INT5993

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Context Info
Confidence 0.70
First Reported 1980
Last Reported 2010
Negated 7
Speculated 8
Reported most in Abstract
Documents 122
Total Number 136
Disease Relevance 26.82
Pain Relevance 70.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nts)
Anatomy Link Frequency
neurons 10
nucleus 7
neuronal 5
nucleus accumbens 4
striatum 4
Nts (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 432 100.00 Very High Very High Very High
Enkephalin 178 100.00 Very High Very High Very High
medulla 157 100.00 Very High Very High Very High
Neuropeptide 151 100.00 Very High Very High Very High
substance P 105 100.00 Very High Very High Very High
gABA 93 100.00 Very High Very High Very High
Dorsal horn 68 100.00 Very High Very High Very High
Somatostatin 48 100.00 Very High Very High Very High
Cholecystokinin 39 100.00 Very High Very High Very High
Serotonin 32 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 12 100.00 Very High Very High Very High
Stress 13 99.98 Very High Very High Very High
Hyperalgesia 31 99.96 Very High Very High Very High
Lewy Body Disease 8 99.92 Very High Very High Very High
Hemorrhage 12 99.70 Very High Very High Very High
Pain 341 99.64 Very High Very High Very High
Convulsion 6 99.52 Very High Very High Very High
Nociception 310 99.30 Very High Very High Very High
Hypotension 13 99.24 Very High Very High Very High
Pressure Volume 2 Under Development 11 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because adenosine levels in the central nervous system increase during severe hemorrhage, we investigated to what extent these responses to hemorrhage may be due to activation of NTS adenosine receptors.
Positive_regulation (activation) of NTS in central nervous system associated with adenocard, cva and central nervous system
1) Confidence 0.70 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16751294 Disease Relevance 0.70 Pain Relevance 0.61
Taken together, the results are consistent with data indicating that activation of neurotensin receptors in the ventral mesencephalon stimulates dopamine cell firing and axonal dopamine release in limbic terminal fields and suggest that endogenous neurotensin is involved in the control of behavior motivated by positive reinforcement.
Positive_regulation (activation) of neurotensin in mesencephalon associated with dopamine
2) Confidence 0.70 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1319909 Disease Relevance 0 Pain Relevance 0.42
In comparison to values from lesioned, vehicle-treated controls, intermittent administration of SKF 38393 reduced somatostatin and neuropeptide Y (down 61% and 57%, respectively), increased neurotensin (up 105%) and dynorphin (up 184%) and had no effect on enkephalin; continuous SKF 38393 decreased neuropeptide Y by 39% but did not alter levels of the other peptides.
Positive_regulation (increased) of neurotensin associated with dynorphin, neuropeptide, somatostatin and enkephalin
3) Confidence 0.67 Published 1992 Journal Brain Res. Section Abstract Doc Link 1356580 Disease Relevance 0 Pain Relevance 1.15
In contrast, and consistent with previous reports, levels of neurotensin and enkephalin mRNAs were upregulated on the lesioned side of the striatum.
Positive_regulation (upregulated) of neurotensin in striatum associated with enkephalin
4) Confidence 0.67 Published 2002 Journal Brain Res. Section Abstract Doc Link 12126877 Disease Relevance 0 Pain Relevance 0.78
Conversely, intermittent quinpirole decreased somatostatin (down 35%) and neuropeptide Y (down 27%), increased neurotensin content by 79% and had no effect on enkephalin.
Positive_regulation (increased) of neurotensin associated with neuropeptide, somatostatin and enkephalin
5) Confidence 0.67 Published 1992 Journal Brain Res. Section Abstract Doc Link 1356580 Disease Relevance 0 Pain Relevance 1.08
Neurotensin levels were increased in the striatum, and [Leu5]enkephalin, and SP levels were reduced in the substantia nigra as a consequence of the lesion, while the levels of other peptides were unaltered.
Positive_regulation (increased) of Neurotensin in substantia nigra associated with substantia nigra, enkephalin and substance p
6) Confidence 0.67 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1385171 Disease Relevance 0 Pain Relevance 1.01
Our colocalization results show that the increases in neurotensin/neuromedin N and proenkephalin mRNAs after polyethylene glycol injection occur to a significant degree in cells that also contain corticotropin-releasing hormone mRNA.
Positive_regulation (increases) of neurotensin/neuromedin N
7) Confidence 0.67 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 7721997 Disease Relevance 0.07 Pain Relevance 0.04
A clear upregulation of neurotensin mRNA was seen after ether and, to a lesser extent, after immobilization stress, whereas after the two other stressors neurotensin mRNA was undetectable, as in control rats.
