INT5987

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Context Info
Confidence 0.49
First Reported 1984
Last Reported 2009
Negated 0
Speculated 4
Reported most in Abstract
Documents 11
Total Number 16
Disease Relevance 2.81
Pain Relevance 12.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprl1) signal transducer activity (Oprl1)
Anatomy Link Frequency
spinal 6
ventromedial hypothalamic nucleus 2
central nervous system 2
Oprl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Buprenorphine 216 100.00 Very High Very High Very High
opioid receptor 43 100.00 Very High Very High Very High
opiate 25 100.00 Very High Very High Very High
Dynorphin 5 100.00 Very High Very High Very High
Kappa opioid receptor 4 100.00 Very High Very High Very High
Enkephalin 11 99.98 Very High Very High Very High
Cholecystokinin 13 99.96 Very High Very High Very High
Antinociceptive 6 99.32 Very High Very High Very High
Analgesic 87 99.18 Very High Very High Very High
orphanin 35 98.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 13 100.00 Very High Very High Very High
Natriuresis 6 100.00 Very High Very High Very High
Appetite Loss 4 99.44 Very High Very High Very High
Spinal Injuries 2 98.76 Very High Very High Very High
Pain 245 98.18 Very High Very High Very High
Bordatella Infection 3 98.00 Very High Very High Very High
Neuroblastoma 1 96.36 Very High Very High Very High
Nociception 10 90.00 High High
Hyperalgesia 13 82.76 Quite High
Syndrome 16 81.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that stimulation of ORL1 receptor accelerates the colonic contraction and transit independently from opioid receptors.
Positive_regulation (accelerates) of Positive_regulation (stimulation) of ORL1 receptor associated with opioid receptor
1) Confidence 0.49 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9726656 Disease Relevance 0 Pain Relevance 0.83
Such effects of NOC were seemingly mediated by the activation of specific ORL1 receptors, as a well-known nociceptin antagonist, N(Phe1)nociceptin (1-13)NH2, was able to completely revert NOC inhibition of capsaicin-stimulated CGRP release.
Positive_regulation (mediated) of Positive_regulation (activation) of ORL1 associated with qutenza, antagonist and orphanin
2) Confidence 0.49 Published 2007 Journal Cephalalgia Section Abstract Doc Link 17640294 Disease Relevance 0.09 Pain Relevance 0.57
These findings suggested that r/m HK-1 might play an important role in pain modulation at supraspinal level in mice and these effects were first elicited through the activation of NK(1) receptor, subsequently, whether activation of the classical opioid receptor or the ORL1 receptor depending on the dose of i.c.v. administration of r/m HK-1.
Spec (whether) Positive_regulation (activation) of Spec (whether) Positive_regulation (activation) of ORL1 associated with pain and opioid receptor
3) Confidence 0.49 Published 2005 Journal Brain Res. Section Abstract Doc Link 16102736 Disease Relevance 0.49 Pain Relevance 0.61
Since dynorphin, which has been implicated as an injury factor after spinal trauma, shows similar localized increases after spinal injury, the present data are consistent with the hypothesis that up-regulation of the kappa-receptor after injury may contribute to the subsequent secondary injury process.
Spec (may) Positive_regulation (contribute) of Positive_regulation (regulation) of kappa-receptor in spinal associated with dynorphin, injury and spinal injuries
4) Confidence 0.44 Published 1986 Journal Ann. Neurol. Section Abstract Doc Link 3013077 Disease Relevance 0.88 Pain Relevance 0.90
The substitution of tyrosine for phenylalanine at position three resulted in a large increase in opiate receptor affinity which may be related to the known requirement for a phenolic hydroxyl moiety in the rigid opiate and enkephalin systems.
Positive_regulation (requirement) of Positive_regulation (increase) of opiate receptor associated with enkephalin and opiate
5) Confidence 0.39 Published 1985 Journal Peptides Section Abstract Doc Link 2864680 Disease Relevance 0 Pain Relevance 0.75
Activation of mu or ORL1 receptors in these cells in turn activates extracellular signal-regulated protein kinases (ERKs), ERK1 and ERK2.
Positive_regulation (activates) of Positive_regulation (Activation) of ORL1
6) Confidence 0.35 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12399106 Disease Relevance 0.16 Pain Relevance 1.27
Activation of the mu-opiate receptor, however, may facilitate cholecystokinin messenger RNA expression in the bed nucleus of the stria terminalis and preprotachykinin messenger RNA expression in the ventromedial hypothalamic nucleus.
Spec (may) Positive_regulation (facilitate) of Positive_regulation (Activation) of mu-opiate receptor in ventromedial hypothalamic nucleus associated with opiate and cholecystokinin
7) Confidence 0.29 Published 1997 Journal Neuroscience Section Abstract Doc Link 9284350 Disease Relevance 0 Pain Relevance 1.24
ERK1/ERK2 activation is inhibited by pertussis toxin, the MEK inhibitor PD 98059 and by transient expression of alpha-transducin, indicating that ORL1 up-regulation of these kinases occurs as a consequence of the release of the G-protein betagamma complex following the activation of pertussis-toxin sensitive Galphai-family G-proteins.
Positive_regulation (occurs) of Positive_regulation (regulation) of ORL1 associated with bordatella infection
8) Confidence 0.22 Published 1998 Journal Neuroreport Section Abstract Doc Link 9760105 Disease Relevance 0.35 Pain Relevance 0.04
Taken together, it is suggested that the inhibition by met-Enk of I(ATP) is caused by activation of opiate receptor, which eventually results in phosphorylation of ATP receptor, mediated by modulation of G protein coupling and intracellular signal transduction.
Positive_regulation (mediated) of Positive_regulation (activation) of opiate receptor associated with opiate
9) Confidence 0.20 Published 2001 Journal Sheng Li Xue Bao Section Abstract Doc Link 12589405 Disease Relevance 0 Pain Relevance 0.13
[Activation of delta-opiate receptor simultaneously stimulates ACTH beta-endorphin and prolactin release].
Positive_regulation (stimulates) of Positive_regulation (Activation) of delta-opiate receptor associated with enkephalin and opiate
10) Confidence 0.17 Published 1992 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Title Doc Link 1319850 Disease Relevance 0 Pain Relevance 0.58
In conclusion, CNP-stimulated pancreatic flow through the activation of the natriuretic peptide receptor C and the vago-vagal reflex but it increased protein output only by natriuretic peptide receptor C activation and chloride excretion by vago-vagal reflexes.
Positive_regulation (increased) of Positive_regulation (activation) of peptide receptor associated with natriuresis
11) Confidence 0.15 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17900562 Disease Relevance 0.34 Pain Relevance 0.18
In the rat, activation of both the dynorphin-kappa opioid receptor and the beta-endorphin-epsilon opioid receptor appear to enhance feeding, most probably acting in different areas of the central nervous system.
Spec (appear) Positive_regulation (enhance) of Positive_regulation (activation) of dynorphin-kappa opioid receptor in central nervous system associated with dynorphin, kappa opioid receptor, central nervous system and opioid receptor
12) Confidence 0.15 Published 1984 Journal Appetite Section Abstract Doc Link 6148913 Disease Relevance 0.19 Pain Relevance 0.59
The functional roles of the EL2 loop and the conserved N-terminal tetrapeptide opioid 'message' binding site are discussed in the context of the different structural requirements of the ORL1 and kappa-opioid receptors for activation.
Positive_regulation (requirements) of Positive_regulation (requirements) of ORL1 associated with kappa opioid receptor and opioid
13) Confidence 0.10 Published 1998 Journal Protein Eng. Section Abstract Doc Link 9930666 Disease Relevance 0 Pain Relevance 0.48
The current results implicate opioid receptors as critical downstream mediators of the potent effects of AgRP to increase food intake but indicate that either micro - or kappa-receptor activation is sufficient for AgRP's effect.
Positive_regulation (sufficient) of Positive_regulation (activation) of kappa-receptor associated with opioid receptor
14) Confidence 0.07 Published 2002 Journal Endocrinology Section Abstract Doc Link 12399421 Disease Relevance 0 Pain Relevance 0.49
Buprenorphine exhibits a lower (50% to 70%) degree of agonism at the nociceptin receptor compared with the endogenous ligand nociceptin, which leads to antinociception via opioid receptor-like receptor-1 (ORL-1)-mediated mechanisms, particularly at high doses.32–35 Following systemic administration of buprenorphine, this analgesic effect can be countered by simultaneous activation of supraspinal ORL-1 receptors.36 Conversely, sole activation of spinal ORL-1 receptors by buprenorphine may lead to an important antinociceptive effect, which might explain the strong analgesic action observed after intrathecal administration of buprenorphine;37–40 however, some evidence suggests a supraspinal site of action after neuraxial administration.41,42 Overall, the clinical result following administration of buprenorphine, by whichever route, is dose-related analgesia and, therefore, the precise involvement of the ORL-1 receptor remains unclear.18


