INT59846

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Context Info
Confidence 0.54
First Reported 1993
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.28
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CLPP) mitochondrion (CLPP)
Anatomy Link Frequency
mononuclear cells 1
CLPP (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 10 99.52 Very High Very High Very High
cocaine 4 99.06 Very High Very High Very High
narcan 1 95.72 Very High Very High Very High
Enkephalin 2 92.92 High High
Dynorphin 1 79.72 Quite High
orphanin 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Leukemia 2 97.76 Very High Very High Very High
Neuroblastoma 1 52.48 Quite High
Lung Cancer 1 51.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When treated with concanavalin A and cocaine, peripheral blood mononuclear cells showed an enhanced activity (+110 per cent) of the membrane neutral endopeptidase, which was not related to the expression of the common acute lymphoblastic leukemia antigen at the cell surface, although both molecules have the identical amino acid sequence.
Positive_regulation (enhanced) of endopeptidase in mononuclear cells associated with leukemia and cocaine
1) Confidence 0.54 Published 1993 Journal Cell Biochem. Funct. Section Abstract Doc Link 8403235 Disease Relevance 0.17 Pain Relevance 0.66
Taken together, the findings suggest that a metallosensitive endopeptidase, the activity of which is increased by chronic morphine treatment of the cells, is responsible for the biotransformation of NOFQ with fragments N1-9 and N1-13 being the major products.
Positive_regulation (increased) of endopeptidase associated with morphine
2) Confidence 0.05 Published 1999 Journal Brain Res. Section Abstract Doc Link 10082806 Disease Relevance 0.10 Pain Relevance 0.65

General Comments

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