INT59900

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Context Info
Confidence 0.42
First Reported 1993
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 15
Disease Relevance 17.19
Pain Relevance 3.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MATN3) proteinaceous extracellular matrix (MATN3)
Anatomy Link Frequency
chondrocytes 1
articular 1
lung 1
bowel 1
wrists 1
MATN3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 51 100.00 Very High Very High Very High
fibrosis 5 99.48 Very High Very High Very High
Opioid 1 99.12 Very High Very High Very High
Analgesic 2 98.92 Very High Very High Very High
Inflammation 16 98.52 Very High Very High Very High
agonist 3 97.84 Very High Very High Very High
Potency 1 97.52 Very High Very High Very High
Pain 45 97.24 Very High Very High Very High
Enkephalin 1 96.96 Very High Very High Very High
Arthritis 5 96.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Osteoarthropathy 109 100.00 Very High Very High Very High
Arthralgia 16 100.00 Very High Very High Very High
Pressure And Volume Under Development 13 100.00 Very High Very High Very High
Malignant Neoplastic Disease 12 100.00 Very High Very High Very High
Skin Appendage Disease 8 100.00 Very High Very High Very High
Syndrome 6 100.00 Very High Very High Very High
Bronchogenic Carcinoma 6 99.76 Very High Very High Very High
Cystic Fibrosis 5 99.76 Very High Very High Very High
Disease 79 99.60 Very High Very High Very High
Lung Cancer 9 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The familial or idiopathic HOA (pachydermoperiostosis) appears at puberty and is not associated with other underlying diseases.
HOA Binding (associated) of associated with osteoarthropathy and disease
1) Confidence 0.42 Published 2009 Journal Pol. Arch. Med. Wewn. Section Abstract Doc Link 19776708 Disease Relevance 1.19 Pain Relevance 0.09
Primary familial HOA is very rare and is not associated with underlying disorders and has a good prognosis.
HOA Binding (associated) of associated with osteoarthropathy
2) Confidence 0.41 Published 2009 Journal Clin Nucl Med Section Abstract Doc Link 19352278 Disease Relevance 1.50 Pain Relevance 0.16
Secondary pediatric nonneoplastic HOA is associated with cystic fibrosis, congenital heart disease, biliary atresia, and inflammatory bowel disease.
HOA Binding (associated) of in bowel associated with fibrosis, biliary atresia, osteoarthropathy, inflammation, cystic fibrosis and coronary heart disease
3) Confidence 0.41 Published 2009 Journal Clin Nucl Med Section Abstract Doc Link 19352278 Disease Relevance 1.57 Pain Relevance 0.18
Recently there has been much speculation about the reason for this genetic heterogeneity, and a number of hypotheses have been suggested; i.e., 1) some mutations disrupt specific interactions between matrilin-3, type IX collagen, and COMP in the cartilage ECM [Briggs and Chapman, 2002]; 2) the blocked/delayed secretion of one mutant protein results in a cascade of protein retention within the rER of chondrocytes [Unger and Hecht, 2001]; or 3) a combination of both mechanisms [Dinser et al., 2002].
matrilin Binding (interactions) of in chondrocytes
4) Confidence 0.37 Published 2005 Journal Human Mutation Section Body Doc Link PMC2726956 Disease Relevance 0.37 Pain Relevance 0
In addition disulfide bonded dimers and trimers were also detected, suggesting a potential mechanism for the aggregation of misfolded matrilin-3 within the rER.
matrilin Binding (aggregation) of
5) Confidence 0.37 Published 2005 Journal Human Mutation Section Body Doc Link PMC2726956 Disease Relevance 0.24 Pain Relevance 0
, Sfi I restriction site underlined) and MATN3ex2R (5?
MATN3 Binding (underlined) of
6) Confidence 0.36 Published 2005 Journal Human Mutation Section Body Doc Link PMC2726956 Disease Relevance 0.68 Pain Relevance 0.03
DiPOA bound competitively to the opioid binding site of human mu receptors as demonstrated by a parallel rightward shift in its concentration-response curve in the presence of increasing concentrations of naltrexone.
DiPOA Binding (bound) of associated with opioid
7) Confidence 0.33 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15054115 Disease Relevance 0.06 Pain Relevance 0.82
We present a patient with HOA of the lower extremities and wrists that developed after bronchogenic carcinoma.
HOA Binding (patient) of in wrists associated with bronchogenic carcinoma and osteoarthropathy
8) Confidence 0.32 Published 2008 Journal Clin Lung Cancer Section Abstract Doc Link 18621629 Disease Relevance 1.27 Pain Relevance 0.29
Hypertrophic osteoarthropathy (HOA) is a syndrome characterized by digital clubbing, arthralgias, and tissue swelling and is frequently described in association with bronchogenic carcinoma.
HOA Binding (association) of associated with pressure and volume under development, arthralgia, skin appendage disease, bronchogenic carcinoma, osteoarthropathy and syndrome
9) Confidence 0.32 Published 2008 Journal Clin Lung Cancer Section Abstract Doc Link 18621629 Disease Relevance 1.27 Pain Relevance 0.27
We present the case of a 58-year-old male with HOA, associated with spinocellular lung cancer, who survived 25 years after pneumonectomy.
HOA Binding (associated) of in lung associated with lung cancer and osteoarthropathy
10) Confidence 0.31 Published 2009 Journal Pol. Arch. Med. Wewn. Section Abstract Doc Link 19776708 Disease Relevance 1.33 Pain Relevance 0.08
A meticulous research of the literature from 1890 to 1990 revealed only 24 children (19 boys, 5 girls) under the age of 18, with malignancy and associated HOA.
HOA Binding (associated) of associated with malignant neoplastic disease and osteoarthropathy
11) Confidence 0.31 Published 1993 Journal Med. Pediatr. Oncol. Section Abstract Doc Link 8413003 Disease Relevance 2.37 Pain Relevance 0.14
Secondary neoplastic HOA may be associated with intra or extrathoracic tumors.A 5-year-old girl was admitted to our hospital for an abdominal mass, digital clubbing, and diffuse articular pain.
HOA Binding (associated) of in articular associated with pain, arthralgia, skin appendage disease, osteoarthropathy and cancer
12) Confidence 0.31 Published 2009 Journal Clin Nucl Med Section Abstract Doc Link 19352278 Disease Relevance 1.61 Pain Relevance 0.19
The association of malignant disorders with HOA is more common in adults than in children.
HOA Binding (association) of associated with malignant neoplastic disease and osteoarthropathy
13) Confidence 0.31 Published 1997 Journal Med. Pediatr. Oncol. Section Abstract Doc Link 9324349 Disease Relevance 0.63 Pain Relevance 0.15
Pulmonary shunting caused by the several disease processes that are associated with HOA causes a faulty pulmonary clearance of macrothrombocytes, which release growth factors in the systemic circulation.
HOA Binding (associated) of associated with osteoarthropathy and disease
14) Confidence 0.27 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2323011 Disease Relevance 1.30 Pain Relevance 0.09
Knee OA is the most common form of the disease, followed by hand OA (HOA).3 The majority of people aged 55 years and over have radiographic changes of OA in at least one hand joint and approximately one-fifth of this population has symptomatic HOA.4 5 The prevalence of HOA increases with age and is higher in females than in males. 4 Recent studies also indicate that the burden of disease for patients with HOA is considerable across a variety of dimensions of health-related quality of life.6
HOA Binding (higher) of in Knee associated with disease and osteoarthritis
15) Confidence 0.06 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564788 Disease Relevance 1.80 Pain Relevance 1.11

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