalin 814 100.00 Very High Very High Very High
Analgesic 607 100.00 Very High Very High Very High
antagonist 605 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 303 100.00 Very High Very High Very High
Urological Neuroanatomy 202 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 13 100.00 Very High Very High Very High
Stress 490 99.92 Very High Very High Very High
Death 53 99.92 Very High Very High Very High
Malignant Neoplastic Disease 11 99.88 Very High Very High Very High
Neuroblastoma 58 99.86 Very High Very High Very High
Nociception 346 99.84 Very High Very High Very High
Disease 174 99.84 Very High Very High Very High
Pain 1153 99.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, no significant change was observed in the delta-opioid receptor mRNA expression throughout the laminae I-IX at any time points examined.
Gene_expression (expression) of delta-opioid receptor mRNA associated with opioid receptor
1) Confidence 0.78 Published 1996 Journal Pain Section Abstract Doc Link 8740615 Disease Relevance 0.15 Pain Relevance 0.50
Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications.
Gene_expression (expression) of Opioid-receptor mRNA associated with opioid
2) Confidence 0.78 Published 1995 Journal Trends Neurosci. Section Title Doc Link 7535487 Disease Relevance 0.08 Pain Relevance 0.54
The present data suggested that the central, but not peripheral, plasticity triggered by inflammation-induced facilitation of A(beta) fibers plays an important role in morphine-induced alleviation of allodynia, whereas activation of opioid receptor expression on the peripheral terminals of C fibers may contribute to morphine-induced alleviation of persistent pain of inflammation.
Gene_expression (expression) of opioid receptor associated with pain, allodynia, inflammation, lasting pain, opioid receptor and morphine
3) Confidence 0.78 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14642787 Disease Relevance 0.76 Pain Relevance 1.14
Alternatively, both opioid receptor and peptide expression in the caudate-putamen may be directly, but independently, regulated by ventral mesencephalic neurons.
Gene_expression (expression) of opioid receptor in neurons associated with opioid receptor
4) Confidence 0.76 Published 1993 Journal Neuroscience Section Abstract Doc Link 8232904 Disease Relevance 0 Pain Relevance 0.67
The significance of depolarization and voltage-dependent sodium and calcium channels on the expression of different opioid receptor subtypes is discussed.
Gene_expression (expression) of opioid receptor associated with calcium channel and opioid receptor
5) Confidence 0.76 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2535711 Disease Relevance 0.17 Pain Relevance 0.42
There is therefore a broad, but tissue specific distribution of opioid receptor expression in the periphery of the rat, suggesting that the endogenous opioid peptides play an endocrine, paracrine, or autocrine role in the regulation of physiology at a peripheral as well as central level.
Gene_expression (expression) of opioid receptor associated with endogenous opioid and opioid receptor
6) Confidence 0.76 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8579608 Disease Relevance 0 Pain Relevance 0.50
Opioid receptor expression was not detected in endothelium or synovium.
Gene_expression (expression) of Opioid receptor in synovium associated with opioid receptor
7) Confidence 0.76 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8579608 Disease Relevance 0 Pain Relevance 0.51
Tissue distribution of opioid receptor gene expression in the rat.
Gene_expression (expression) of opioid receptor associated with opioid receptor
8) Confidence 0.76 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 8579608 Disease Relevance 0 Pain Relevance 0.45
METHODS AND RESULTS: Opioid receptor expression in hearts from hypertensive and normotensive rats was studied during heart development by binding assays.
Gene_expression (expression) of Opioid receptor in hearts
9) Confidence 0.74 Published 1996 Journal Circulation Section Body Doc Link 8598065 Disease Relevance 0.10 Pain Relevance 0
Using this procedure, the data suggest that the NMB neuroblastoma cells express the three opioid receptor types with the abundance of delta receptors (about 60%) and minor, yet substantial populations of mu and kappa receptors (about 20% each).
Gene_expression (express) of opioid receptor associated with neuroblastoma and opioid receptor
10) Confidence 0.74 Published 1993 Journal Life Sci. Section Abstract Doc Link 8387137 Disease Relevance 0.26 Pain Relevance 0.22
Opioid receptor gene expression in the rat brain during ontogeny, with special reference to the mesostriatal system: an in situ hybridization study.
