INT60046

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Context Info
Confidence 0.70
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 2.00
Pain Relevance 13.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Syn1) ligase activity (Syn1)
Anatomy Link Frequency
neurons 1
spinal cord 1
brain 1
amygdala 1
hippocampus 1
Syn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 80 100.00 Very High Very High Very High
agonist 28 100.00 Very High Very High Very High
Spinal cord 16 99.68 Very High Very High Very High
long-term potentiation 39 99.66 Very High Very High Very High
Enkephalin 6 99.52 Very High Very High Very High
Morphine 20 99.42 Very High Very High Very High
Analgesic 9 99.30 Very High Very High Very High
dorsal root ganglion 12 99.20 Very High Very High Very High
Locus ceruleus 4 99.20 Very High Very High Very High
Hippocampus 22 98.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 12 98.72 Very High Very High Very High
Opiate Addiction 4 89.96 High High
Anxiety Disorder 228 83.84 Quite High
Stroke 15 80.08 Quite High
Brain Injury 10 47.88 Quite Low
Middle Cerebral Artery Infarction 12 40.16 Quite Low
Shock 61 5.00 Very Low Very Low Very Low
Overdose 6 5.00 Very Low Very Low Very Low
Brain Hemorrhage 3 5.00 Very Low Very Low Very Low
Aids-related Complex 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantitative analysis of the signals, obtained by hybridization of digoxigenin-labeled antisense RNA probe, revealed a 5.8- and 7-fold increase of synapsin I mRNA levels in the locus coeruleus and the amygdala of morphine-treated rats, respectively, as compared with control untreated rats.
Positive_regulation (increase) of synapsin I in amygdala associated with locus ceruleus, amygdala and morphine
1) Confidence 0.70 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750825 Disease Relevance 0.08 Pain Relevance 1.24
Since opiates were shown to attenuate neurotransmitter release and reduce synapsin I phosphorylation, it is suggested that the increase in synapsin I levels would lead to the requirement of higher amounts of opiate agonists to obtain the opiate physiological effects.
Positive_regulation (increase) of synapsin I associated with neurotransmitter, agonist and opiate
2) Confidence 0.70 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750825 Disease Relevance 0.06 Pain Relevance 1.40
Here we show that prolonged opiate treatment increases the levels of synapsin I immunoreactivity in the cells.
Positive_regulation (increases) of synapsin I associated with opiate
3) Confidence 0.70 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8436965 Disease Relevance 0.16 Pain Relevance 1.18
Several opiate agonists, such as U50488, ethylketocyclazocine, dynorphin, and [D-Ala2,D-Leu5]enkephalin, caused a 3.0-3.4-fold increase in the immunoreactive level of synapsin I.
Positive_regulation (increase) of synapsin I associated with dynorphin, agonist, enkephalin and opiate
4) Confidence 0.70 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8436965 Disease Relevance 0.16 Pain Relevance 1.24
The results suggest that continued activation of opiate receptors by chronic agonist treatment up-regulates the levels of synapsin I.
Positive_regulation (activation) of synapsin I associated with agonist and opiate
5) Confidence 0.70 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8436965 Disease Relevance 0.15 Pain Relevance 1.24
Long-term opiate exposure leads to increase in synapsin I in rat spinal cord-dorsal root ganglion cocultures.
Positive_regulation (increase) of synapsin I in spinal cord associated with ganglion cysts, dorsal root ganglion, analgesic, opiate and spinal cord
6) Confidence 0.70 Published 1993 Journal J. Neurochem. Section Title Doc Link 8436965 Disease Relevance 0.19 Pain Relevance 1.28
This increase in synapsin I could contribute to the development of tolerance to opiates.
Positive_regulation (increase) of synapsin I associated with tolerance and opiate
7) Confidence 0.70 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8436965 Disease Relevance 0.14 Pain Relevance 1.20
The effect of the kappa-agonist U50488 on the up-regulation of synapsin I was dose dependent and was blocked by the kappa-opiate antagonist norbinaltor-phimine.
Positive_regulation (up-regulation) of synapsin I associated with antagonist, agonist and opiate
8) Confidence 0.50 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8436965 Disease Relevance 0.15 Pain Relevance 1.24
We show here for the first time that prolonged morphine exposure causes a selective increase in the mRNA levels of synapsin I in several brain regions which are considered to be important for opiate action.
Positive_regulation (increase) of synapsin I in brain associated with opiate and morphine
9) Confidence 0.47 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750825 Disease Relevance 0.09 Pain Relevance 1.05
These results suggest that the increases in mRNA levels of synapsin I in these specific areas can be part of the molecular mechanism(s) underlying opiate tolerance and withdrawal.
Positive_regulation (increases) of synapsin I associated with tolerance, opiate and withdrawal
10) Confidence 0.47 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750825 Disease Relevance 0.06 Pain Relevance 1.31
The increase in activity was accompanied by an increase in the expression of the PDE4A variants, PDE4A5 and PDE4A1, as well as of the synaptic marker protein synapsin I.
Positive_regulation (increase) of synapsin I
11) Confidence 0.33 Published 2001 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 11557100 Disease Relevance 0 Pain Relevance 0.19
Vaynman et al. (27) reported that exercise-induced increases in synapsin I and synaptophysin in the hippocampus were abrogated by blocking of interaction between BDNF and the BDNF receptor TrkB.
Positive_regulation (increases) of synapsin I in hippocampus associated with hippocampus
12) Confidence 0.30 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967002 Disease Relevance 0.16 Pain Relevance 0.16
There was a strong correlation between the expression of the PDE4A variants with that of synapsin I, which suggests that as neurons develop and signal transduction increases there is a regulated increase in PDE4 expression and activity.
Positive_regulation (increases) of synapsin I in neurons
13) Confidence 0.25 Published 2001 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 11557100 Disease Relevance 0 Pain Relevance 0.21
Of particular relevance to the present manuscript, LTP induced by glutamate application in hippocampal cell cultures has been observed to lead to an increase in GluR1, synaptophysin, and synapsin I labeled puncta, as well as a corresponding increase in the number of sites where GluR1 and synaptophysin/synapsin I are co-localized [24].
Positive_regulation (increase) of synapsin I associated with glutamate and long-term potentiation
14) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.29 Pain Relevance 0.41
Conversely, application of exogenous NO or cGMP analogs alone induces LTP and promotes an increase in clusters of both GluR1 and synaptophysin/synapsin I puncta [26].
Positive_regulation (increase) of synapsin I associated with long-term potentiation
15) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.31 Pain Relevance 0.35
For example, glutamate-induced LTP in hippocampal cell cultures has been shown to promote an increase in the expression of the postsynaptically-localized protein GluR1 and the presynaptically-localized proteins synapsin I and synaptophysin, as well as a corresponding increase in co-localization of GluR1 and synaptophysin/synapsin I-labeled puncta [24].
Positive_regulation (increase) of synapsin I associated with glutamate and long-term potentiation
16) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0 Pain Relevance 0.18

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