INT59884

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Context Info
Confidence 0.78
First Reported 1993
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.32
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (UMOD) extracellular region (UMOD) Golgi apparatus (UMOD)
plasma membrane (UMOD)
Anatomy Link Frequency
loop of Henle 1
UMOD (Homo sapiens)
Pain Link Frequency Relevance Heat
interstitial cystitis 8 98.76 Very High Very High Very High
Inflammatory mediators 3 74.88 Quite High
Arthritis 38 70.28 Quite High
Inflammation 33 64.68 Quite High
rheumatoid arthritis 10 52.72 Quite High
Analgesic 1 33.20 Quite Low
cytokine 5 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 84 99.12 Very High Very High Very High
Interstitial Cystitis 8 98.76 Very High Very High Very High
Alpha-1-antitrypsin Deficiency 5 96.12 Very High Very High Very High
Chronic Renal Failure 98 81.72 Quite High
INFLAMMATION 37 74.48 Quite High
Renal Disease 5 74.32 Quite High
Diabetes Mellitus 33 70.68 Quite High
Arthritis 35 70.28 Quite High
Amyloidosis 2 61.60 Quite High
Urinary Tract Infection 2 59.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together, these results make it unlikely that immunohistochemical detection of Tamm-Horsfall protein will have diagnostic value in interstitial cystitis.
Gene_expression (detection) of Tamm-Horsfall protein associated with interstitial cystitis
1) Confidence 0.78 Published 1993 Journal J. Urol. Section Abstract Doc Link 8411410 Disease Relevance 0.85 Pain Relevance 0.66
However, UMOD protein is not derived from blood, but is produced by the thick ascending limb of the loop of Henle in kidney.
Gene_expression (produced) of UMOD in loop of Henle
2) Confidence 0.62 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.96 Pain Relevance 0.16
No interaction was found between the UMOD variant and sex (P?
Gene_expression (sex) of UMOD variant
3) Confidence 0.57 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2912386 Disease Relevance 0.25 Pain Relevance 0
No interaction was found between the UMOD variant and sex (P?
Neg (No) Gene_expression (found) of UMOD variant
4) Confidence 0.57 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2912386 Disease Relevance 0.25 Pain Relevance 0

General Comments

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