INT59984

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Context Info
Confidence 0.45
First Reported 1993
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.08
Pain Relevance 3.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (BDKRB1) plasma membrane (BDKRB1) signal transducer activity (BDKRB1)
BDKRB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 115 100.00 Very High Very High Very High
acular 42 99.24 Very High Very High Very High
Pain 63 99.04 Very High Very High Very High
Inflammation 40 93.84 High High
Analgesic 4 92.40 High High
agonist 9 75.00 Quite High
Perioperative pain 1 75.00 Quite High
antagonist 3 62.64 Quite High
B1 receptor 34 52.72 Quite High
Acute pain 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Pain 67 99.04 Very High Very High Very High
Injury 64 98.84 Very High Very High Very High
INFLAMMATION 42 93.84 High High
Post Operative Pain 1 75.00 Quite High
Inflammatory Pain 26 12.32 Low Low
Osteoarthritis 6 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 6 5.00 Very Low Very Low Very Low
Hyperalgesia 4 5.00 Very Low Very Low Very Low
Frailty 4 5.00 Very Low Very Low Very Low
Nociception 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We hypothesized that kinins autoregulate B2R and B1R expression in favor of B1R.
Regulation (autoregulate) of Gene_expression (expression) of B1R
1) Confidence 0.45 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10419551 Disease Relevance 0.28 Pain Relevance 0.78
The correlation between the sum of pain intensity scores as measured by VAS and the up-regulation of gene expression of BDKRB1 and BDKRB2 following tissue injury was examined using Pearson's correlation coefficients (Fig. 2 b-e).
Regulation (regulation) of Gene_expression (expression) of BDKRB1 associated with pain and injury
2) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.87 Pain Relevance 1.27
Ketorolac treatment did not have a significant effect on the gene expression of either BDKRB1 (p = 0.71; unpaired t-test) or BDKRB2 (p = 0.73; unpaired t-test).

3.

Regulation (effect) of Gene_expression (expression) of BDKRB1 associated with acular
3) Confidence 0.37 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.73 Pain Relevance 1.13
This study evaluates whether preoperative administration of flurbiprofen alters the levels of immunoreactive bradykinin (iBK) peripherally released into inflamed tissue.
Spec (whether) Regulation (alters) of Gene_expression (levels) of immunoreactive bradykinin associated with bradykinin
4) Confidence 0.00 Published 1993 Journal J. Oral Maxillofac. Surg. Section Abstract Doc Link 8426248 Disease Relevance 0.21 Pain Relevance 0.30

General Comments

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