INT5994

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Context Info
Confidence 0.18
First Reported 1988
Last Reported 1992
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.07
Pain Relevance 4.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ap1m2) vesicle-mediated transport (Ap1m2) Golgi apparatus (Ap1m2)
Anatomy Link Frequency
brain 1
Ap1m2 (Mus musculus)
Pain Link Frequency Relevance Heat
analgesia 15 99.68 Very High Very High Very High
Analgesic 9 99.60 Very High Very High Very High
opioid receptor 7 99.56 Very High Very High Very High
Morphine 13 98.86 Very High Very High Very High
antagonist 6 96.72 Very High Very High Very High
Opioid 4 96.28 Very High Very High Very High
MU agonist 2 92.64 High High
Potency 7 91.88 High High
intrathecal 1 90.24 High High
narcan 1 81.24 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 1 65.12 Quite High
Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In selective analgesic assays, nefazodone enhanced mu 1, mu 2 and delta analgesia, but not kappa 1 or kappa 3 analgesia.
Neg (not) Positive_regulation (enhanced) of mu 2 associated with analgesic and analgesia
1) Confidence 0.18 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1319913 Disease Relevance 0 Pain Relevance 1.86
In the present study, 8 day treatment with naltrexone blocked morphine and DADLE analgesia for the entire treatment period and increased mu 1, mu 2 and delta opioid receptor binding sites in mouse brain. mu 1 and mu 2 binding were increased by 81 and 67%, respectively, while delta binding was increased by 31%.
Positive_regulation (increased) of mu 2 in brain associated with opioid receptor, analgesia and morphine
2) Confidence 0.12 Published 1988 Journal Life Sci. Section Abstract Doc Link 2845219 Disease Relevance 0 Pain Relevance 1.14
Thus, TRIMU-5 analgesia appeared to be mediated spinally through mu 2 receptors.
Positive_regulation (mediated) of mu 2 associated with analgesia
3) Confidence 0.01 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1327812 Disease Relevance 0.07 Pain Relevance 1.68

General Comments

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