INT60044

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 38
Total Number 38
Disease Relevance 4.98
Pain Relevance 14.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Syn1) ligase activity (Syn1)
Anatomy Link Frequency
neuronal 4
brain 3
neurons 3
hippocampus 2
dentate gyrus 1
Syn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 68 99.72 Very High Very High Very High
Hippocampus 13 99.68 Very High Very High Very High
agonist 11 99.44 Very High Very High Very High
monoamine 3 99.44 Very High Very High Very High
Serotonin 10 99.32 Very High Very High Very High
opiate 32 98.86 Very High Very High Very High
cerebral cortex 6 98.80 Very High Very High Very High
Spinal cord 6 98.76 Very High Very High Very High
Nerve growth factor 357 98.64 Very High Very High Very High
Central nervous system 3 98.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 42 99.66 Very High Very High Very High
Fibrosarcoma 42 98.64 Very High Very High Very High
Neurodegenerative Disease 2 98.32 Very High Very High Very High
Increased Venous Pressure Under Development 84 97.72 Very High Very High Very High
Fasciculation 21 96.12 Very High Very High Very High
Opiate Addiction 3 94.44 High High
Brain Injury 2 92.08 High High
Cv Unclassified Under Development 6 91.56 High High
Metastasis 21 87.24 High High
Cancer 42 86.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, in situ hybridization histochemistry experiments were employed to investigate the effect of chronic morphine treatment on synapsin I gene expression.
Gene_expression (expression) of synapsin I associated with morphine
1) Confidence 0.78 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750825 Disease Relevance 0.09 Pain Relevance 0.98
In perinatal morphine-treated rats, the expression of synapsin I mRNA was significantly reduced; interestingly, the neonatal treatment with 6-hydroxydopamine normalized its expression.
Gene_expression (expression) of synapsin I mRNA associated with morphine
2) Confidence 0.78 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8804907 Disease Relevance 0 Pain Relevance 0.90
Brain expression of synapsin I mRNA was particularly abundant in cerebral cortex, hippocampus, dentate gyrus and olfactory bulb.
Gene_expression (expression) of synapsin I mRNA in hippocampus associated with hippocampus and cerebral cortex
3) Confidence 0.78 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8804907 Disease Relevance 0 Pain Relevance 0.90
The pre- and postnatal brain expression of synapsin I mRNA is gradually and progressively localized in discrete areas of the brain.
Gene_expression (expression) of synapsin I mRNA in brain
4) Confidence 0.73 Published 1995 Journal J. Neurosci. Res. Section Abstract Doc Link 8568934 Disease Relevance 0 Pain Relevance 1.04
Therefore, perinatal exposure to morphine affects early postnatal synaptic development in the brain as shown by the altered peptidergic and monoaminergic content and by the reduced synapsin I mRNA expression.
Gene_expression (expression) of synapsin I mRNA in brain associated with monoamine and morphine
5) Confidence 0.73 Published 1995 Journal J. Neurosci. Res. Section Abstract Doc Link 8568934 Disease Relevance 0 Pain Relevance 0.93
In the brain of rats perinatally exposed to morphine, the abundance of synapsin I mRNA expression is markedly reduced.
Gene_expression (expression) of synapsin I mRNA in brain associated with morphine
6) Confidence 0.73 Published 1995 Journal J. Neurosci. Res. Section Abstract Doc Link 8568934 Disease Relevance 0 Pain Relevance 1.01
Increased expression of synapsin I mRNA was also observed in the spinal cord of morphine-treated rats (by 3.8-fold).
Gene_expression (expression) of synapsin I in spinal cord associated with morphine and spinal cord
7) Confidence 0.68 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750825 Disease Relevance 0.07 Pain Relevance 1.39
Increased expression of synapsin I mRNA in defined areas of the rat central nervous system following chronic morphine treatment.
Gene_expression (expression) of synapsin I in central nervous system associated with central nervous system and morphine
8) Confidence 0.68 Published 1995 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 8750825 Disease Relevance 0.09 Pain Relevance 0.99
The results suggest that continued activation of opiate receptors by chronic agonist treatment up-regulates the levels of synapsin I.
