INT59871

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Context Info
Confidence 0.22
First Reported 1993
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.88
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (FPR1) signal transduction (FPR1) plasma membrane (FPR1)
signal transducer activity (FPR1)
Anatomy Link Frequency
PMNs 2
FPR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 4 98.22 Very High Very High Very High
cINOD 2 90.28 High High
agonist 3 23.76 Low Low
Angina 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coagulation Disorder 1 99.28 Very High Very High Very High
INFLAMMATION 5 89.72 High High
Obstructive Sleep Apnea 73 88.28 High High
Hypoxia 12 80.08 Quite High
Metabolic Disorder 1 52.20 Quite High
Obesity 8 49.48 Quite Low
Nicotine Addiction 5 33.00 Quite Low
Apnoea 2 22.40 Low Low
Sleep Disorders 11 5.00 Very Low Very Low Very Low
Stress 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tolfenamic acid inhibited LTB4 production in PMNs as well as FMLP- and LTB4-induced PMN migration (IC50 values 23 +/- 3, 39 +/- 11, and 68 +/- 13 microM, respectively), whereas flunixin inhibited these cell functions only with the highest concentration tested (100 microM).
Negative_regulation (inhibited) of Gene_expression (production) of FMLP in PMNs
1) Confidence 0.22 Published 1993 Journal Inflammation Section Abstract Doc Link 8406686 Disease Relevance 0.24 Pain Relevance 0.09
Catecholamines in vitro, especially epinephrine at physiologic levels revealed concentration dependent inhibition of fMLP-induced degranulation and superoxide radical production by human PMNs [28-30]; with a capability of suppressive monocytic activity as well [31,32].
Negative_regulation (inhibition) of Gene_expression (production) of fMLP associated with catecholamine
2) Confidence 0.03 Published 2008 Journal J Negat Results Biomed Section Body Doc Link PMC2607253 Disease Relevance 0.63 Pain Relevance 0.14

General Comments

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