INT59891

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Context Info
Confidence 0.67
First Reported 1993
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 46
Total Number 46
Disease Relevance 17.66
Pain Relevance 5.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peroxisome (GSTK1) intracellular (GSTK1)
Anatomy Link Frequency
bladder 4
liver 3
Urine 3
colon 2
small intestine 2
GSTK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 50 99.98 Very High Very High Very High
qutenza 30 99.72 Very High Very High Very High
Inflammation 89 98.88 Very High Very High Very High
vincristine 2 98.80 Very High Very High Very High
Chronic pancreatitis 22 97.96 Very High Very High Very High
Paracetamol 11 96.32 Very High Very High Very High
tolerance 46 83.52 Quite High
dexamethasone 1 80.52 Quite High
agonist 2 78.08 Quite High
Potency 8 52.32 Quite High
Disease Link Frequency Relevance Heat
Stress 226 99.92 Very High Very High Very High
Cancer 473 99.76 Very High Very High Very High
Prostate Cancer 168 99.36 Very High Very High Very High
Pancreatic Cancer 108 99.28 Very High Very High Very High
Disease 70 99.12 Very High Very High Very High
Infection 76 98.94 Very High Very High Very High
Recurrence 8 98.92 Very High Very High Very High
INFLAMMATION 115 98.88 Very High Very High Very High
Breast Cancer 137 98.76 Very High Very High Very High
Fungal Infection 54 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GST activity and GST mu levels were increased (1.2-1.8 x) in oesophagus and small intestine by indomethacin, ibuprofen, piroxicam and sulindac.
Positive_regulation (increased) of GST in small intestine
1) Confidence 0.67 Published 1997 Journal Carcinogenesis Section Abstract Doc Link 9067546 Disease Relevance 0.28 Pain Relevance 0.28
GST alpha levels were induced (1.2-2.8 x) in stomach by piroxicam, in small intestine by indomethacin, ibuprofen, piroxicam and sulindac, and in liver by piroxicam.
Positive_regulation (induced) of GST in stomach
2) Confidence 0.67 Published 1997 Journal Carcinogenesis Section Abstract Doc Link 9067546 Disease Relevance 0.26 Pain Relevance 0.32
GST activity and GST mu levels were increased (1.2-1.8 x) in oesophagus and small intestine by indomethacin, ibuprofen, piroxicam and sulindac.
Positive_regulation (increased) of GST in small intestine
3) Confidence 0.67 Published 1997 Journal Carcinogenesis Section Abstract Doc Link 9067546 Disease Relevance 0.28 Pain Relevance 0.28
Levels of GST 5-5 were also induced in the islets.
Positive_regulation (induced) of GST
4) Confidence 0.58 Published 1993 Journal J. Pathol. Section Abstract Doc Link 8501544 Disease Relevance 0.79 Pain Relevance 0.39
In material from patients with chronic pancreatitis or pancreatic cancer, cytochrome P-450 enzyme levels were greater in both the liver and the pancreas than those seen in the donor group, while GST levels were unchanged.
Neg (unchanged) Positive_regulation (unchanged) of GST in pancreas associated with pancreatic cancer and chronic pancreatitis
5) Confidence 0.39 Published 1993 Journal J. Pathol. Section Abstract Doc Link 8501544 Disease Relevance 0.94 Pain Relevance 0.47
Acetaminophen exposure significantly increased hepatic LPO levels and inhibited AChE activity in gill (10-day NOEC and LOEC of 23 and 403 microg/L, respectively), whereas propranolol (11 microg/L) enhanced gill GST.
Positive_regulation (enhanced) of GST in gill associated with paracetamol
6) Confidence 0.32 Published 2010 Journal Anal Bioanal Chem Section Abstract Doc Link 19838684 Disease Relevance 0.15 Pain Relevance 0.38
Neither was there any evidence of an induction of HO-1 protein or increased GST activity post wood smoke, table 3.
Positive_regulation (induction) of GST
7) Confidence 0.30 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2936868 Disease Relevance 0.21 Pain Relevance 0
Animal studies have demonstrated that oltipraz is a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST).
