INT59905

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Context Info
Confidence 0.63
First Reported 1993
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 29
Total Number 31
Disease Relevance 9.25
Pain Relevance 2.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ghr) extracellular space (Ghr) extracellular region (Ghr)
plasma membrane (Ghr) nucleus (Ghr) cytoplasm (Ghr)
Anatomy Link Frequency
liver 3
plasma 1
choroid plexus 1
somatotroph 1
skeletal muscle 1
Ghr (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 63 99.90 Very High Very High Very High
tolerance 44 99.00 Very High Very High Very High
opiate 1 97.98 Very High Very High Very High
Hippocampus 87 97.44 Very High Very High Very High
Thalamus 56 96.56 Very High Very High Very High
Morphine 3 90.40 High High
amygdala 7 83.76 Quite High
Spinal cord 17 78.16 Quite High
cytokine 31 76.00 Quite High
Opioid 1 75.80 Quite High
Disease Link Frequency Relevance Heat
Hyperinsulinism 18 99.98 Very High Very High Very High
Obesity 73 99.90 Very High Very High Very High
Targeted Disruption 412 99.58 Very High Very High Very High
Htlv Types I And Ii 6 99.22 Very High Very High Very High
Body Weight 103 98.56 Very High Very High Very High
Stress 243 98.12 Very High Very High Very High
Weight Loss 15 97.32 Very High Very High Very High
Acromegaly 162 96.84 Very High Very High Very High
Lifespan 305 94.52 High High
Hyperglycemia 6 93.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is possible that some disparity between differential expression signatures of GHR-KO and Little mice can be attributed to technical differences in sample preparation and array hybridizations.
Gene_expression (expression) of GHR
1) Confidence 0.63 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.15 Pain Relevance 0
Interestingly, the normal serum GH levels together with the significant systemic down regulation of GH receptor gene expression likely point to growth hormone resistance in 15-d-old Csbm/m/Xpa?
Gene_expression (expression) of GH receptor
2) Confidence 0.57 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1698505 Disease Relevance 0.16 Pain Relevance 0
Moreover, the GIR was significantly higher in KO mice compared to WT (7.76 ± 1.65 vs 5.68 ± 1.52 mg/kg/min, Figure 2C), indicative of increased insulin sensitivity of the GhrR KO mice.
Gene_expression (sensitivity) of GhrR associated with hyperinsulinism
3) Confidence 0.56 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.86 Pain Relevance 0
Preliminary experiments were performed comparing diet-induced obese (DIO) vs lean mice prior to conducting experiments on HFD-fed GhrR KO vs WT mice (Figure 1).


Gene_expression (lean) of GhrR associated with obesity
4) Confidence 0.56 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.43 Pain Relevance 0
This difference does not reflect sample size and statistical power disparities between experiments (see Table 2), and moreover, agrees with an earlier study that found very few genes (10 of 2352) differentially expressed between GHR-KO mice and normal controls [23].
Gene_expression (expressed) of GHR
5) Confidence 0.55 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.14 Pain Relevance 0
GHR-KI1 mice lack GHR residue 569, but exhibit only slight loss of hepatic IGF-1 transcript because STAT5 signaling is partially functional [26].
Gene_expression (residue) of GHR
6) Confidence 0.55 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0 Pain Relevance 0
This is because GHR-KO mice exhibited significant IGF-I transcript downregulation of larger magnitude than that observed in the Snell, Ames and Little models, but nevertheless, only 46 genes exhibited differential expression in GHR-KO mice (see Table 2).
Gene_expression (expression) of GHR
7) Confidence 0.55 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.05 Pain Relevance 0
This was not the case, however, given that 500–600 genes were differentially expressed with respect to Little mice, while fewer than 50 genes were differentially expressed with respect to GHR-KO mice.
Gene_expression (expressed) of GHR
8) Confidence 0.55 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.19 Pain Relevance 0
GHR is highly expressed in most areas of the CNS, in particular in the choroid plexus, hippocampus, putamen, thalamus and hypothalamus.
Gene_expression (expressed) of GHR in hippocampus associated with thalamus and hippocampus
9) Confidence 0.55 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.57 Pain Relevance 0.21
Indeed, the recently developed antisense oligonucleotide, ATL 227446, effectively inhibited hepatic GH receptor expression and IGF-I production and decreased body weight gain in mice (Tachas et al 2006).
Gene_expression (expression) of GH receptor in body associated with body weight and htlv types i and ii
10) Confidence 0.53 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.20 Pain Relevance 0.15
In the human the GH antagonists are specific for the GH receptor and they do not bind to the prolactin receptor, in contrast to hGH itself (Goffin et al 1999).
Gene_expression (specific) of GH receptor associated with antagonist
11) Confidence 0.53 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.15 Pain Relevance 0.11
Unbound GH has a very short half-life of only a few minutes and bound GH (to GH-binding protein) of 16–18 minutes, so that treating GH excess with the native mutated GH is not practical.
Gene_expression (protein) of GH-binding
12) Confidence 0.53 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.15 Pain Relevance 0.10
GH and GH receptor structure
Gene_expression (structure) of GH receptor
13) Confidence 0.53 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.18 Pain Relevance 0.12
The GH receptor is synthesized and degraded continuously with a half-life of less than 60 minutes.
Gene_expression (synthesized) of GH receptor
14) Confidence 0.53 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.24 Pain Relevance 0.03
Theoretically, this could be accomplished by the construction of GH receptor antagonists and by RNA antisense techniques, thus preventing the synthesis of the GH receptor.
Gene_expression (synthesis) of GH receptor associated with antagonist
15) Confidence 0.53 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.29 Pain Relevance 0.16
In order to understand the mechanism underlying improved hepatic insulin sensitivity, we evaluated hepatic insulin sensitivity of HFD-fed GhrR KO mice with a pyruvate tolerance test (PTT), which measures the capacity of the liver to convert pyruvate to glucose, a process that would normally be inhibited by insulin.
Gene_expression (sensitivity) of GhrR in liver associated with tolerance
16) Confidence 0.49 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.14 Pain Relevance 0.05
Indeed our group has already shown that PTPH1-KO mice display higher GHR response in vivo and consequently a higher expression of its down-stream effector hormone, the IGF1 in liver and plasma [22].
Gene_expression (expression) of GHR in plasma associated with targeted disruption
17) Confidence 0.48 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.54 Pain Relevance 0.19
Activity levels of GPX in kidney tissues were 25% higher in GHR-KO compared with wild-type mice (Hauck et al. 2002).
Gene_expression (higher) of GHR-KO in kidney
18) Confidence 0.28 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.92 Pain Relevance 0
Minimal differences were noted in liver gene expression patterns between GHR-KO and normal animals.
Gene_expression (expression) of GHR-KO in liver
19) Confidence 0.28 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.52 Pain Relevance 0
Consistent with the normal embryonic development, the expression levels of genes involved in the somatotroph axis (Ghr, Igf1, Prlr), antioxidant defense (Gstt2, Hmox1, Ephx1), and oxidative metabolism (Gck, Gyg1, Cs, Ndufs8) did not differ significantly between wt and Csbm/m/Xpa?
Gene_expression (the expres) of Ghr in somatotroph
20) Confidence 0.25 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1698505 Disease Relevance 0.15 Pain Relevance 0

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