INT60040

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Context Info
Confidence 0.43
First Reported 1993
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.64
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ace) peptidase activity (Ace) extracellular space (Ace)
extracellular region (Ace) plasma membrane (Ace)
Anatomy Link Frequency
blood 4
smooth muscle cell 2
Ace (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 6 99.96 Very High Very High Very High
Angina 2 98.76 Very High Very High Very High
Calcium channel 3 95.28 Very High Very High Very High
antagonist 16 88.92 High High
fibrosis 38 82.28 Quite High
Kinase C 2 20.52 Low Low
Inflammation 12 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Dismenorea 4 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 6 100.00 Very High Very High Very High
Coronary Artery Disease 35 99.36 Very High Very High Very High
Duchenne Muscular Dystrophy 20 99.34 Very High Very High Very High
Muscular Dystrophy 140 99.18 Very High Very High Very High
Cv General 3 Under Development 1 98.76 Very High Very High Very High
Myocardial Infarction 24 95.68 Very High Very High Very High
Cardiovascular Disease 7 95.08 Very High Very High Very High
Cardiomyopathy 63 90.68 High High
Atherosclerosis 17 82.64 Quite High
Hypotension 1 82.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ACE inhibitors may reduce tolerance to nitrates, reduce angina in some but not all studies, and limit smooth muscle cell proliferation (and perhaps restenosis) induced by experimental balloon angioplasty.
Negative_regulation (reduce) of Negative_regulation (inhibitors) of ACE in smooth muscle cell associated with angina, cardiovascular disease and tolerance
1) Confidence 0.43 Published 1993 Journal Clin Cardiol Section Abstract Doc Link 8435934 Disease Relevance 0.97 Pain Relevance 0.15
Therefore, direct renin inhibitors have the potential of more comprehensive suppression of the RAAS than ACE inhibitors and ARBs.
Negative_regulation (suppression) of Negative_regulation (inhibitors) of ACE
2) Confidence 0.40 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.12 Pain Relevance 0.08
In addition to blockade of the RAS system via ACE inhibition, direct blockade of Ang II receptors has proven to be beneficial in patients with systolic dysfunction and myocardial infarction (Pfeffer, McMurray et al 2003; Pfeffer, Swedberg et al 2003).
Negative_regulation (blockade) of Negative_regulation (inhibition) of ACE associated with myocardial infarction
3) Confidence 0.37 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.64 Pain Relevance 0
mg/kg) decreased blood pressure in SHRs for at least 24 hours, and intravenous injection of the ACE inhibitor captopril (2?
Negative_regulation (injection) of Negative_regulation (inhibitor) of ACE in blood associated with pressure volume 2 under development
4) Confidence 0.15 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.33 Pain Relevance 0
mg/kg) decreased blood pressure in SHRs for at least 24 hours, and intravenous injection of the ACE inhibitor captopril (2?
Negative_regulation (decreased) of Negative_regulation (injection) of ACE in blood associated with pressure volume 2 under development
5) Confidence 0.15 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.33 Pain Relevance 0
An uncontrolled retrospective study showed that echocardiographic parameters, including left ventricular ejection fraction, fractional shortening, and sphericity index, in DMD and BMD patients improved 3 years after administration of either ACE inhibitors alone or the combination of both ACE-inhibitors and ?
Negative_regulation (administration) of Negative_regulation (inhibitors) of ACE associated with duchenne muscular dystrophy and muscular dystrophy
6) Confidence 0.14 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024556 Disease Relevance 1.25 Pain Relevance 0.15

General Comments

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