Positive_regulation (inducer) of GST
8) Confidence 0.29 Published 1993 Journal J. Cell. Biochem. Suppl. Section Abstract Doc Link 8412206 Disease Relevance 0.06 Pain Relevance 0
GST activity and GST mu levels were increased (1.2-1.8 x) in oesophagus and small intestine by indomethacin, ibuprofen, piroxicam and sulindac.
Positive_regulation (increased) of GST in oesophagus
9) Confidence 0.23 Published 1997 Journal Carcinogenesis Section Abstract Doc Link 9067546 Disease Relevance 0.28 Pain Relevance 0.28
GST activity and GST mu levels were increased (1.2-1.8 x) in oesophagus and small intestine by indomethacin, ibuprofen, piroxicam and sulindac.
Positive_regulation (increased) of GST in oesophagus
10) Confidence 0.23 Published 1997 Journal Carcinogenesis Section Abstract Doc Link 9067546 Disease Relevance 0.28 Pain Relevance 0.28
There is an absence of data regarding this issue, although earlier work did show that prevention of breast cancer relapse with radiation therapy was greatest among women with elevated levels of GST ?
Positive_regulation (elevated) of GST associated with breast cancer and recurrence
11) Confidence 0.22 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779469 Disease Relevance 0.85 Pain Relevance 0
Taken together, the present findings indicate a potential mobilisation of glutathione to the air-lung interface in the absence of inflammatory cell recruitment into the airways, oxidative stress or induction of mucosal xenobiotic enzymes (HO-1 and GST).
Positive_regulation (induction) of GST in lung associated with stress and inflammation
12) Confidence 0.20 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2936868 Disease Relevance 0.44 Pain Relevance 0.09
Neither was there any evidence of an induction of HO-1 protein or increased GST activity post wood smoke, table 3.
Positive_regulation (increased) of GST
13) Confidence 0.20 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2936868 Disease Relevance 0.21 Pain Relevance 0
In pilot studies, gavage with capsaicin and rotenone elevated the phase II enzymes glutathione S-transferase (GST) and quinone reductase (QR), in the liver and tongue.
Positive_regulation (elevated) of GST in tongue associated with qutenza
14) Confidence 0.17 Published 2002 Journal Carcinogenesis Section Abstract Doc Link 12151355 Disease Relevance 0.08 Pain Relevance 0.36
Significant destabilization of the lysosomal membrane from baseline levels was evident at 5 and 10nM at the end of the exposures, as was a high induction capacity of the activities of CAT and GST.
Positive_regulation (induction) of GST
15) Confidence 0.15 Published 2010 Journal Chemosphere Section Abstract Doc Link 20227746 Disease Relevance 0.16 Pain Relevance 0.07
The lack of treatment effects on gst expression in females may relate to their higher levels of endogenous estrogen that, in turn, are likely to account for the lower gst levels observed in females compared with males, and may render them less sensitive to induction/inhibition by exogenous chemicals.
Positive_regulation (account) of gst
16) Confidence 0.14 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137123 Disease Relevance 0.07 Pain Relevance 0.04
Gavage with capsaicin and rotenone significantly elevated phase II enzymes, glutathione S-transferase (GST) and quinone reductase (QR), in the liver and colon.
Positive_regulation (elevated) of GST in colon associated with qutenza
17) Confidence 0.14 Published 2001 Journal Int. J. Oncol. Section Abstract Doc Link 11604990 Disease Relevance 0.43 Pain Relevance 0.40
Furthermore, modest induction of phase 2 enzymes (NQO1 and total GST), virtually identical to those reported in the present study, have been observed in the liver tissues of F344 rats treated with sulforaphane and sulforaphane nitrile derived from cruciferous vegetables [26].
Positive_regulation (induction) of GST in liver
18) Confidence 0.13 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1421427 Disease Relevance 0.65 Pain Relevance 0
The degree of increase of NQO1, total GST and GST-mu enzymatic activities in the prostate tissues we observed was modest, and lower than that reported in other model systems where phase 2 enzyme inducing compounds have been documented to prevent carcinogenesis [25].
Positive_regulation (increase) of GST
19) Confidence 0.13 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1421427 Disease Relevance 0.66 Pain Relevance 0
One notable finding was the significant induction of total GST and NQO1 enzymatic activities in bladder tissues of the F344 rats.
Positive_regulation (induction) of GST in bladder
20) Confidence 0.13 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1421427 Disease Relevance 0.86 Pain Relevance 0

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