INT59837

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Context Info
Confidence 0.03
First Reported 1993
Last Reported 2010
Negated 5
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 1.37
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Upf1) helicase activity (Upf1) cell cycle (Upf1)
DNA binding (Upf1) cytoplasm (Upf1)
Anatomy Link Frequency
PVH 1
salivary gland 1
hippocampus 1
Upf1 (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 3 97.50 Very High Very High Very High
Hippocampus 49 95.96 Very High Very High Very High
Endep 68 95.70 Very High Very High Very High
fluoxetine 108 94.80 High High
cytokine 25 79.80 Quite High
Serotonin 60 50.00 Quite Low
Central nervous system 22 48.64 Quite Low
agonist 13 42.32 Quite Low
antidepressant 12 31.48 Quite Low
antagonist 4 21.40 Low Low
Disease Link Frequency Relevance Heat
Stress 9 98.82 Very High Very High Very High
Injury 50 93.56 High High
Targeted Disruption 56 89.28 High High
Influenza Virus Infection 5 76.68 Quite High
Meningitis 1 75.00 Quite High
Hyperphagia 4 61.00 Quite High
Obesity 6 54.56 Quite High
Sprains And Strains 41 52.60 Quite High
Wound Healing 27 38.68 Quite Low
Syndrome 70 28.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite their diverse genomic locations, these transcripts were controlled by the segregating pattern of the C57BL/6 and DBA/2J alleles corresponding to chromosome 12 locus (Fig. 1A).
Regulation (controlled) of transcripts
1) Confidence 0.03 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.63 Pain Relevance 0
Furthermore, our data indicate that chronic treatment leads to reciprocal changes in transcripts that are either unedited or fully edited at the A and B or C and D sites, with no change in transcripts edited at only one or the other site.
Neg (no) Regulation (change) of transcripts
2) Confidence 0.01 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2879535 Disease Relevance 0.06 Pain Relevance 0.25
Two-way ANOVA analysis (P < 0.0001) and Bonferroni post-tests for pair-wise comparisons indicates that fluoxetine (striatum and hippocampus) and amitriptyline (hippocampus) treatment lead to a decrease in the proportion of transcripts unedited at both the A and B sites (AA***), an increase in the proportion of transcripts edited at both the A and B sites (GG***), and no change in transcripts edited at either the A or B site (AG*** and GA***).
Regulation (change) of transcripts in hippocampus associated with hippocampus, endep and fluoxetine
3) Confidence 0.01 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2879535 Disease Relevance 0 Pain Relevance 0.81
Two-way ANOVA analysis (P < 0.0001) and Bonferroni post-tests for pair-wise comparisons indicates that lithium treatment leads to a decrease in the proportion of transcripts unedited at both the C and D sites (***AA), an increase in the proportion of transcripts edited at both the C and D sites (***GG), and no change in transcripts edited at either the C or D site (***AG and ***GA).
Neg (no) Regulation (change) of transcripts
4) Confidence 0.01 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2879535 Disease Relevance 0 Pain Relevance 0
Two-way ANOVA analysis (P < 0.0001) and Bonferroni post-tests for pair-wise comparisons indicates that SB206553 treatment leads to a decrease in the proportion of transcripts unedited at both the A and B sites (AA***), an increase in the proportion of transcripts edited at both the A and B sites (GG***), and no change in transcripts edited at either the A or B site (AG*** and GA***).
Neg (no) Regulation (change) of transcripts
5) Confidence 0.01 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2879535 Disease Relevance 0 Pain Relevance 0.04
Further support for this idea is obtained by correlating fold-increase or -decrease of affected transcripts.
Regulation (affected) of transcripts
6) Confidence 0.01 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.05 Pain Relevance 0
transcripts were not significantly changed by tick feeding or intradermal injection of salivary gland proteins, suggesting a superimposed Th2 response.
Neg (not) Regulation (changed) of transcripts in salivary gland
7) Confidence 0.01 Published 2009 Journal Parasit Vectors Section Abstract Doc Link PMC2764639 Disease Relevance 0.31 Pain Relevance 0.10
Tetrodotoxin, administered to the PVH via osmotic minipump, blocked the stress-induced rise in CRF and AVP mRNAs, but had no significant effect on basal levels of these transcripts.
Neg (no) Regulation (effect) of transcripts in PVH associated with stress and tetrodotoxin
8) Confidence 0.00 Published 1993 Journal J. Neuroendocrinol. Section Abstract Doc Link 8401558 Disease Relevance 0.31 Pain Relevance 0.25

General Comments

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