INT59815

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Context Info
Confidence 0.67
First Reported 1993
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 1.12
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PLCB1) signal transduction (PLCB1) nucleus (PLCB1)
enzyme binding (PLCB1) cytoplasm (PLCB1) signal transducer activity (PLCB1)
Anatomy Link Frequency
uterine 2
cardiomyocytes 1
PLCB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 7 99.92 Very High Very High Very High
bradykinin 1 99.78 Very High Very High Very High
opioid receptor 5 97.08 Very High Very High Very High
Dismenorea 6 96.28 Very High Very High Very High
Enkephalin 2 89.96 High High
Opioid 2 89.12 High High
agonist 5 86.88 High High
Analgesic 1 25.00 Low Low
cytokine 14 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parasitemia 14 98.12 Very High Very High Very High
Dysmenorrhea 6 96.28 Very High Very High Very High
Bordatella Infection 1 93.16 High High
Glioma 1 82.24 Quite High
Neuroblastoma 2 81.88 Quite High
Ganglion Cysts 4 73.44 Quite High
Stress 2 71.84 Quite High
Loss Of Sense Of Smell 11 50.00 Quite Low
Death 5 45.84 Quite Low
Overactive Bladder 23 36.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Events that are not linked to receptors, such as mechanical loading (stretching) of cardiomyocytes, can also activate phospholipase C.
Positive_regulation (activate) of phospholipase C in cardiomyocytes
1) Confidence 0.67 Published 1993 Journal Cardioscience Section Abstract Doc Link 8400019 Disease Relevance 0 Pain Relevance 0.13
The high capacity for resynthesis of PIP2 maintains the pool of PIP2, even during maximal activation of phospholipase C.
Positive_regulation (activation) of phospholipase C
2) Confidence 0.67 Published 1993 Journal Cardioscience Section Abstract Doc Link 8400019 Disease Relevance 0 Pain Relevance 0.13
Accordingly, a stimulation of phospholipase C will release the actin-binding proteins profilin and gelsolin from phospholipids, which in turn liberates Ca2+ from F-actin.
Positive_regulation (stimulation) of phospholipase C
3) Confidence 0.67 Published 2007 Journal BMC Neuroscience Section Body Doc Link PMC1995455 Disease Relevance 0.14 Pain Relevance 0
Release of Ca2+ from intracellular stores could potentially occur by at least two pathways; classical activation of muscarinic receptors coupled to G proteins activating phospholipase C leading to production of diacylglycerol and IP3 which would cause release of Ca2+ from the IP3-sensitive store, or Ca2+-induced Ca2+ release (CICR) from the intracellular stores.


Positive_regulation (leading) of phospholipase C
4) Confidence 0.67 Published 2008 Journal American Journal of Physiology - Renal Physiology Section Body Doc Link PMC2640952 Disease Relevance 0 Pain Relevance 0.04
The phospholipase C specific inhibitor 1-[6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl]-1H -pyrrole-2,5-dione (U73122), which did not affect basal and forskolin-stimulated adenylyl cyclase activities, time- and dose-dependently blocked delta-opioid receptor-mediated inhibition of adenylyl cyclase activity, the EC50 (0.5 microM) of which was consistent with that for inhibition of bradykinin-dependent phospholipase C activation (EC50 = 1 microM).
Positive_regulation (activation) of phospholipase C associated with opioid receptor and bradykinin
5) Confidence 0.49 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9543254 Disease Relevance 0.25 Pain Relevance 0.19
However, by analyzing a GPI-PLC null mutant trypanosome it was shown that the GPI-PLC is not essential and is not necessary for antigenic variation, though it influences parasitemia in mice [164].
Neg (not) Positive_regulation (necessary) of PLC associated with parasitemia
6) Confidence 0.45 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2826769 Disease Relevance 0.17 Pain Relevance 0
Requirements for PLCbeta, protein kinase C (PKC), and calmodulin-dependent kinase II (CaMKII) in Galpha14QL-induced STAT3 activation were demonstrated by their respective inhibitors as well as by coexpression of their dominant-negative mutants.
Positive_regulation (Requirements) of PLCbeta associated with kinase c
7) Confidence 0.01 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15155836 Disease Relevance 0.09 Pain Relevance 0.27
These studies sought to determine which non-receptor protein tyrosine kinases are involved in the activation of phospholipase C1 in rat uterine tissue.
Positive_regulation (activation) of phospholipase C1 in uterine
8) Confidence 0.00 Published 2009 Journal Reprod Sci Section Abstract Doc Link 19208792 Disease Relevance 0.24 Pain Relevance 0.24
Activated phospholipase C1, produced in response to tyrosine phosphorylation, appears to play an important role during uterine contractions.
Positive_regulation (Activated) of phospholipase C1 in uterine associated with dismenorea
9) Confidence 0.00 Published 2009 Journal Reprod Sci Section Abstract Doc Link 19208792 Disease Relevance 0.22 Pain Relevance 0.22

General Comments

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