INT59816

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Context Info
Confidence 0.49
First Reported 1993
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.22
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PLCB1) signal transduction (PLCB1) nucleus (PLCB1)
enzyme binding (PLCB1) cytoplasm (PLCB1) signal transducer activity (PLCB1)
Anatomy Link Frequency
uterine 2
PLCB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 2 99.28 Very High Very High Very High
Dismenorea 3 96.68 Very High Very High Very High
Opioid 1 48.32 Quite Low
Disease Link Frequency Relevance Heat
Dysmenorrhea 3 96.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The other product of phospholipase C, 1,2-diacylglycerol, activates Ca(2+)-dependent protein kinase C and potentially controls a wide array of cellular functions such as ion transport, myofibrillar Ca2+ sensitivity, "cross-talk" between phospholipases C and D, gene expression, protein synthesis and hypertrophic cell growth.
Positive_regulation (activates) of Gene_expression (product) of phospholipase C associated with kinase c
1) Confidence 0.49 Published 1993 Journal Cardioscience Section Abstract Doc Link 8400019 Disease Relevance 0 Pain Relevance 0.09
Activated phospholipase C1, produced in response to tyrosine phosphorylation, appears to play an important role during uterine contractions.
Positive_regulation (Activated) of Gene_expression (produced) of phospholipase C1 in uterine associated with dismenorea
2) Confidence 0.00 Published 2009 Journal Reprod Sci Section Abstract Doc Link 19208792 Disease Relevance 0.22 Pain Relevance 0.22

General Comments

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