INT60064

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Context Info
Confidence 0.05
First Reported 1993
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.68
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NPEPPS) peptidase activity (NPEPPS) nucleus (NPEPPS)
cytoplasm (NPEPPS)
Anatomy Link Frequency
articular cartilage 2
NPEPPS (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 18 100.00 Very High Very High Very High
Osteoarthritis 2 97.96 Very High Very High Very High
cytokine 1 94.92 High High
Pain 1 90.24 High High
cINOD 4 77.96 Quite High
Inflammation 2 71.32 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 3 97.96 Very High Very High Very High
Pain 1 90.24 High High
INFLAMMATION 4 77.40 Quite High
Arthropathy 2 72.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At concentrations that included those present in synovial fluids of patients treated with the drug, naproxen sodium was found to suppress the release of proteoglycan and neutral metalloproteinase activity from the articular cartilage extracts.
Negative_regulation (suppress) of Localization (release) of metalloproteinase in articular cartilage associated with metalloproteinase
1) Confidence 0.05 Published 1993 Journal J Clin Pharmacol Section Abstract Doc Link 8440758 Disease Relevance 0.22 Pain Relevance 0.45
The effect of naproxen sodium on the IL-1-stimulated release was to suppress, but not totally overcome, the increased release of proteoglycan and neutral metalloproteinase activity.
Neg (not) Negative_regulation (suppress) of Localization (release) of metalloproteinase associated with metalloproteinase
2) Confidence 0.03 Published 1993 Journal J Clin Pharmacol Section Abstract Doc Link 8440758 Disease Relevance 0.18 Pain Relevance 0.41
We tested the hypothesis that hyaluronan inhibited interleukin-1beta-induced matrix metalloproteinase activity secreted by explants of synovial tissue from patients with osteoarthritis and investigated the mechanism of the effect.
Negative_regulation (inhibited) of Localization (secreted) of metalloproteinase associated with metalloproteinase and osteoarthritis
3) Confidence 0.03 Published 2007 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 18090474 Disease Relevance 0.28 Pain Relevance 0.41

General Comments

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