INT59842

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Context Info
Confidence 0.98
First Reported 1993
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 2.49
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Maoa) oxidoreductase activity (Maoa)
Anatomy Link Frequency
platelet 1
Maoa (Mus musculus)
Pain Link Frequency Relevance Heat
monoamine 9 100.00 Very High Very High Very High
fluoxetine 1 92.80 High High
antagonist 2 90.16 High High
sSRI 2 10.24 Low Low
addiction 6 5.00 Very Low Very Low Very Low
Serotonin 3 5.00 Very Low Very Low Very Low
Nicotine 2 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
gABA 1 5.00 Very Low Very Low Very Low
antidepressant 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 171 98.20 Very High Very High Very High
Atherosclerosis 3 19.04 Low Low
Diabetes Mellitus 2 8.36 Low Low
Hypertension 2 7.12 Low Low
Obesity 2 5.60 Low Low
Lung Cancer 3 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low
Cardiovascular Disorder Under Development 2 5.00 Very Low Very Low Very Low
Coronary Artery Disease 2 5.00 Very Low Very Low Very Low
Disorder Of Lipid Metabolism 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The fact that platelet 5-HT was more degraded into 5-HIAA suggested that the enzyme responsible for this degradation, MAO, was either more active or more abundant in FS.
Protein_catabolism (degradation) of MAO in platelet associated with nicotine addiction
1) Confidence 0.98 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 2.49 Pain Relevance 0.05
The monoamine oxidase inhibitor tranylcypromine effectively blocked degradation of injected 5-hydroxytryptamine and accumulation of 5-hydroxyindoleacetic acid.
Protein_catabolism (degradation) of monoamine oxidase associated with monoamine
2) Confidence 0.65 Published 1993 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8402383 Disease Relevance 0 Pain Relevance 0.27

General Comments

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