INT5988

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Context Info
Confidence 0.81
First Reported 1981
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 74
Total Number 76
Disease Relevance 17.52
Pain Relevance 24.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Dbi) transport (Dbi) mitochondrion (Dbi)
extracellular space (Dbi) plasma membrane (Dbi) nucleus (Dbi)
Anatomy Link Frequency
brain 7
pituitary 5
Leydig cells 2
striatum 2
NAcb 2
Dbi (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 41 100.00 Very High Very High Very High
antinociception 18 99.96 Very High Very High Very High
Dynorphin 23 99.88 Very High Very High Very High
alcohol 56 99.76 Very High Very High Very High
Nucleus accumbens 48 99.68 Very High Very High Very High
Central grey 9 99.68 Very High Very High Very High
agonist 62 99.48 Very High Very High Very High
Neuropeptide 18 99.32 Very High Very High Very High
cytokine 115 99.04 Very High Very High Very High
opiate 12 98.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Toxicity 33 100.00 Very High Very High Very High
Urological Neuroanatomy 28 99.68 Very High Very High Very High
Nociception 22 99.52 Very High Very High Very High
Stress 20 99.50 Very High Very High Very High
Thyroid Neoplasm 2 99.48 Very High Very High Very High
Anxiety Disorder 14 99.12 Very High Very High Very High
Arthritis 64 98.76 Very High Very High Very High
Infection 173 98.32 Very High Very High Very High
Volume Depletion And Dehydration 6 97.56 Very High Very High Very High
Obesity 9 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subcellular location and neuronal release of diazepam binding inhibitor.
Localization (release) of diazepam binding inhibitor in neuronal associated with neuropeptide
1) Confidence 0.81 Published 1987 Journal J. Neurochem. Section Title Doc Link 3819722 Disease Relevance 0 Pain Relevance 0.38
We recently suggested that diazepam binding inhibitor (DBI) was released in the brain after stimulation by an aversive taste and might be involved in the aversive sensations of taste.
Localization (released) of diazepam binding inhibitor in brain
2) Confidence 0.80 Published 2002 Journal J. Nutr. Sci. Vitaminol. Section Abstract Doc Link 12171440 Disease Relevance 0.18 Pain Relevance 0.09
We recently suggested that diazepam binding inhibitor (DBI) was released in the brain after stimulation by an aversive taste and might be involved in the aversive sensations of taste.
Localization (released) of DBI in brain
3) Confidence 0.80 Published 2002 Journal J. Nutr. Sci. Vitaminol. Section Abstract Doc Link 12171440 Disease Relevance 0.18 Pain Relevance 0.09
A positive correlation between beta-EP in blood and placenta during heat and naloxone administration suggests that increased placental beta-EP during heat results in hypersecretion of beta-EP into blood.
Localization (hypersecretion) of beta-EP in placenta associated with narcan
4) Confidence 0.76 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9530232 Disease Relevance 0.22 Pain Relevance 0.52
The results indicated that AA could obviously stimulate the release of beta-EP from pituitary cells at a concentration of 2 x 10(-5) mol/L, while cortisol at 10(-6)mol/L and DEX at 10(-7)mol/L inhibited this release.
Localization (release) of beta-EP in pituitary associated with dexamethasone
5) Confidence 0.73 Published 1994 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Abstract Doc Link 7954966 Disease Relevance 0 Pain Relevance 0.14
As with poly (ICLC), liposome-encapsulation of CpG ODNs has been used to reduce toxicity and prolong exposure due to gradual release of the CpG ODN from liposomes [132, 151].
Localization (release) of ODN in poly associated with toxicity
6) Confidence 0.73 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 1.33 Pain Relevance 0.10
The results indicate that i.v.t. beta-EP is more potent than MS in causing the release of pituitary ACTH and beta-EP.
Localization (release) of beta-EP in pituitary
7) Confidence 0.72 Published 1981 Journal Neuroendocrinology Section Abstract Doc Link 6270585 Disease Relevance 0 Pain Relevance 0.17
To characterize the effect of ethanol on the hypothalamic beta-endorphin-containing neurons, rat fetal hypothalamic neurons were maintained in primary culture, and the secretion of beta-endorphin (beta-EP) was determined after ethanol challenges.
Spec (determined) Localization (secretion) of beta-EP in neurons
8) Confidence 0.70 Published 1990 Journal Life Sci. Section Abstract Doc Link 2215079 Disease Relevance 0 Pain Relevance 0
Constant exposure to ethanol at doses of 6-50 mM produced a dose-dependent increase in basal secretion of beta-EP from these cultured cells.
