INT5989

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Context Info
Confidence 0.49
First Reported 1980
Last Reported 2011
Negated 3
Speculated 1
Reported most in Abstract
Documents 79
Total Number 80
Disease Relevance 24.38
Pain Relevance 32.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Dbi) transport (Dbi) mitochondrion (Dbi)
extracellular space (Dbi) plasma membrane (Dbi) nucleus (Dbi)
Anatomy Link Frequency
plasma 14
blood 6
PVH 4
VMH 4
brain 2
Dbi (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 62 100.00 Very High Very High Very High
Enkephalin 45 100.00 Very High Very High Very High
antagonist 53 99.98 Very High Very High Very High
Pain 47 99.74 Very High Very High Very High
dorsal root ganglion 30 99.72 Very High Very High Very High
Nucleus accumbens 26 99.68 Very High Very High Very High
alcohol 21 99.68 Very High Very High Very High
Morphine 12 99.64 Very High Very High Very High
Pain threshold 13 99.62 Very High Very High Very High
Migraine 5 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Brain Injury 75 100.00 Very High Very High Very High
Stress 35 99.84 Very High Very High Very High
Diabetes Mellitus 62 99.82 Very High Very High Very High
Pain 45 99.74 Very High Very High Very High
Ganglion Cysts 33 99.72 Very High Very High Very High
Headache 7 99.56 Very High Very High Very High
Shock 2 99.48 Very High Very High Very High
Urological Neuroanatomy 65 99.34 Very High Very High Very High
Obesity 8 98.28 Very High Very High Very High
Disease 123 98.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasma Ep levels were significantly higher in the KT rats than normal controls with the greatest difference occurring on d4 of treatment (70.1 +/- 10.8 vs 30.9 +/- 10.84 mU/ml, p < 0.01).
Positive_regulation (higher) of Ep in Plasma
1) Confidence 0.49 Published 1994 Journal Int J Artif Organs Section Abstract Doc Link 7759142 Disease Relevance 0.15 Pain Relevance 0.31
Encapsulation of CpG ODNs within large (1.5 ?
Positive_regulation (Encapsulation) of ODN
2) Confidence 0.49 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.88 Pain Relevance 0.05
When compared with that in the DBI alone group the number of group I mGluR positive neurons increased significantly in the DBI with SBI group.
Positive_regulation (increased) of DBI in neurons associated with brain injury
3) Confidence 0.46 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2242800 Disease Relevance 0.98 Pain Relevance 0
Activation of the sodium channel by veratridine (100 microM) also increased the medium content of IR-beta EP, and this effect was blocked by tetrodotoxin (1 microM).
Positive_regulation (increased) of EP associated with tetrodotoxin and sodium channel
4) Confidence 0.45 Published 1990 Journal Endocrinology Section Abstract Doc Link 2136725 Disease Relevance 0 Pain Relevance 0.22
It was hypothesised that exercised rats would demonstrate increased beta-endorphin (beta EP) levels and decreased exogenous opiate intake.
Positive_regulation (increased) of beta EP associated with opiate
5) Confidence 0.43 Published 1994 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 8090833 Disease Relevance 0 Pain Relevance 0.99
The diabetes-induced increases in Dbi and Anxa5 protein and mRNA expression were completely normalized (Figure 8).
Positive_regulation (increases) of Dbi associated with diabetes mellitus
6) Confidence 0.42 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.39 Pain Relevance 0
Significant increases in blood and placental beta-EP induced by both heat and naloxone administration and a significant interaction on blood and placental beta-EP was observed.
Positive_regulation (increases) of beta-EP in blood associated with narcan
7) Confidence 0.39 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9530232 Disease Relevance 0.24 Pain Relevance 0.59
A positive correlation between beta-EP in blood and placenta during heat and naloxone administration suggests that increased placental beta-EP during heat results in hypersecretion of beta-EP into blood.
Positive_regulation (increased) of beta-EP in placenta associated with narcan
8) Confidence 0.39 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9530232 Disease Relevance 0.23 Pain Relevance 0.54
Significant increases in blood and placental beta-EP induced by both heat and naloxone administration and a significant interaction on blood and placental beta-EP was observed.