Gene_expression (levels) of synapsin I associated with agonist and opiate
9) Confidence 0.60 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8436965 Disease Relevance 0.14 Pain Relevance 1.21
There was a strong correlation between the expression of the PDE4A variants with that of synapsin I, which suggests that as neurons develop and signal transduction increases there is a regulated increase in PDE4 expression and activity.
Gene_expression (expression) of synapsin I in neurons
10) Confidence 0.42 Published 2001 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 11557100 Disease Relevance 0 Pain Relevance 0.20
We report here the effect of axotomy on the expression of glycine receptors, gephyrin, vesicular inhibitory amino acid transporter (VIAAT) and synapsin I in rat facial motor neurons as demonstrated by in situ hybridization and immunohistochemistry.
Gene_expression (expression) of synapsin I in motor neurons
11) Confidence 0.39 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15733085 Disease Relevance 0 Pain Relevance 0.07
The neuroprotective mechanisms were associated with increased CREB phosphorylation and increased brain-derived neurotrophic factor and synapsin I mRNA expression in the hippocampus.
Gene_expression (expression) of synapsin I mRNA in hippocampus associated with hippocampus
12) Confidence 0.29 Published 2006 Journal Neurobiol. Dis. Section Abstract Doc Link 16887358 Disease Relevance 1.07 Pain Relevance 0.75
Brain expression of synapsin I mRNA was particularly abundant in cerebral cortex, hippocampus, dentate gyrus and olfactory bulb.
Gene_expression (expression) of synapsin I mRNA in olfactory bulb associated with hippocampus and cerebral cortex
13) Confidence 0.26 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8804907 Disease Relevance 0 Pain Relevance 0.90
Brain expression of synapsin I mRNA was particularly abundant in cerebral cortex, hippocampus, dentate gyrus and olfactory bulb.
Gene_expression (expression) of synapsin I mRNA in dentate gyrus associated with hippocampus and cerebral cortex
14) Confidence 0.26 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8804907 Disease Relevance 0 Pain Relevance 0.90
Brain expression of synapsin I mRNA was particularly abundant in cerebral cortex, hippocampus, dentate gyrus and olfactory bulb.
Gene_expression (expression) of synapsin I mRNA in cerebral cortex associated with hippocampus and cerebral cortex
15) Confidence 0.26 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8804907 Disease Relevance 0 Pain Relevance 0.90
Thus, synapsin-1 labeling distinctly revealed large clusters present at extrasynaptic sites, whereas co-transfection of EGFP-Homer1c and mCherry-gephyrin indicated that ┬ôsynaptic┬ö ?
Gene_expression (labeling) of synapsin-1
16) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2901346 Disease Relevance 0 Pain Relevance 0.23
For example, glutamate-induced LTP in hippocampal cell cultures has been shown to promote an increase in the expression of the postsynaptically-localized protein GluR1 and the presynaptically-localized proteins synapsin I and synaptophysin, as well as a corresponding increase in co-localization of GluR1 and synaptophysin/synapsin I-labeled puncta [24].
Gene_expression (expression) of synapsin I associated with glutamate and long-term potentiation
17) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0 Pain Relevance 0.18
Moreover, Syn-1 was shown to be expressed maximally in periods of intense growth and synapse formation during neuron development and its ectopic overexpression increased the number of short dendritic varicosities in neurons [30].
Gene_expression (expressed) of Syn-1 in synapse associated with increased venous pressure under development
18) Confidence 0.18 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.36 Pain Relevance 0.15
This discrepancy may be due to the different levels of Syn-1 signaling, resulting from decreased or elevated expression of Syn-1, or reflect differences between mature hippocampal cells and neuroblast PC12 cells.
Gene_expression (expression) of Syn-1 in neuroblast
19) Confidence 0.18 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.42 Pain Relevance 0
Unlike these results, however, overexpression of Syn-1 in mature cultured hippocampal neurons was reported not to affect the number of branches [30].
Gene_expression (overexpression) of Syn-1 in neurons
20) Confidence 0.18 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.33 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox