INT59983

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Context Info
Confidence 0.45
First Reported 1993
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 10.69
Pain Relevance 5.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (BDKRB1) plasma membrane (BDKRB1) signal transducer activity (BDKRB1)
Anatomy Link Frequency
fibroblasts 2
skin 1
BDKRB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 519 100.00 Very High Very High Very High
B1 receptor 25 100.00 Very High Very High Very High
antagonist 9 99.96 Very High Very High Very High
Pain 42 99.84 Very High Very High Very High
Perioperative pain 2 99.56 Very High Very High Very High
vincristine 4 99.36 Very High Very High Very High
Inflammation 144 98.76 Very High Very High Very High
Hyperalgesia 7 97.76 Very High Very High Very High
nociceptor 4 96.76 Very High Very High Very High
diabetic neuropathy 3 95.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 1158 99.84 Very High Very High Very High
Pain 44 99.84 Very High Very High Very High
Post Operative Pain 2 99.56 Very High Very High Very High
INFLAMMATION 145 98.76 Very High Very High Very High
Down Syndrome 96 97.80 Very High Very High Very High
Death 6 97.80 Very High Very High Very High
Hyperalgesia 8 97.76 Very High Very High Very High
Diabetic Neuropathy 3 95.52 Very High Very High Very High
Injury 50 95.12 Very High Very High Very High
Head Trauma 12 94.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We hypothesized that kinins autoregulate B2R and B1R expression in favor of B1R.
Regulation (autoregulate) of B1R
1) Confidence 0.45 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10419551 Disease Relevance 0.28 Pain Relevance 0.77
The similar correlation between B1 expression and pain intensity points to the participation of B1 receptor in pain processes at this early time point (3 hours) in contrast to earlier reports [16] confining the contribution of B1 receptors to nociception to later time points.
Regulation (participation) of B1 receptor associated with nociception, pain and b1 receptor
2) Confidence 0.26 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 1.03 Pain Relevance 1.19
The inducible kinin B1 receptor is emerging as an attractive therapeutic target for the treatment of pain and inflammation.
Regulation (target) of B1 receptor associated with pain, inflammation and b1 receptor
3) Confidence 0.23 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16407468 Disease Relevance 0.20 Pain Relevance 0.32
The latter second messenger is also a known downstream target of the BKB2R [52].
Regulation (target) of BKB2R
4) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0.52 Pain Relevance 0.03
Effect of bradykinin receptor antagonists on vincristine- and streptozotocin-induced hyperalgesia in a rat model of chemotherapy-induced and diabetic neuropathy.
Regulation (Effect) of bradykinin receptor associated with vincristine, hyperalgesia, diabetic neuropathy, antagonist and bradykinin
5) Confidence 0.06 Published 2008 Journal Pharmacology Section Title Doc Link 17989505 Disease Relevance 0.52 Pain Relevance 0.77
In a PKC-dependent process the BK B2 subtype receptor (BKB2R) is modulated to forms that reflect activity of a Tyr phosphorylation pathway [13].
Regulation (modulated) of BK B2 subtype receptor associated with bradykinin
6) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 1.88 Pain Relevance 0.47
In a PKC-dependent process the BK B2 subtype receptor (BKB2R) is modulated to forms that reflect activity of a Tyr phosphorylation pathway [13].
Regulation (modulated) of BKB2R associated with bradykinin
7) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 1.81 Pain Relevance 0.47
PS-1 M146L AD fibroblasts display prolonged BKB2R modulation
Regulation (modulation) of BKB2R in fibroblasts associated with disease
8) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 1.43 Pain Relevance 0.12
We previously found that activation of PKC by 25 nM phorbol myristate acetate (PMA) or by treatment with 250 nM BK prompted modulation of the BKB2R in AD skin fibroblasts (Table 1), detected by monoclonal anti-BKB2R antibodies recognizing the modulated receptors that reflect enhanced activity of a Tyr phosphorylation pathway in the AD cells [8], [12].
Regulation (modulation) of BKB2R in skin associated with disease and bradykinin
9) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 1.39 Pain Relevance 0.12
The altered PKC-dependent signal transduction pathway we defined in skin fibroblasts from AD patients, yielding BKB2R modulated by phosphorylation [8], [13], [14], is discernible in Trisomy 21 fibroblasts decades before the characteristic age of onset of symptomatic AD.
Regulation (modulated) of BKB2R in fibroblasts associated with down syndrome and disease
10) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 1.02 Pain Relevance 0.08
RESULTS: The nitric oxide synthase (NOS) inhibitors (L-NNA, 20 mg/kg; L-NMMA, 30 mg/kg and AGUA, 50 mg/kg; i.p.), the SP antagonists (sendide and L-732,138, 100 microg/kg; i.v.) and the CGRP antagonist (hCGRP8-37, 100 microg/kg; i.v.) significantly attenuated the hyperalgesic activity and also reversed the potentiating effect of the BKB1- R agonist, DBK on diabetic hyperalgesia in STZ-mice.
Regulation (effect) of BKB1
11) Confidence 0.00 Published 2004 Journal Inflamm. Res. Section Body Doc Link 15654512 Disease Relevance 0.14 Pain Relevance 0
Effect of flurbiprofen on tissue levels of immunoreactive bradykinin and acute postoperative pain.
Regulation (Effect) of immunoreactive bradykinin associated with perioperative pain and bradykinin
12) Confidence 0.00 Published 1993 Journal J. Oral Maxillofac. Surg. Section Title Doc Link 8426248 Disease Relevance 0.25 Pain Relevance 0.47
This study evaluates whether preoperative administration of flurbiprofen alters the levels of immunoreactive bradykinin (iBK) peripherally released into inflamed tissue.
Spec (whether) Regulation (alters) of immunoreactive bradykinin associated with bradykinin
13) Confidence 0.00 Published 1993 Journal J. Oral Maxillofac. Surg. Section Abstract Doc Link 8426248 Disease Relevance 0.21 Pain Relevance 0.30

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