Positive_regulation (lead) of Positive_regulation (activation) of ORL-1 in spinal associated with analgesic, opioid receptor, antinociceptive, analgesia, buprenorphine, antinociception, orphanin and intrathecal
15) Confidence 0.03 Published 2009 Journal Journal of pain research Section Body Doc Link PMC3004620 Disease Relevance 0.16 Pain Relevance 1.97
Buprenorphine exhibits a lower (50% to 70%) degree of agonism at the nociceptin receptor compared with the endogenous ligand nociceptin, which leads to antinociception via opioid receptor-like receptor-1 (ORL-1)-mediated mechanisms, particularly at high doses.32–35 Following systemic administration of buprenorphine, this analgesic effect can be countered by simultaneous activation of supraspinal ORL-1 receptors.36 Conversely, sole activation of spinal ORL-1 receptors by buprenorphine may lead to an important antinociceptive effect, which might explain the strong analgesic action observed after intrathecal administration of buprenorphine;37–40 however, some evidence suggests a supraspinal site of action after neuraxial administration.41,42 Overall, the clinical result following administration of buprenorphine, by whichever route, is dose-related analgesia and, therefore, the precise involvement of the ORL-1 receptor remains unclear.18


Positive_regulation (lead) of Positive_regulation (activation) of ORL-1 in spinal associated with analgesic, opioid receptor, antinociceptive, analgesia, buprenorphine, antinociception, orphanin and intrathecal
16) Confidence 0.03 Published 2009 Journal Journal of pain research Section Body Doc Link PMC3004620 Disease Relevance 0.16 Pain Relevance 1.93

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