Localization (secretion) of beta-EP
9) Confidence 0.70 Published 1990 Journal Life Sci. Section Abstract Doc Link 2215079 Disease Relevance 0 Pain Relevance 0.05
DBI is also released by veratridine depolarization, in a tetrodotoxin-sensitive fashion, from primary cultures of cerebral cortical neurons, but not from cortical astrocytes.
Neg (not) Localization (released) of DBI in astrocytes associated with tetrodotoxin
10) Confidence 0.70 Published 1987 Journal J. Neurochem. Section Abstract Doc Link 3819722 Disease Relevance 0 Pain Relevance 0.43
These data support the view that DBI may be released as a putative neuromodulatory substance from rat brain neurons.
Localization (released) of DBI in neurons
11) Confidence 0.70 Published 1987 Journal J. Neurochem. Section Abstract Doc Link 3819722 Disease Relevance 0 Pain Relevance 0.39
In conclusion, repeated administration of KT showed no impairment of Ep production and release in response to reduced hematocrit, suggesting that in this instance, prostaglandin inhibition plays a minimal role in Ep production or release.
Localization (release) of Ep
12) Confidence 0.69 Published 1994 Journal Int J Artif Organs Section Abstract Doc Link 7759142 Disease Relevance 0.08 Pain Relevance 0.07
In conclusion, repeated administration of KT showed no impairment of Ep production and release in response to reduced hematocrit, suggesting that in this instance, prostaglandin inhibition plays a minimal role in Ep production or release.
Localization (release) of Ep
13) Confidence 0.69 Published 1994 Journal Int J Artif Organs Section Abstract Doc Link 7759142 Disease Relevance 0.08 Pain Relevance 0.07
When incubated with pituitary cells, lanthanum chloride induced a dose- and time-dependent release of beta-EP.
Localization (release) of beta-EP in pituitary
14) Confidence 0.64 Published 1994 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Abstract Doc Link 7954966 Disease Relevance 0 Pain Relevance 0.19
The objective of the present studies was to investigate the effects of various concentrations of ethanol on the in vitro release of beta-EP peptides by the hypothalami of the ethanol-preferring Alko-Alcohol (AA) and ethanol-avoiding Alko Non-Alcohol (ANA) lines of rats.
Localization (release) of beta-EP associated with alcohol
15) Confidence 0.63 Published 1994 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 7695046 Disease Relevance 0 Pain Relevance 0.33
Depolarization fails to release DBI from slices of liver and other peripheral organs.
Localization (release) of DBI in liver
16) Confidence 0.62 Published 1987 Journal J. Neurochem. Section Abstract Doc Link 3819722 Disease Relevance 0 Pain Relevance 0.40
Depolarization induced by high K+ levels (50 mM) or veratridine (50 microM) released DBI stored in neurons of superfused slices of hypothalamus, hippocampus, striatum, and cerebral cortex.
Localization (released) of DBI in striatum associated with hippocampus and cerebral cortex
17) Confidence 0.62 Published 1987 Journal J. Neurochem. Section Abstract Doc Link 3819722 Disease Relevance 0 Pain Relevance 0.37
Ethanol-stimulated beta-EP secretion required extracellular calcium and was blocked by a calcium channel blocker; a sodium channel blocker did not affect ethanol-stimulated secretion.
Localization (secretion) of beta-EP associated with calcium channel and sodium channel
18) Confidence 0.61 Published 1990 Journal Life Sci. Section Abstract Doc Link 2215079 Disease Relevance 0 Pain Relevance 0.17
However, intermittent ethanol exposures maintained the ethanol stimulatory action on beta-EP secretion for a longer time.
Localization (secretion) of beta-EP
19) Confidence 0.61 Published 1990 Journal Life Sci. Section Abstract Doc Link 2215079 Disease Relevance 0 Pain Relevance 0.14
The effects of intraventricular (i.v.t.) morphine sulfate (MS) and beta-endorphin (beta-EP) on pituitary-adrenal activity and the release of pituitary beta-EP were studied in rats.
Localization (release) of beta-EP in pituitary associated with morphine
20) Confidence 0.59 Published 1981 Journal Neuroendocrinology Section Abstract Doc Link 6270585 Disease Relevance 0 Pain Relevance 0.17

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