INT59987

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Context Info
Confidence 0.77
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 25
Total Number 26
Disease Relevance 11.95
Pain Relevance 15.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (BDKRB1) plasma membrane (BDKRB1) signal transducer activity (BDKRB1)
Anatomy Link Frequency
HEK 3
MG-63 2
HOS 2
nerves 1
bowel 1
BDKRB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 633 100.00 Very High Very High Very High
B1 receptor 194 100.00 Very High Very High Very High
antagonist 44 100.00 Very High Very High Very High
Cannabinoid 1 99.92 Very High Very High Very High
b2 receptor 111 99.80 Very High Very High Very High
acular 189 99.72 Very High Very High Very High
orphanin 1 99.66 Very High Very High Very High
Pain 284 99.34 Very High Very High Very High
Opioid 3 99.28 Very High Very High Very High
Inflammation 200 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 291 99.48 Very High Very High Very High
Osteogenic Sarcomas 4 99.44 Very High Very High Very High
Pain 302 99.34 Very High Very High Very High
INFLAMMATION 209 99.16 Very High Very High Very High
Inflammatory Bowel Disease 11 98.88 Very High Very High Very High
Increased Venous Pressure Under Development 8 97.64 Very High Very High Very High
Hyperalgesia 19 96.76 Very High Very High Very High
Drug Dependence 1 95.96 Very High Very High Very High
Constipation 1 95.00 High High
Vomiting 1 94.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compound 11 (2-[(2R)-1-[(3,4-dichlorophenyl) sulfonyl]-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl]-N-[2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl]acetamide) is a high-affinity nonpeptide antagonist for the human B1R, but it is potent at the rabbit B1R as well: its Ki value for the inhibition of [3H]Lys-des-Arg9-BK (bradykinin) binding to a novel myc-labeled rabbit B1R expressed in COS-1 is 22 pM.
Gene_expression (expressed) of B1R associated with b1 receptor, antagonist and bradykinin
1) Confidence 0.77 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15277582 Disease Relevance 0.17 Pain Relevance 0.57
We hypothesized that kinins autoregulate B2R and B1R expression in favor of B1R.
Gene_expression (expression) of B1R
2) Confidence 0.77 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10419551 Disease Relevance 0.27 Pain Relevance 0.77
The correlation between the sum of pain intensity scores as measured by VAS and the up-regulation of gene expression of BDKRB1 and BDKRB2 following tissue injury was examined using Pearson's correlation coefficients (Fig. 2 b-e).
Gene_expression (expression) of BDKRB1 associated with pain and injury
3) Confidence 0.74 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.86 Pain Relevance 1.26
The correlation we show here between the gene expression of B2 and B1 receptor supports this mechanism in the present clinical model of tissue injury.
Gene_expression (expression) of B1 receptor associated with b1 receptor and injury
4) Confidence 0.74 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.85 Pain Relevance 0.76
This early expression of B1 receptor [30] or even its constitutive expression [31] has been shown earlier in some experimental studies.
Gene_expression (expression) of B1 receptor associated with b1 receptor
5) Confidence 0.74 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.81 Pain Relevance 0.70
The B1 receptor expression is up-regulated following tissue injury and inflammation (hyperemia, exudation, hyperalgesia, etc.).
Gene_expression (expression) of B1 receptor associated with hyperalgesia, inflammation, b1 receptor, injury and increased venous pressure under development
6) Confidence 0.74 Published 1996 Journal Genomics Section Abstract Doc Link 8660997 Disease Relevance 0.39 Pain Relevance 0.42
Moreover, B2 receptors (B2R), which mediate the action of BK and KD, participates in the acute stage of the inflammatory and pain response, whereas B1 receptors (B1R), through which desArg(9)BK and desArg(10)KD act, partake in the chronic stage.
Gene_expression (partake) of B1R associated with pain, inflammation and bradykinin
7) Confidence 0.67 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10419551 Disease Relevance 0.29 Pain Relevance 0.75
Ketorolac treatment did not have a significant effect on the gene expression of either BDKRB1 (p = 0.71; unpaired t-test) or BDKRB2 (p = 0.73; unpaired t-test).

3.

