INT59986

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Context Info
Confidence 0.61
First Reported 1993
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.69
Pain Relevance 3.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (BDKRB1) plasma membrane (BDKRB1) signal transducer activity (BDKRB1)
Anatomy Link Frequency
mononuclear cells 2
bowel 1
HEK 1
BDKRB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 21 100.00 Very High Very High Very High
B1 receptor 9 100.00 Very High Very High Very High
cytokine 5 100.00 Very High Very High Very High
agonist 5 99.82 Very High Very High Very High
Analgesic 6 99.02 Very High Very High Very High
Inflammation 10 98.88 Very High Very High Very High
Pain 4 95.44 Very High Very High Very High
b2 receptor 8 92.08 High High
antagonist 14 91.12 High High
Potency 2 87.68 High High
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 11 98.88 Very High Very High Very High
INFLAMMATION 8 96.64 Very High Very High Very High
Pain 4 95.44 Very High Very High Very High
Increased Venous Pressure Under Development 1 95.20 Very High Very High Very High
Disease 4 76.16 Quite High
Post Operative Pain 1 75.00 Quite High
Granuloma 1 69.28 Quite High
Inflammatory Pain 1 53.88 Quite High
Sepsis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compound 11 (1 nM) inhibited both the phosphorylation of the extracellular signal-regulated kinase1/2 mitogen-activated protein kinases induced by Lys-des-Arg9-BK in serum-starved rabbit aortic smooth muscle cells and the agonist-induced translocation of the fusion protein B1R-yellow fluorescent protein expressed in human embryonic kidney (HEK) 293 cells.
Localization (translocation) of B1R in HEK associated with b1 receptor and agonist
1) Confidence 0.61 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15277582 Disease Relevance 0.11 Pain Relevance 0.67
Immunolocalization and expression of kinin B1R and B2R receptors in human inflammatory bowel disease.
Localization (Immunolocalization) of kinin B1R in bowel associated with inflammation
2) Confidence 0.53 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 15805101 Disease Relevance 1.37 Pain Relevance 0.67
Furthermore, this analog shows analgesic activity, blocks in a dose-dependent manner the bradykinin-induced Ca2+ release from macrophages and inhibits at a concentration of 10(-13) M the bradykinin-induced cytokine release from mononuclear cells.
Localization (release) of bradykinin-induced in mononuclear cells associated with analgesic, bradykinin and cytokine
3) Confidence 0.08 Published 1996 Journal Immunopharmacology Section Abstract Doc Link 8856118 Disease Relevance 0 Pain Relevance 0.90
Furthermore, this analog shows analgesic activity, blocks in a dose-dependent manner the bradykinin-induced Ca2+ release from macrophages and inhibits at a concentration of 10(-13) M the bradykinin-induced cytokine release from mononuclear cells.
Localization (release) of bradykinin-induced in mononuclear cells associated with analgesic, bradykinin and cytokine
4) Confidence 0.08 Published 1996 Journal Immunopharmacology Section Abstract Doc Link 8856118 Disease Relevance 0 Pain Relevance 0.91
This study evaluates whether preoperative administration of flurbiprofen alters the levels of immunoreactive bradykinin (iBK) peripherally released into inflamed tissue.
Localization (released) of immunoreactive bradykinin associated with bradykinin
5) Confidence 0.00 Published 1993 Journal J. Oral Maxillofac. Surg. Section Abstract Doc Link 8426248 Disease Relevance 0.21 Pain Relevance 0.30

General Comments

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