INT59795

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Context Info
Confidence 0.43
First Reported 1993
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 5
Total Number 11
Disease Relevance 4.43
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tfrc) peptidase activity (Tfrc) mitochondrion (Tfrc)
aging (Tfrc) extracellular region (Tfrc) cytoplasmic membrane-bounded vesicle (Tfrc)
Anatomy Link Frequency
plasma 3
coronary artery 1
Tfrc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tricyclic antidepressant 3 99.52 Very High Very High Very High
Pain 1 99.24 Very High Very High Very High
depression 15 99.00 Very High Very High Very High
fluoxetine 3 98.94 Very High Very High Very High
cytokine 70 98.60 Very High Very High Very High
Central nervous system 5 76.44 Quite High
Inflammation 5 58.40 Quite High
Angina 2 56.20 Quite High
Bile 5 53.76 Quite High
corticosteroid 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 1 99.76 Very High Very High Very High
Coronary Artery Disease 10 99.24 Very High Very High Very High
Depression 15 99.00 Very High Very High Very High
Hypersplenism 1 97.44 Very High Very High Very High
Targeted Disruption 10 95.52 Very High Very High Very High
Injury 30 91.56 High High
Disease 12 90.84 High High
Sickle Cell Anemia 8 90.52 High High
Abscess 10 78.00 Quite High
Hepatotoxicity 5 72.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum TfR levels did not change with infection or painful crisis but were markedly elevated in hypersplenism and fell following splenectomy in these subjects.
Neg (not) Regulation (change) of TfR associated with pain, hypersplenism and infection
1) Confidence 0.43 Published 1993 Journal Br. J. Haematol. Section Abstract Doc Link 8398834 Disease Relevance 1.28 Pain Relevance 0.10
But a majority of respondents in both the WW and TFR groups indicated no concern about performance of any of the activities.
Regulation (respondents) of TFR
2) Confidence 0.39 Published 2007 Journal J. Am. Coll. Surg. Section Body Doc Link 17765156 Disease Relevance 0.06 Pain Relevance 0
The purpose of this study was to investigate the plasma concentrations of interleukin (IL)-6, soluble IL-6 receptor (sIL-6R), sIL-2R and transferrin receptor (TfR) in patients with major depression in an acute phase of illness, in remission and during antidepressive treatment.
Spec (investigate) Regulation (concentrations) of transferrin receptor in plasma associated with depression
3) Confidence 0.17 Published 1995 Journal J Affect Disord Section Abstract Doc Link 8550956 Disease Relevance 0.27 Pain Relevance 0.22
Subchronic treatment with antidepressive drugs, such as fluoxetine or tricyclic antidepressants, did not significantly affect plasma IL-6, sIL-6R, sIL-2R or TfR.
Neg (not) Regulation (affect) of TfR in plasma associated with tricyclic antidepressant and fluoxetine
4) Confidence 0.17 Published 1995 Journal J Affect Disord Section Abstract Doc Link 8550956 Disease Relevance 0.30 Pain Relevance 0.33
The purpose of this study was to investigate the plasma concentrations of interleukin (IL)-6, soluble IL-6 receptor (sIL-6R), sIL-2R and transferrin receptor (TfR) in patients with major depression in an acute phase of illness, in remission and during antidepressive treatment.
Spec (investigate) Regulation (concentrations) of TfR in plasma associated with depression
5) Confidence 0.17 Published 1995 Journal J Affect Disord Section Abstract Doc Link 8550956 Disease Relevance 0.27 Pain Relevance 0.22
Use of this model in the current study is also of special interest as the down-regulation of TR?
Regulation (regulation) of TR
6) Confidence 0.11 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0.61 Pain Relevance 0.04
2 has been shown to have an inhibitory effect on the other TR isoforms (Koenig et al. 1989).
Regulation (effect) of TR
7) Confidence 0.11 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0.17 Pain Relevance 0.04
Likewise, an up-regulation of TR?
Regulation (regulation) of TR
8) Confidence 0.11 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0 Pain Relevance 0.15
Our current study has shown that transcription of T3-controlled TR genes is severely affected during APR; this might be more dependent on cytokines and the TH level than on the TH level alone.
Regulation (controlled) of TR associated with cytokine
9) Confidence 0.11 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0.13 Pain Relevance 0.23
1 and up-regulation of TR?
Regulation (regulation) of TR
10) Confidence 0.11 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0.60 Pain Relevance 0.04
Value of serum ferritin and soluble transferrin receptor for prediction of coronary artery disease and its clinical presentations.
Regulation (Value) of soluble transferrin receptor in coronary artery associated with coronary artery disease
11) Confidence 0.01 Published 2004 Journal Atherosclerosis Section Title Doc Link 15135258 Disease Relevance 0.74 Pain Relevance 0.11

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