INT59899

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 1993
Last Reported 2008
Negated 0
Speculated 3
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 7.61
Pain Relevance 1.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MATN3) proteinaceous extracellular matrix (MATN3)
Anatomy Link Frequency
joints 1
MATN3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 96 100.00 Very High Very High Very High
headache 16 88.20 High High
Inflammation 24 85.00 Quite High
Pain 53 84.20 Quite High
withdrawal 2 68.84 Quite High
backache 2 67.92 Quite High
fibrosis 1 61.72 Quite High
Arthritis 5 51.08 Quite High
Pain scale 22 29.56 Quite Low
Pain score 2 19.88 Low Low
Disease Link Frequency Relevance Heat
Osteochondrodysplasias 176 100.00 Very High Very High Very High
Osteoarthropathy 56 100.00 Very High Very High Very High
Disease 99 98.92 Very High Very High Very High
Malignant Neoplastic Disease 5 98.68 Very High Very High Very High
Osteoarthritis 56 95.04 Very High Very High Very High
Congenital Anomalies 1 94.88 High High
Cleidocranial Dysplasia 16 94.28 High High
Carcinoma 4 92.08 High High
Cancer 3 90.72 High High
Lung Cancer 1 90.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine the effects of MATN3 mutations on the structure and function of matrilin-3 we expressed both normal and mutant matrilin-3 in mammalian cells.
Spec (determine) Regulation (effects) of matrilin
1) Confidence 0.45 Published 2005 Journal Human Mutation Section Abstract Doc Link PMC2726956 Disease Relevance 0.81 Pain Relevance 0.13
To understand the effect of MED-causing mutations on the structure and function of matrilin-3 and thereby gain insight into the disease mechanisms of this form of MED, we expressed both normal and mutant full-length matrilin-3 proteins and single A-domains in mammalian cells.
Regulation (effect) of matrilin associated with osteochondrodysplasias and disease
2) Confidence 0.45 Published 2005 Journal Human Mutation Section Body Doc Link PMC2726956 Disease Relevance 0.84 Pain Relevance 0.04
This approach allowed us to investigate the effects of mutations on the folding and trafficking of matrilin-3 and propose a potential disease mechanism for this form of MED.


Spec (investigate) Regulation (effects) of matrilin associated with osteochondrodysplasias and disease
3) Confidence 0.45 Published 2005 Journal Human Mutation Section Body Doc Link PMC2726956 Disease Relevance 0.88 Pain Relevance 0.04
To determine the effects of MATN3 mutations on the structure and function of matrilin-3 we expressed both normal and mutant matrilin-3 in mammalian cells.
Spec (determine) Regulation (effects) of MATN3
4) Confidence 0.45 Published 2005 Journal Human Mutation Section Abstract Doc Link PMC2726956 Disease Relevance 0.81 Pain Relevance 0.13
Many authors mention the predictive value of HOA, especially in association with malignant tumors.
Regulation (value) of HOA associated with malignant neoplastic disease and osteoarthropathy
5) Confidence 0.23 Published 1993 Journal Med. Pediatr. Oncol. Section Abstract Doc Link 8413003 Disease Relevance 2.37 Pain Relevance 0.11
This placebo-controlled phase 2 study suggests that the combination is effective in patients with HOA.
Regulation (effective) of HOA associated with osteoarthritis
6) Confidence 0.08 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564788 Disease Relevance 0.70 Pain Relevance 0.51
In HOA the DIP and PIP joints as well as the first carpometacarpal (CMC) joint are particularly affected,27 but patients with HOA tend to have involvement of multiple joints, a condition that is often referred to as generalised OA.28 The joints most frequently involved in this study population were the first metatarsophalangeal (MTP) joint, the knee and additionally the lumbar and cervical spine (table 1).
Regulation (affected) of HOA in joints associated with osteoarthritis
7) Confidence 0.05 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564788 Disease Relevance 1.20 Pain Relevance 0.64

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox