INT59956

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Context Info
Confidence 0.49
First Reported 1993
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.99
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SCARB1) small molecule metabolic process (SCARB1) cell adhesion (SCARB1)
plasma membrane (SCARB1) lipid metabolic process (SCARB1) cytoplasm (SCARB1)
Anatomy Link Frequency
Macrophage 1
SCARB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
backache 1 87.96 High High
drug abuse 57 59.92 Quite High
cocaine 28 50.00 Quite Low
cannabis 16 50.00 Quite Low
Angina 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
Opioid 3 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 23 98.56 Very High Very High Very High
Atherosclerosis 39 97.40 Very High Very High Very High
Low Back Pain 1 87.96 High High
Atherosclerotic Plaque 25 86.16 High High
Osteoporosis 1 80.96 Quite High
Drug Dependence 58 59.92 Quite High
Hypoxia 14 38.36 Quite Low
Phencyclidine Abuse 4 23.00 Low Low
Cardiovascular Disease 10 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Macrophage SR-BI expression levels were not correlated to serum HDL cholesterol levels in the macrophage INTERGENE subjects (data not shown).


Positive_regulation (Macrophage) of SR-BI in Macrophage associated with disorder of lipid metabolism
1) Confidence 0.49 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.66 Pain Relevance 0
Most transcripts regulating cholesterol biosynthesis (FDFT1, PRKAB1) and trafficking (SCARB1, APOL2) were increased, but transcription of the secreted apolipoprotein APOL1 and a peroxisomal protein (ECHDC1) involved in beta-oxidation of cholesterol were decreased.
Positive_regulation (increased) of SCARB1 associated with disorder of lipid metabolism
2) Confidence 0.32 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.16 Pain Relevance 0.03
Group 2 had on average a greater increase in bone mass over the 4 years; mean increases in CaBI, (+/- SD) were 0.09 +/- 0.09 and 0.05 +/- 0.10 for groups 2 and 1 respectively.
Positive_regulation (increases) of CaBI
3) Confidence 0.27 Published 1993 Journal Osteoporos Int Section Abstract Doc Link 8422510 Disease Relevance 0.17 Pain Relevance 0.09

General Comments

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