INT59969

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Context Info
Confidence 0.67
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 5.07
Pain Relevance 5.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Htr1a) plasma membrane (Htr1a) signal transducer activity (Htr1a)
Anatomy Link Frequency
neurons 1
immune system 1
Htr1a (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 35 100.00 Very High Very High Very High
agonist 26 100.00 Very High Very High Very High
5HT 22 99.90 Very High Very High Very High
Calcitonin gene-related peptide 14 99.74 Very High Very High Very High
Serotonin 468 99.62 Very High Very High Very High
qutenza 7 99.60 Very High Very High Very High
antagonist 24 99.32 Very High Very High Very High
Triptan 28 98.00 Very High Very High Very High
fluoxetine 34 97.24 Very High Very High Very High
adenocard 10 97.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Serotonin Syndrome 2 99.80 Very High Very High Very High
Apoptosis 25 99.40 Very High Very High Very High
Repression 4 98.96 Very High Very High Very High
Endometriosis (extended) 130 98.56 Very High Very High Very High
Targeted Disruption 17 98.00 Very High Very High Very High
Cluster Headache 6 93.36 High High
Obesity 20 92.96 High High
Fibrosarcoma 1 92.44 High High
Convulsion 1 91.24 High High
Epilepsy 3 90.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This theoretical risk seems however to be unwarranted, since the pathophysiology of the serotonin syndrome involves activation of 5-HT1A and 5-HT2A receptors, not the receptors to which triptans are agonist.60 Several reports also point to fact that this does not happen in clinical practice.
Positive_regulation (activation) of 5-HT1A associated with agonist, triptan and serotonin
1) Confidence 0.67 Published 2010 Journal Drug design, development and therapy Section Body Doc Link PMC2846149 Disease Relevance 0.99 Pain Relevance 1.30
Indeed, the 5-HT neurons play a crucial role in respiratory function and dysfunction [14]: they are intrinsically chemosensitive [12], synaptically contact the respiratory neurons [15] and exert a facilitatory modulation on the RRG via a release of endogenous 5HT and activation of 5-HT1A receptors [16], [36].
Positive_regulation (activation) of 5-HT1A in neurons associated with 5ht
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.34 Pain Relevance 0.38
Blunted 5-HT1A-receptor agonist-induced corticotropin and cortisol responses after long-term ipsapirone and fluoxetine administration to healthy subjects.
Positive_regulation (agonist-induced) of 5-HT1A-receptor associated with agonist and fluoxetine
3) Confidence 0.07 Published 1998 Journal Clin. Pharmacol. Ther. Section Title Doc Link 9585797 Disease Relevance 0 Pain Relevance 0.23
activation results in an increase in 5HT1A receptors via nuclear factor kappa B (NFkB) [26].
Positive_regulation (increase) of 5HT1A
4) Confidence 0.01 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 0 Pain Relevance 0.53
In contrast, 5HT1A activation (which occurs preferentially after menopause) decreases apoptotic signaling via caspase-3 suppression [38].
Positive_regulation (activation) of 5HT1A associated with endometriosis (extended) and apoptosis
5) Confidence 0.01 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 1.78 Pain Relevance 0.13
Increased activation of 5HT1A in the immune system results in greater mitotic potential via cyclic adenosine monophosphate (cAMP) and extra cellular response kinase (ERK) [37-40].
Positive_regulation (activation) of 5HT1A in immune system associated with adenocard
6) Confidence 0.01 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 0 Pain Relevance 0.49
Increased E2 in the presence of progesterone increases activation of 5HT2A receptors, while increased E2 in the absence of progesterone increases activation of 5HT1A receptors.
Positive_regulation (activation) of 5HT1A
7) Confidence 0.01 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 1.13 Pain Relevance 0.11
Repression of the calcitonin gene-related peptide promoter by 5-HT1 receptor activation.
Positive_regulation (activation) of 5-HT1 receptor associated with repression and calcitonin gene-related peptide
8) Confidence 0.01 Published 1997 Journal J. Neurosci. Section Title Doc Link 9391009 Disease Relevance 0.35 Pain Relevance 0.56
These results demonstrate that activation of the endogenous 5-HT1 receptor is coupled to calcium signaling pathways and leads to inhibition of CGRP gene transcription.
Positive_regulation (activation) of 5-HT1 receptor associated with calcitonin gene-related peptide
9) Confidence 0.01 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9391009 Disease Relevance 0.28 Pain Relevance 0.48
The EC(50) of capsaicin and OLDA on (45)Ca accumulation of rTRPV1-expressing HT5-1 cells was 36 nM and 1.8 microM, respectively.
Positive_regulation (accumulation) of HT5-1 associated with qutenza
10) Confidence 0.01 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15135917 Disease Relevance 0.19 Pain Relevance 0.34
Using 5-MeOT as the prototype agonist, cyanopindolol blocked contraction with an antagonist dissociation constant lower than expected for 5-HT1-receptor blockade and ICS 205-930 (10 microM) did not affect 5-MeOT-induced contraction.
Positive_regulation (expected) of 5-HT1-receptor associated with antagonist and agonist
11) Confidence 0.00 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8423526 Disease Relevance 0 Pain Relevance 0.60
Following 5HT2A activation of PKC, 5HT1A receptors become unable to reduce serotonin production through negative feedback, and serotonin concentrations increase [32-34] E2 compounds this effect by directly inhibiting 5HT1A function [35,36].
Positive_regulation (activation) of 5HT1A associated with kinase c and serotonin
12) Confidence 0.00 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 0 Pain Relevance 0.57

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