INT59878

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Context Info
Confidence 0.43
First Reported 1993
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.15
Pain Relevance 2.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcg) plasma membrane (Prkcg) nucleus (Prkcg)
intracellular (Prkcg) response to stress (Prkcg) cytoplasm (Prkcg)
Anatomy Link Frequency
spinal cord 2
spinal cord dorsal horn 2
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 16 100.00 Very High Very High Very High
Spinal cord 21 99.68 Very High Very High Very High
Dorsal horn 2 99.20 Very High Very High Very High
Sciatic nerve 7 97.84 Very High Very High Very High
allodynia 2 96.72 Very High Very High Very High
Calcitonin gene-related peptide 103 96.00 Very High Very High Very High
intrathecal 2 95.72 Very High Very High Very High
Spontaneous pain 3 94.72 High High
antagonist 22 94.32 High High
Thermal hyperalgesia 3 93.68 High High
Disease Link Frequency Relevance Heat
Injury 10 97.96 Very High Very High Very High
Nociception 7 97.80 Very High Very High Very High
Nervous System Injury 11 96.80 Very High Very High Very High
Neuropathic Pain 8 96.72 Very High Very High Very High
Pain 51 94.72 High High
Hyperalgesia 5 93.68 High High
Diabetic Nephropathy 3 75.00 Quite High
Frailty 1 75.00 Quite High
Shock 2 62.76 Quite High
Abnormal Reflex 1 52.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar correlations were observed between decreases in levels of membrane-bound PKC in the spinal cord dorsal horn and the attenuation of nociceptive behaviors in CCI rats after three daily intrathecal treatments with GM1 ganglioside.
Negative_regulation (decreases) of Transcription (levels) of PKC in spinal cord dorsal horn associated with nociception, kinase c, nervous system injury, dorsal horn, intrathecal and spinal cord
1) Confidence 0.43 Published 1993 Journal J. Neurophysiol. Section Abstract Doc Link 8410149 Disease Relevance 1.12 Pain Relevance 1.27
In contrast, co-administration of a PKC inhibitor (GF109203x, 100 ?
Negative_regulation (inhibitor) of Transcription (administration) of PKC
2) Confidence 0.26 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829526 Disease Relevance 0.22 Pain Relevance 0.54
The addition of a PKC inhibitor, chelerythrine (6 ?
Negative_regulation (inhibitor) of Transcription (addition) of PKC
3) Confidence 0.09 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.06 Pain Relevance 0.35
Real time RT-PCR was employed to determine the relative mRNA levels of NMDAR subunits, ppD and PKCgamma in the dorsal spinal cord 1, 14 and 28 days after injury.
Spec (determine) Negative_regulation (determine) of Spec (determine) Transcription (levels) of PKCgamma in spinal cord associated with injury and spinal cord
4) Confidence 0.04 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18835424 Disease Relevance 0.76 Pain Relevance 0.68

General Comments

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