Gene_expression (expression) of BDKRB1 associated with acular
8) Confidence 0.64 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.73 Pain Relevance 1.13
Using two human embryonic kidney (HEK) 293 cell lines stably expressing rabbit B1 receptors tagged with the yellow fluorescent protein at the C terminus (B1R-YFP) or the N-terminal myc epitope (myc-B1R), we showed that receptors are mainly retained in a perinuclear compartment and detectable as low-glycosylated species under control conditions.
Gene_expression (expressing) of B1R-YFP in HEK
9) Confidence 0.64 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16407468 Disease Relevance 0.18 Pain Relevance 0.38
This early expression of B1 receptor [30] or even its constitutive expression [31] has been shown earlier in some experimental studies.
Gene_expression (expression) of B1 receptor associated with b1 receptor
10) Confidence 0.64 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.82 Pain Relevance 0.71
Compound 11 does not importantly modify the expression of myc-B1R over 24 h in HEK 293 cells (no detectable action as "pharmacological chaperone").
Gene_expression (expression) of B1R in HEK associated with b1 receptor
11) Confidence 0.60 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15277582 Disease Relevance 0 Pain Relevance 0.60
BK receptors B1 (B1R) and B2 (B2R) were expressed in SaM-1 and osteosarcoma (SaOS-2, HOS, and MG-63) cells.
Gene_expression (expressed) of BK receptors B1 in MG-63 associated with osteogenic sarcomas and bradykinin
12) Confidence 0.58 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15345332 Disease Relevance 0.25 Pain Relevance 0.49
BK receptors B1 (B1R) and B2 (B2R) were expressed in SaM-1 and osteosarcoma (SaOS-2, HOS, and MG-63) cells.
Gene_expression (expressed) of B1R in MG-63 associated with osteogenic sarcomas and bradykinin
13) Confidence 0.58 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15345332 Disease Relevance 0.25 Pain Relevance 0.49
Correlation between the gene expression of BDKRB1, BDKRB2, TRPV1 and NF?
Gene_expression (expression) of BDKRB1
14) Confidence 0.57 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.33 Pain Relevance 0.40
Interestingly, the change in gene expression of TRPV1 was correlated to the change in gene expression of B1 receptor but not B2 receptor.


Gene_expression (expression) of B1 receptor associated with b1 receptor and b2 receptor
15) Confidence 0.57 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2834653 Disease Relevance 0.89 Pain Relevance 0.72
Effect of tissue injury and ketorolac treatment on BDKRB1 and BDKRB2 gene expression at the site of tissue injury
Gene_expression (expression) of BDKRB1 associated with injury and acular
16) Confidence 0.57 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.62 Pain Relevance 0.73
Immunolocalization and expression of kinin B1R and B2R receptors in human inflammatory bowel disease.
Gene_expression (expression) of kinin B1R in bowel associated with inflammation
17) Confidence 0.55 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 15805101 Disease Relevance 1.37 Pain Relevance 0.67
Compound 11 (1 nM) inhibited both the phosphorylation of the extracellular signal-regulated kinase1/2 mitogen-activated protein kinases induced by Lys-des-Arg9-BK in serum-starved rabbit aortic smooth muscle cells and the agonist-induced translocation of the fusion protein B1R-yellow fluorescent protein expressed in human embryonic kidney (HEK) 293 cells.
Gene_expression (expressed) of B1R in HEK associated with b1 receptor and agonist
18) Confidence 0.52 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15277582 Disease Relevance 0.10 Pain Relevance 0.68
The gene expression of BDKRB1 and BDKRB2 were significantly correlated (r = 0.52; p = 0.004; n = 30; Fig. 3a).
Gene_expression (expression) of BDKRB1
19) Confidence 0.50 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.14 Pain Relevance 0.24
In 1.75-day-old cultures, the marked increase in the proportion of cells with positive bradykinin binding is due to a de novo expression of the B1 receptor subtype and an up-regulation of the B2 receptor subtype.
Gene_expression (expression) of B1 receptor associated with b1 receptor, b2 receptor and bradykinin
20) Confidence 0.23 Published 1996 Journal Neuroscience Section Abstract Doc Link 8938754 Disease Relevance 0.25 Pain Relevance 0.92

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