INT59945

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Context Info
Confidence 0.00
First Reported 1993
Last Reported 1993
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (C2) extracellular space (C2) extracellular region (C2)
Anatomy Link Frequency
nerve 1
C2 (Homo sapiens)
Srms (Rattus norvegicus)
Pain Link Frequency Relevance Heat
local anesthetic 9 96.80 Very High Very High Very High
lidocaine 1 81.12 Quite High
tetrodotoxin 1 45.48 Quite Low
sodium channel 1 44.92 Quite Low
Sciatic nerve 1 25.24 Quite Low
Action potential 1 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, slight differences in the molecular structure of 3 degrees-amine LAs with similar pKa values resulted in significantly different potentiations (e.g., procaine, PF = 3.9; 2-chloroprocaine, PF = 8.7), suggesting that the HCO3- or CO2 molecules interact specifically with the LA molecule or with LA binding sites in the nerve membrane.
CO2 Binding (interact) of sites in nerve associated with local anesthetic
1) Confidence 0.00 Published 1993 Journal Anesth. Analg. Section Abstract Doc Link 8418714 Disease Relevance 0 Pain Relevance 0.53

General Comments

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