INT59817

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Context Info
Confidence 0.75
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.73
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PLCB1) signal transduction (PLCB1) nucleus (PLCB1)
enzyme binding (PLCB1) cytoplasm (PLCB1) signal transducer activity (PLCB1)
Anatomy Link Frequency
plasma 1
uterine 1
PLCB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Analgesic 1 100.00 Very High Very High Very High
Enkephalin 1 100.00 Very High Very High Very High
Kinase C 2 98.04 Very High Very High Very High
Dismenorea 3 96.68 Very High Very High Very High
opioid receptor 3 80.80 Quite High
bradykinin 1 75.20 Quite High
Opioid 1 48.32 Quite Low
cytokine 14 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dysmenorrhea 3 96.68 Very High Very High Very High
Neuroblastoma 2 93.00 High High
Glioma 1 92.36 High High
Death 4 88.56 High High
Stress 2 83.52 Quite High
Trypanosomiasis 31 80.80 Quite High
Infection 53 5.00 Very Low Very Low Very Low
Disease 26 5.00 Very Low Very Low Very Low
African Trypanosomiasis 22 5.00 Very Low Very Low Very Low
Parasitemia 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The other product of phospholipase C, 1,2-diacylglycerol, activates Ca(2+)-dependent protein kinase C and potentially controls a wide array of cellular functions such as ion transport, myofibrillar Ca2+ sensitivity, "cross-talk" between phospholipases C and D, gene expression, protein synthesis and hypertrophic cell growth.
Gene_expression (product) of phospholipase C associated with kinase c
1) Confidence 0.75 Published 1993 Journal Cardioscience Section Abstract Doc Link 8400019 Disease Relevance 0 Pain Relevance 0.08
The GPI-PLC expressed by one parasite only targets its own plasma membrane and as such is unable to release the VSG of another parasite [155].
Gene_expression (expressed) of PLC in plasma
2) Confidence 0.75 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2826769 Disease Relevance 0.25 Pain Relevance 0
Suppression of phospholipase C blocks Gi-mediated inhibition of adenylyl cyclase activity.
Gene_expression (Suppression) of phospholipase C associated with analgesic
3) Confidence 0.65 Published 1998 Journal Eur. J. Pharmacol. Section Title Doc Link 9543254 Disease Relevance 0.25 Pain Relevance 0.34
Activated phospholipase C1, produced in response to tyrosine phosphorylation, appears to play an important role during uterine contractions.
Gene_expression (produced) of phospholipase C1 in uterine associated with dismenorea
4) Confidence 0.01 Published 2009 Journal Reprod Sci Section Abstract Doc Link 19208792 Disease Relevance 0.22 Pain Relevance 0.22

General Comments

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