Positive_regulation (upregulation) of neurotensin associated with stress
8) Confidence 0.67 Published 1993 Journal Acta Endocrinol. Section Abstract Doc Link 8337918 Disease Relevance 0.17 Pain Relevance 0.18
Additionally, there are concomitant increases in cellular levels of both neurotensin/neuromedin N and proenkephalin mRNAs.
Positive_regulation (increases) of neurotensin/neuromedin N
9) Confidence 0.67 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 7721997 Disease Relevance 0.08 Pain Relevance 0.04
As the nociceptive stimuli became chronic, the early increases in neurotensin mRNA-containing neurons at the level of the middle third of the ventral PAG were diminished but remained above control levels, while increases in neurotensin mRNA began to occur in the midbrain tegmentum lateral to the PAG.
Positive_regulation (increases) of neurotensin mRNA in midbrain tegmentum associated with nociception, midbrain and central grey
10) Confidence 0.67 Published 1993 Journal Brain Res. Section Abstract Doc Link 8518953 Disease Relevance 1.45 Pain Relevance 0.70
However, the fact that METH caused greater increases in Nts transcript levels on the lesioned side suggests that both DA and 5-HT might be involved in regulating Nts transcript levels after injection of METH since methylenedioxymethamphetamine (MDMA) which causes 5-HT release can also increase Nts mRNA levels [50].
Positive_regulation (increase) of Nts associated with dopamine
11) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.38
The observations that the small dose of METH caused significant increases in Nts mRNA levels in the control animals (MC) that were of lesser magnitude than those induced by the drug on the lesioned striatum suggest that METH might enhance Nts gene expression in association with or via increased 5-HT release, given that METH caused increased 5-HIAA/5-HT ratios on the 6-OHDA lesioned side.
Positive_regulation (increases) of Nts in striatum
12) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.33
Phentolamine (2 mg/kg) increased significantly the ED50 of neurotensin and norepinephrine.
Positive_regulation (increased) of neurotensin
13) Confidence 0.60 Published 1984 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 6329497 Disease Relevance 0 Pain Relevance 0.13
In caudal dorsomedial medulla including NTS, tyrosine hydroxylase activity was increased in SHR compared to WKY, while there was no difference in either strain of L-aromatic amino acid decarboxylase activity. 5.
Positive_regulation (increased) of NTS in medulla associated with medulla and sprains and strains
14) Confidence 0.59 Published 1995 Journal Clin Exp Pharmacol Physiol Suppl Section Abstract Doc Link 9072420 Disease Relevance 0.69 Pain Relevance 0.25
Increases in Nts mRNA after METH have been reported previously and are thought to be related to stimulation of DA D1 receptors [49].
Positive_regulation (Increases) of Nts associated with dopamine
15) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.35
The neurotensin content of both the ipsilateral dorsal and ipsilateral ventral quadrants of the ventral rhizotomized cats was significantly increased.
Positive_regulation (increased) of neurotensin in ventral
16) Confidence 0.58 Published 1987 Journal Neuroscience Section Abstract Doc Link 2441314 Disease Relevance 0 Pain Relevance 0.74
Neurotensin levels in striatum were increased by administration of SKF 38393 and decreased by SCH 23390.
Positive_regulation (increased) of Neurotensin in striatum
17) Confidence 0.57 Published 1991 Journal Biochem. Pharmacol. Section Abstract Doc Link 1673340 Disease Relevance 0 Pain Relevance 1.33
Capsaicin treatment prevented the irradiation from affecting SP-induced contractile response or increasing neurotensin levels.
Positive_regulation (increasing) of neurotensin associated with qutenza and substance p
18) Confidence 0.55 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 12741457 Disease Relevance 0.14 Pain Relevance 0.90
The peptidase-resistant derivative of neurotensin, [D-Trp11]neurotensin, has been continuously infused intracerebroventricularly (75 ng/h) with an osmotic minipump for 10 days.
Positive_regulation (derivative) of neurotensin
19) Confidence 0.50 Published 1994 Journal Peptides Section Abstract Doc Link 8008636 Disease Relevance 0.16 Pain Relevance 0.29
The present results suggest that in rat proximal colon the inhibitory action of neurotensin is largely due to production of nitric oxide (NO), likely released from neural prejunctional sites.
Positive_regulation (action) of neurotensin in neural
20) Confidence 0.50 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9277430 Disease Relevance 0 Pain Relevance 0.14

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