INT60065

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Context Info
Confidence 0.22
First Reported 1993
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.07
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NPEPPS) peptidase activity (NPEPPS) nucleus (NPEPPS)
cytoplasm (NPEPPS)
Anatomy Link Frequency
stellate cells 2
heart 2
NPEPPS (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 16 100.00 Very High Very High Very High
fibrosis 7 99.92 Very High Very High Very High
Enkephalin 1 90.44 High High
MU agonist 1 89.32 High High
alcohol 4 85.36 High High
Chronic pancreatitis 2 74.64 Quite High
cINOD 2 61.32 Quite High
Inflammation 1 54.68 Quite High
Disease Link Frequency Relevance Heat
Fibrosis 7 99.92 Very High Very High Very High
Infarction 2 97.00 Very High Very High Very High
Hepatotoxicity 1 80.60 Quite High
Pancreatitis 2 74.64 Quite High
INFLAMMATION 2 60.76 Quite High
Arthropathy 1 55.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Secretion of matrix metalloproteinase from pancreatic stellate cells is increased by diethyldithiocarbamate stimulation.
Positive_regulation (increased) of Localization (Secretion) of metalloproteinase in stellate cells associated with metalloproteinase
1) Confidence 0.22 Published 2007 Journal Rinsho Byori Section Abstract Doc Link 17882797 Disease Relevance 0.71 Pain Relevance 0.71
The effect of naproxen sodium on the IL-1-stimulated release was to suppress, but not totally overcome, the increased release of proteoglycan and neutral metalloproteinase activity.
Neg (not) Positive_regulation (increased) of Localization (release) of metalloproteinase associated with metalloproteinase
2) Confidence 0.04 Published 1993 Journal J Clin Pharmacol Section Abstract Doc Link 8440758 Disease Relevance 0.17 Pain Relevance 0.40
We conclude that ACh-induced ROS generation in myocytes is mediated via transactivation of EGFR through metalloproteinase-dependent release of HB-EGF, and that this pathway is also operative in the intact heart and is required for ACh's cardioprotection.
Positive_regulation (transactivation) of Localization (release) of metalloproteinase in heart associated with metalloproteinase
3) Confidence 0.00 Published 2004 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 15010282 Disease Relevance 0.19 Pain Relevance 0.30

General Comments

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