INT59909

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Context Info
Confidence 0.36
First Reported 1993
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.83
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (ATF7IP) nucleus (ATF7IP)
Anatomy Link Frequency
nerve 1
D-17 1
ATF7IP (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 6 97.42 Very High Very High Very High
Neuritis 1 96.72 Very High Very High Very High
antidepressant 58 96.42 Very High Very High Very High
noradrenaline 3 92.52 High High
Inflammation 1 72.32 Quite High
Serotonin 8 67.04 Quite High
depression 35 66.76 Quite High
Desipramine 16 59.24 Quite High
agonist 1 58.96 Quite High
antagonist 1 58.00 Quite High
Disease Link Frequency Relevance Heat
Depression 93 100.00 Very High Very High Very High
Spinal Cord Diseases 4 100.00 Very High Very High Very High
Recurrence 8 99.76 Very High Very High Very High
Anxiety Disorder 14 99.28 Very High Very High Very High
Uveitis 1 98.24 Very High Very High Very High
Neuritis 1 96.72 Very High Very High Very High
Leukemia 1 95.12 Very High Very High Very High
Disease 9 94.20 High High
Parkinson's Disease 1 77.36 Quite High
Paraparesis 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In those with lower-anxiety levels at screening, there were no associations between CRHR1 genotype and percent change in HAM-A or HAM-D.
HAM Neg (no) Binding (associations) of associated with anxiety disorder
1) Confidence 0.36 Published 2004 Journal Mol. Psychiatry Section Abstract Doc Link 15365580 Disease Relevance 0.85 Pain Relevance 0.39
SLC6A2 gene encodes a transporter, which regulates norepinephrine (noradrenaline) homeostasis and the reuptake of norepinephrine into presynaptic nerve terminals.24 SLC6A2 polymorphisms have been reported to be associated with depression25, 26 and response to antidepressants.27, 28 (v) SNPs or haplotypes in SLC6A3 (dopamine transporter or DAT1, located at 5p15.33), which encodes a transporter that is important in dopaminergic neurotransmission, were associated with risk for MDD or relative reduction of HAM-D21.
HAM Binding (associated) of in nerve associated with dopamine, antidepressant, depression and noradrenaline
2) Confidence 0.35 Published 2009 Journal Mol Psychiatry Section Body Doc Link PMC2834349 Disease Relevance 0.53 Pain Relevance 0.42
Recently, an ever increasing number of publications have described other disorders associated with HAM.
HAM Binding (associated) of associated with spinal cord diseases
3) Confidence 0.31 Published 1993 Journal Presse Med Section Abstract Doc Link 8415485 Disease Relevance 0.75 Pain Relevance 0.10
The primary efficacy measure was the proportion of patients achieving relapse based on a combination of HAM-D-17 score ?
HAM-D Binding (combination) of in D-17 associated with recurrence
4) Confidence 0.04 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656289 Disease Relevance 0.70 Pain Relevance 0

General Comments

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