INT59818

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Context Info
Confidence 0.57
First Reported 1993
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 9
Disease Relevance 2.24
Pain Relevance 2.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PLCB1) signal transduction (PLCB1) nucleus (PLCB1)
enzyme binding (PLCB1) cytoplasm (PLCB1) signal transducer activity (PLCB1)
Anatomy Link Frequency
cardiomyocytes 1
NG108-15 1
SK-N-SH 1
PLCB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 3 100.00 Very High Very High Very High
Analgesic 3 100.00 Very High Very High Very High
substance P 10 99.08 Very High Very High Very High
opioid receptor 9 93.48 High High
Inflammation 7 92.44 High High
Spontaneous pain 1 90.32 High High
qutenza 3 89.32 High High
antagonist 31 88.32 High High
Hyperalgesia 5 86.40 High High
dorsal root ganglion 4 82.24 Quite High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 16 98.32 Very High Very High Very High
Neuroblastoma 6 97.56 Very High Very High Very High
Glioma 3 96.92 Very High Very High Very High
Hypertension 43 94.64 High High
INFLAMMATION 7 92.44 High High
Pain 6 90.32 High High
Hyperalgesia 5 86.40 High High
Ganglion Cysts 4 82.24 Quite High
Overactive Bladder 69 79.16 Quite High
Adhesions 4 77.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cultured cardiomyocytes, incubated in sera containing the fatty acids 18:2n-6 or 20:5n-3, but not 18:0 and 18:1n-9, show a decrease in the phospholipase C responses mediated by alpha 1-adrenoceptors.
Negative_regulation (decrease) of phospholipase C in cardiomyocytes
1) Confidence 0.57 Published 1993 Journal Cardioscience Section Abstract Doc Link 8400019 Disease Relevance 0 Pain Relevance 0.04
U73122 treatment also blocked functional responses of m4 muscarinic receptor and alpha2-adrenoceptor in NG108-15 cells and three opioid receptors (mu, delta and opioid receptor-like receptor (ORL1)) in human neuroblastoma SK-N-SH cells. 1-[6-((17Beta-3-Methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl]-2, 5-pyrrolidinedione (U73343), an inactive analog of U73122, did not show any effect, which suggests that the blockade by U73122 of Gi-coupled receptor-mediated signaling is probably mediated through inhibition of phospholipase C, although a possible direct modification of G proteins can not be excluded.
Negative_regulation (inhibition) of phospholipase C in SK-N-SH associated with neuroblastoma and opioid receptor
2) Confidence 0.57 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9543254 Disease Relevance 0.21 Pain Relevance 0.17
The potential effect of inhibition of phospholipase C on the response of Gi-coupled receptors was investigated in neuroblastoma x glioma hybrid (NG108-15) cells.
Negative_regulation (inhibition) of phospholipase C in NG108-15 associated with neuroblastoma and glioma
3) Confidence 0.57 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9543254 Disease Relevance 0.19 Pain Relevance 0.07
Sar-SP-induced potentiation of TRPV1 was blocked by inhibition of G-protein, PLCbeta (phospholipase C-beta), or PKC but not by inhibition of PKA (protein kinase A).
Negative_regulation (inhibition) of PLCbeta associated with substance p
4) Confidence 0.57 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17978048 Disease Relevance 0.91 Pain Relevance 1.54
adenylate cyclase activity and inhibition of phospholipase-C
Negative_regulation (inhibition) of phospholipase-C
5) Confidence 0.57 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC555773 Disease Relevance 0.36 Pain Relevance 0
U-73122, an inhibitor of phospholipase C (21), consistently reduced the carbachol responses without affecting basal Ca2+.
Negative_regulation (inhibitor) of phospholipase C
6) Confidence 0.57 Published 2008 Journal American Journal of Physiology - Renal Physiology Section Body Doc Link PMC2640952 Disease Relevance 0 Pain Relevance 0.04
Suppression of phospholipase C blocks Gi-mediated inhibition of adenylyl cyclase activity.
Negative_regulation (Suppression) of phospholipase C associated with analgesic
7) Confidence 0.42 Published 1998 Journal Eur. J. Pharmacol. Section Title Doc Link 9543254 Disease Relevance 0.25 Pain Relevance 0.34
The effect of inhibition of phospholipase C was tested using U-73122 (2.5 ?
Negative_regulation (inhibition) of phospholipase C
8) Confidence 0.42 Published 2008 Journal American Journal of Physiology - Renal Physiology Section Body Doc Link PMC2640952 Disease Relevance 0 Pain Relevance 0
The phospholipase C inhibitor, U-73122 (2.5 ?
Negative_regulation (inhibitor) of phospholipase C
9) Confidence 0.41 Published 2008 Journal American Journal of Physiology - Renal Physiology Section Abstract Doc Link PMC2640952 Disease Relevance 0.32 Pain Relevance 0.08

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