Gene_expression (expression) of Opioid receptor gene in brain associated with opioid receptor
11) Confidence 0.74 Published 1998 Journal Brain Res. Dev. Brain Res. Section Title Doc Link 9729374 Disease Relevance 0 Pain Relevance 0.56
It was hypothesized that the presence or lack thereof of gonadal hormones would alter nociception, an effect temporally correlated with a change in opioid receptor protein expression.
Gene_expression (expression) of opioid receptor protein in gonadal associated with nociception and opioid receptor
12) Confidence 0.73 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18054782 Disease Relevance 0.90 Pain Relevance 0.61
Animal studies support these findings and demonstrate that chronic cocaine administration can result in alterations in opioid receptor expression and function as measured by changes in critical signal transduction pathways.
Gene_expression (expression) of opioid receptor associated with opioid receptor and cocaine
13) Confidence 0.73 Published 2001 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 11458541 Disease Relevance 0.09 Pain Relevance 0.66
It is suggested that the observed clinical phenomena in response to morphine can be explained by differences in expression and sensitivity of some opioid receptor subtypes in migraine.
Gene_expression (expression) of opioid receptor associated with migraine, opioid receptor and morphine
14) Confidence 0.73 Published 1996 Journal Cephalalgia Section Abstract Doc Link 8869763 Disease Relevance 0.60 Pain Relevance 1.08
Inflammation not only increases the opioid receptor expression in DRG neurons but also enhances transport and accumulation of opioid receptors on the peripheral terminals of sensory neurons.
Gene_expression (expression) of opioid receptor in sensory neurons associated with inflammation and opioid receptor
15) Confidence 0.73 Published 2003 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 12617566 Disease Relevance 0.34 Pain Relevance 0.87
In addition, as some conditions associated with cholestasis and bile ductular proliferation can be complicated by malignancy, the expression of the delta opioid receptor in malignant tumors of the biliary tree merits research.
Gene_expression (expression) of delta opioid receptor in biliary tree associated with malignant neoplastic disease, bile, opioid receptor and gallstones
16) Confidence 0.69 Published 2005 Journal Med. Hypotheses Section Abstract Doc Link 16125331 Disease Relevance 0.84 Pain Relevance 1.07
Preliminary data presented in this manuscript reveals the expression of the delta opioid receptor in the liver of rats with cholestasis.
Gene_expression (expression) of delta opioid receptor in liver associated with opioid receptor and gallstones
17) Confidence 0.69 Published 2005 Journal Med. Hypotheses Section Abstract Doc Link 16125331 Disease Relevance 0.64 Pain Relevance 1.23
The delta opioid receptor 1 is expressed by proliferating bile ductules in rats with cholestasis: implications for the study of liver regeneration and malignant transformation of biliary epithelium.
Gene_expression (expressed) of delta opioid receptor in liver associated with malignant neoplastic disease, bile, opioid receptor 1 and gallstones
18) Confidence 0.69 Published 2005 Journal Med. Hypotheses Section Title Doc Link 16125331 Disease Relevance 0.53 Pain Relevance 0.97
Northern blot analysis showed that expression of mu-opioid receptor mRNA was intensive in the thalamus, striatum, hypothalamus and pons-medulla, moderate in the hippocampus and midbrain, and slight in the cerebral cortex and cerebellum.
Gene_expression (expression) of mu-opioid receptor mRNA in hypothalamus associated with medulla, midbrain, hippocampus, thalamus, opioid receptor and cerebral cortex
19) Confidence 0.68 Published 1994 Journal Neurosci. Res. Section Abstract Doc Link 8190373 Disease Relevance 0.06 Pain Relevance 0.81
Intense expression of mu-opioid receptor mRNA was observed in the internal granular and glomerular layers of the olfactory bulb, caudate putamen, nucleus accumbens, medial septum, diagonal band, medial preoptic area, several nuclei of thalamus, amygdala, interpeduncular nucleus, medial raphe nucleus, inferior colliculus, parabrachial nucleus, locus coeruleus, nucleus solitary tract and ambiguus nucleus.
Gene_expression (expression) of mu-opioid receptor mRNA in preoptic area associated with locus ceruleus, thalamus, opioid receptor, parabrachial, nucleus accumbens, urological neuroanatomy, amygdala and raphe
20) Confidence 0.68 Published 1994 Journal Neurosci. Res. Section Abstract Doc Link 8190373 Disease Relevance 0.09 Pain Relevance 0.94

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