Positive_regulation (increases) of beta-EP in blood associated with narcan
9) Confidence 0.39 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9530232 Disease Relevance 0.24 Pain Relevance 0.58
Two-way analysis of variance revealed significant increases in blood beta-EP induced by heat and naloxone and a significant interaction between heat and naloxone on blood beta-EP and progesterone (P).
Positive_regulation (increases) of beta-EP in blood associated with narcan
10) Confidence 0.39 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9530232 Disease Relevance 0.22 Pain Relevance 0.56
The above results suggest that melatonin may result in a decrease of beta-Ep content in the arcuate nucleus, as a result of increased beta-Ep release induced by administration of melatonin.
Positive_regulation (increased) of beta-Ep in arcuate nucleus
11) Confidence 0.38 Published 2000 Journal Sheng Li Xue Bao Section Abstract Doc Link 11956578 Disease Relevance 0 Pain Relevance 0.16
Furthermore, decreased feeding responses to 2-DG could coexist with increased levels of plasma ir-beta-EP in NaCl-treated normal rats.
Positive_regulation (increased) of beta-EP in plasma
12) Confidence 0.35 Published 1985 Journal Peptides Section Abstract Doc Link 2933639 Disease Relevance 0.49 Pain Relevance 0.18
Thus, elevations in plasma ir-beta-EP are not necessary for the full expression of 2-DG-induced hyperphagia in dexamethasone-treated rats.
Positive_regulation (elevations) of beta-EP in plasma associated with hyperphagia and dexamethasone
13) Confidence 0.35 Published 1985 Journal Peptides Section Abstract Doc Link 2933639 Disease Relevance 0.53 Pain Relevance 0.17
It is concluded from this structure activity relationship study that the activation of the beta-EP receptor involves at least two sites of recognition on the beta-EP structure.
Positive_regulation (activation) of beta-EP
14) Confidence 0.34 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6123591 Disease Relevance 0 Pain Relevance 0.73
The depolarization-induced IR-beta EP release was dependent upon calcium, since a calcium channel blocker, verapamil (0.1 microM), prevented the release; also a calcium ionophore, A23187 (1 microM), stimulated IR-beta EP release in the cultures.
Positive_regulation (depolarization-induced) of EP associated with calcium channel
15) Confidence 0.32 Published 1990 Journal Endocrinology Section Abstract Doc Link 2136725 Disease Relevance 0 Pain Relevance 0.19
Also, an injection of alcohol caused a delayed increase of beta-EP in the NAcb but not the ArcN, indicating that alcohol may recruit a mechanism that is, at least partially, distinct from stress-related pathways.
Positive_regulation (increase) of beta-EP in NAcb associated with stress, nucleus accumbens and alcohol
16) Confidence 0.32 Published 2004 Journal Neuroscience Section Abstract Doc Link 15283974 Disease Relevance 0.32 Pain Relevance 0.42
In culture, there was a progressive increase in immunoreactive beta EP (IR-beta EP) in both cells and media, reaching maximum values at 12-16 days.
Positive_regulation (increase) of EP
17) Confidence 0.30 Published 1990 Journal Endocrinology Section Abstract Doc Link 2136725 Disease Relevance 0 Pain Relevance 0.04
In culture, there was a progressive increase in immunoreactive beta EP (IR-beta EP) in both cells and media, reaching maximum values at 12-16 days.
Positive_regulation (increase) of EP
18) Confidence 0.30 Published 1990 Journal Endocrinology Section Abstract Doc Link 2136725 Disease Relevance 0 Pain Relevance 0.04
This treatment induced a significant increase in medium IR-beta EP.
Positive_regulation (increase) of EP
19) Confidence 0.30 Published 1990 Journal Endocrinology Section Abstract Doc Link 2136725 Disease Relevance 0 Pain Relevance 0.19
Parachlorophenylalanine, which inhibits 5-HT synthesis, significantly elevated beta-Ep in all brain parts studied.
Positive_regulation (elevated) of beta-Ep in brain
20) Confidence 0.29 Published 1986 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 3010328 Disease Relevance 0.36 Pain Relevance 0.44

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