INT59964

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Context Info
Confidence 0.59
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.25
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Pcsk4)
Anatomy Link Frequency
testis 2
A431 1
T-cells 1
Pcsk4 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 4 100.00 Very High Very High Very High
Inflammation 4 69.44 Quite High
topical agent 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Squamous Cell Carcinoma 4 99.62 Very High Very High Very High
Lymphatic System Cancer 22 97.36 Very High Very High Very High
Malignant Neoplastic Disease 34 96.44 Very High Very High Very High
Necrosis 6 94.24 High High
Death 6 92.44 High High
Cancer 14 91.92 High High
Apoptosis 60 90.12 High High
Wrinkles 10 77.12 Quite High
INFLAMMATION 4 69.44 Quite High
Immunotherapy Of Cancer 2 63.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By in situ hybridization analysis, we show here the localization of furin and PC4, which are both members of a growing family of endoproteases structurally related to the yeast precursor processing protease Kex2, within mouse testis.
Localization (localization) of PC4 in testis
1) Confidence 0.59 Published 1993 Journal FEBS Lett. Section Abstract Doc Link 8422932 Disease Relevance 0 Pain Relevance 0
Localization of Kex2-like processing endoproteases, furin and PC4, within mouse testis by in situ hybridization.
Localization (Localization) of PC4 in testis associated with enkephalin
2) Confidence 0.51 Published 1993 Journal FEBS Lett. Section Title Doc Link 8422932 Disease Relevance 0 Pain Relevance 0.20
Our previous findings indicated that Jurkat cells were more sensitive to Pc 4-PDT-induced killing than epidermoid carcinoma A431 cells, while uptake of Pc 4 by both cell populations was shown to be similar in low to moderate doses (0.1?
Localization (uptake) of Pc 4 in A431 associated with squamous cell carcinoma
3) Confidence 0.11 Published 2010 Journal Advances in Hematology Section Body Doc Link PMC3004392 Disease Relevance 1.23 Pain Relevance 0
T-cells over normal bystander cells was observed in vitro, which suggests that Pc 4-PDT can potentially be utilized as a target-specific anticancer therapy for malignancies such as CTCL.
Localization (utilized) of Pc 4 in T-cells associated with lymphatic system cancer
4) Confidence 0.11 Published 2010 Journal Advances in Hematology Section Body Doc Link PMC3004392 Disease Relevance 1.02 Pain Relevance 0.03

General Comments

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