INT59879

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Context Info
Confidence 0.69
First Reported 1993
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 2.29
Pain Relevance 5.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcg) plasma membrane (Prkcg) nucleus (Prkcg)
intracellular (Prkcg) response to stress (Prkcg) cytoplasm (Prkcg)
Anatomy Link Frequency
spinal cord 1
LGN 1
spinal cord dorsal horn 1
vas deferens 1
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 179 100.00 Very High Very High Very High
Spinal cord 23 99.68 Very High Very High Very High
Morphine 6 99.44 Very High Very High Very High
Dorsal horn 2 99.20 Very High Very High Very High
Sciatic nerve 7 97.32 Very High Very High Very High
intrathecal 2 95.72 Very High Very High Very High
allodynia 2 95.60 Very High Very High Very High
Calcitonin gene-related peptide 103 95.20 Very High Very High Very High
gABA 4 94.92 High High
antagonist 22 94.32 High High
Disease Link Frequency Relevance Heat
Injury 10 97.96 Very High Very High Very High
Nociception 7 97.80 Very High Very High Very High
Nervous System Injury 11 96.80 Very High Very High Very High
Neuropathic Pain 8 95.60 Very High Very High Very High
Pain 52 94.20 High High
Hyperalgesia 5 93.16 High High
Shock 4 83.00 Quite High
Diabetic Nephropathy 3 75.00 Quite High
Frailty 3 75.00 Quite High
Hepatocellular Cancer 2 59.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar correlations were observed between decreases in levels of membrane-bound PKC in the spinal cord dorsal horn and the attenuation of nociceptive behaviors in CCI rats after three daily intrathecal treatments with GM1 ganglioside.
Transcription (levels) of PKC in spinal cord dorsal horn associated with nociception, kinase c, nervous system injury, dorsal horn, intrathecal and spinal cord
1) Confidence 0.69 Published 1993 Journal J. Neurophysiol. Section Abstract Doc Link 8410149 Disease Relevance 1.11 Pain Relevance 1.26
Although RT-PCR experiments detected mRNA for some Ca2+-dependent/DAG-activated and Ca2+-independent/DAG-activated PKC isoforms in epididymal vas deferens, the PKC activators, phorbol 12, 13-dibutyrate (100 microM) or phorbol 12-myristate 13-acetate (100 microM) failed to activate the tissues in calcium-free medium but enhanced subsequent contractions to NA.
Transcription (detected) of PKC in vas deferens associated with kinase c and noradrenaline
2) Confidence 0.68 Published 1999 Journal Life Sci. Section Abstract Doc Link 10416820 Disease Relevance 0 Pain Relevance 0.71
The summarized data shown in Fig. 1B indicate that there was a significant (P < 0.05) decrease in the amounts of mRNA encoding PKC?
Transcription (encoding) of PKC associated with kinase c
3) Confidence 0.67 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0.25
The summarized data shown in Fig. 1B indicate that there was a significant (P < 0.05) decrease in the amounts of mRNA encoding PKC?
Transcription (amounts) of PKC associated with kinase c
4) Confidence 0.67 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0.25
In contrast, co-administration of a PKC inhibitor (GF109203x, 100 ?
Transcription (administration) of PKC
5) Confidence 0.42 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829526 Disease Relevance 0.22 Pain Relevance 0.54
Additionally, acute as well as chronic intraperitoneal morphine administration changed the abundance of PKC gamma, gamma1 subunit of GABAA and hsp70 genes.
Transcription (abundance) of PKC gamma associated with kinase c and morphine
6) Confidence 0.28 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15379885 Disease Relevance 0.08 Pain Relevance 0.64
The addition of a PKC inhibitor, chelerythrine (6 ?
Transcription (addition) of PKC
7) Confidence 0.15 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.06 Pain Relevance 0.35
In particular, the SRE element is an important region of the PKC-induced transcription of the c-fos gene, mediated by the activation of the ERK signaling cascade.
Transcription (transcription) of PKC associated with kinase c
8) Confidence 0.09 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.06 Pain Relevance 0.33
Real time RT-PCR was employed to determine the relative mRNA levels of NMDAR subunits, ppD and PKCgamma in the dorsal spinal cord 1, 14 and 28 days after injury.
Spec (determine) Transcription (levels) of PKCgamma in spinal cord associated with injury and spinal cord
9) Confidence 0.06 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18835424 Disease Relevance 0.75 Pain Relevance 0.68
Double-label ISH revealed that MARCKS mRNA was coexpressed with mRNA of GAP-43, another PKC substrate, in neurons of both the LGN and area 17.
Transcription (coexpressed) of PKC in LGN associated with kinase c
10) Confidence 0.03 Published 2002 Journal Vis. Neurosci. Section Abstract Doc Link 12507329 Disease Relevance 0 Pain Relevance 0.29

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