INT59790

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Context Info
Confidence 0.36
First Reported 1993
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 15.34
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (BCR) signal transduction (BCR) plasma membrane (BCR)
kinase activity (BCR)
Anatomy Link Frequency
B-cells 3
PHL 2
lung 1
T-cell 1
BCR (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 5 99.84 Very High Very High Very High
Osteoarthritis 78 96.20 Very High Very High Very High
Sumatriptan 1 96.00 Very High Very High Very High
Action potential 2 94.72 High High
ergotamine 1 94.20 High High
cINOD 19 90.04 High High
antidepressant 1 89.44 High High
fluoxetine 1 88.24 High High
Inflammation 27 81.04 Quite High
unmyelinated 2 72.88 Quite High
Disease Link Frequency Relevance Heat
Leukemia 635 100.00 Very High Very High Very High
Pulmonary Disease 56 100.00 Very High Very High Very High
Headache 8 99.84 Very High Very High Very High
Acute Myeloid Leukemia 56 99.48 Very High Very High Very High
Disease 74 99.46 Very High Very High Very High
Chronic Lymphoid Leukemia 7 99.40 Very High Very High Very High
Lymphatic System Cancer 166 99.36 Very High Very High Very High
Hodgkin's Disease 526 99.08 Very High Very High Very High
Apoptosis 9 97.12 Very High Very High Very High
Frailty 68 96.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This most frequently has a molecular weight of 210 kD (p210Bcr/Abl) and has increased tyrosine kinase activity which is essential to its transforming capability.1,2 Imatinib mesylate is a potent and selective tyrosine kinase inhibitor that has become standard therapy for patients with CML in all stages of the disease.2 A complete cytogenetic response (CGCR) can be achieved in 50% to 60% of patients treated in chronic phase (CP) after failure with interferon alpha (IFN-?)
Bcr Binding (weight) of associated with myeloid leukemia and disease
1) Confidence 0.36 Published 2010 Journal Core evidence Section Body Doc Link PMC2899790 Disease Relevance 0.61 Pain Relevance 0
The four acute anti-migraine agents interacted with all 4 human 5-HT1 receptor subtypes with less than 1 microM affinity.
all Binding (interacted) of associated with migraine
2) Confidence 0.35 Published 1993 Journal Headache Section Abstract Doc Link 8397171 Disease Relevance 0.34 Pain Relevance 0.55
Here, we show that lymphoma cells protected from apoptosis by expression of a bcl-2 transgene or by virtue of the t(14;18)(q32;q21) translocation continue to register enhanced AV binding in response to BCR crosslinking.
BCR Binding (crosslinking) of associated with lymphatic system cancer and apoptosis
3) Confidence 0.35 Published 2006 Journal Leuk. Res. Section Abstract Doc Link 16076491 Disease Relevance 0.59 Pain Relevance 0.13
Paternal use of any pesticide was significantly associated with T-cell ALL (OR = 3.6; 95% CI, 1.2–10.0).
ALL Binding (associated) of in T-cell associated with leukemia
4) Confidence 0.28 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137105 Disease Relevance 1.79 Pain Relevance 0
In all three studies, at least one household pesticide exposure was significantly associated with childhood lymphoma.
all Binding (associated) of associated with lymphatic system cancer
5) Confidence 0.28 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137105 Disease Relevance 1.10 Pain Relevance 0
Infante-Rivard et al. (1999) observed significant associations between ALL and parental use of indoor insecticides during pregnancy, indoor plant insecticides (OR = 2.0; 95% CI, 1.3–2.9), outdoor herbicides (OR = 1.8; 95% CI, 1.3–2.6), and products for trees (OR = 1.7; 95% CI, 1.1–2.6).
ALL Binding (associations) of associated with leukemia
6) Confidence 0.27 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137105 Disease Relevance 0.44 Pain Relevance 0
The results were quite similar for the lymphoblastic (ALL) and the myeloblastic (AML) subtypes of AL, but the associations were less clear for T-cell ALL (67 cases) than for common B-cell ALL (544 cases).
ALL Spec (clear) Binding (associations) of in B-cell associated with leukemia and acute myeloid leukemia
7) Confidence 0.27 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137105 Disease Relevance 2.12 Pain Relevance 0
Relatively similar associations with ALL and acute non-lymphoblastic leukemia were reported in each study (Lowengart et al. 1987; Ma et al. 2002; Menegaux et al. 2006).
ALL Binding (associations) of associated with chronic lymphoid leukemia and leukemia
8) Confidence 0.27 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137105 Disease Relevance 1.46 Pain Relevance 0
Buckley et al. (2000) found quite similar positive associations for all subtypes of childhood NHL.
all Binding (associations) of associated with hodgkin's disease
9) Confidence 0.27 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137105 Disease Relevance 1.44 Pain Relevance 0
Stratified analyses showed that the associations between ALL and maternal household use of any pesticide during pregnancy were stable across the different age groups.
ALL Binding (associations) of associated with leukemia
10) Confidence 0.27 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137105 Disease Relevance 1.79 Pain Relevance 0
All types of afferent fibers present in adult mice could readily be recognized in mice at postnatal day 14.
All Binding (recognized) of
11) Confidence 0.27 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9325353 Disease Relevance 0.40 Pain Relevance 0.19
Human blood B cells highly express Cox-2 mRNA and protein and produce PGs after activation with CD40L, pansorbin, or CD40L plus BCR engagement.
BCR Binding (engagement) of in B cells
12) Confidence 0.20 Published 2005 Journal J. Immunol. Section Abstract Doc Link 15728468 Disease Relevance 0.37 Pain Relevance 0.42
Its known mechanisms of action differ from the anti-CD20 monoclonal antibody which depletes very efficiently CD20+ B-cells, rituximab, by CD22 phosphorylation (Carnahan et al 2003) and by affecting BCR (via immobilized immunoglobulin crosslinking), as well as inducing moderate, but significant, ADCC, without showing direct apoptotic or complement-mediated killing (Carnahan et al 2003).
BCR Binding (crosslinking) of in B-cells associated with apoptosis
13) Confidence 0.17 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376077 Disease Relevance 0.91 Pain Relevance 0
Hebetudo can apply to all three faculties; Platter, not quite in line with the tripartite faculty psychology of the time but echoing Gregor Reisch, labels these as “apprehension or ingenium [standing in for “imagination”], judgement or reason, and memory”.
all Binding (apply) of
14) Confidence 0.12 Published 2004 Journal Medical History Section Body Doc Link PMC547918 Disease Relevance 0.51 Pain Relevance 0
Both studies have assessed the complex PHL, which has been used at the same daily dose (equivalent of 540?
PHL Binding (complex) of in PHL
15) Confidence 0.05 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538506 Disease Relevance 0.53 Pain Relevance 0.22
Both studies have assessed the complex PHL, which has been used at the same daily dose (equivalent of 540?
PHL Binding (used) of in PHL
16) Confidence 0.05 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538506 Disease Relevance 0.53 Pain Relevance 0.22
Although there was no significant difference in the primary outcome of the proportion of patients with exacerbations that required treatment with systemic steroids or antibiotics, other outcomes including lung function, disease-specific quality of life, hospitalizations for COPD, and all-cause hospitalization favored treatment with tiotropium plus salmeterol plus fluticasone compared with tiotropium plus placebo.
all-cause Binding (hospitalizations) of in lung associated with pulmonary disease and disease
17) Confidence 0.03 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695619 Disease Relevance 0.40 Pain Relevance 0

General Comments

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