INT60066

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Context Info
Confidence 0.22
First Reported 1993
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 17
Total Number 18
Disease Relevance 11.99
Pain Relevance 4.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NPEPPS) peptidase activity (NPEPPS) nucleus (NPEPPS)
cytoplasm (NPEPPS)
Anatomy Link Frequency
cartilage 1
tendon 1
autonomic nervous system 1
Tooth 1
lung 1
NPEPPS (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 143 100.00 Very High Very High Very High
rheumatoid arthritis 63 99.80 Very High Very High Very High
Inflammation 43 99.80 Very High Very High Very High
cytokine 27 99.68 Very High Very High Very High
aspirin 6 98.32 Very High Very High Very High
Pain 41 98.10 Very High Very High Very High
methotrexate 5 96.24 Very High Very High Very High
Osteoarthritis 5 95.16 Very High Very High Very High
Neuropeptide 3 91.12 High High
imagery 13 90.16 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 63 99.80 Very High Very High Very High
INFLAMMATION 53 99.80 Very High Very High Very High
Adenocarcinoma 9 99.22 Very High Very High Very High
Stress 15 99.18 Very High Very High Very High
Breast Cancer 59 99.12 Very High Very High Very High
Thoracic Aortic Aneurysm 22 99.04 Very High Very High Very High
Disease 36 98.54 Very High Very High Very High
Injury 174 98.48 Very High Very High Very High
Pain 39 98.10 Very High Very High Very High
Acute Coronary Syndrome 3 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There are elevated levels of matrix metalloproteinase and inflammatory cytokines, decreased levels of metalloproteinase tissue inhibitors, and growth factors in the chronic wound environment (Templeton 2005; Wright et al 2003).
Positive_regulation (elevated) of metalloproteinase associated with inflammation, injury, metalloproteinase and cytokine
1) Confidence 0.22 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676636 Disease Relevance 2.34 Pain Relevance 0.27
Results: Analysis yielded the following Yale-generated observations: (1) TAA is a genetic disease with a predominantly autosomal dominant mode of inheritance; (2) matrix metalloproteinase (MMP) enzymes are activated in the pathogenesis of TAA; (3) wall tension in TAA approaches the tensile limits of aortic tissue at a diameter of 6 cm; (4) by the time a TAA reaches a clinical diameter of 6 cm, 34 percent of affected patients have suffered dissection or rupture; (5) extreme physical exertion or severe emotion often precipitate acute dissection; and (6) single nucleotide polymorphisms (SNPs) and RNA expression profile changes are being identified that predispose a patient to TAA and can serve as biomarkers for screening for this virulent disease.
Positive_regulation (activated) of metalloproteinase associated with rupture, metalloproteinase, thoracic aortic aneurysm and disease
2) Confidence 0.06 Published 2008 Journal Yale J Biol Med Section Abstract Doc Link PMC2605304 Disease Relevance 1.27 Pain Relevance 0.15
It indicates that lung adenocarcinoma G1 should be considered as a possible target for metalloproteinase inhibitory therapy.
Spec (possible) Positive_regulation (target) of metalloproteinase in lung associated with adenocarcinoma and metalloproteinase
3) Confidence 0.06 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12044784 Disease Relevance 0.71 Pain Relevance 0.24
Moreover the induction of metalloproteinase gene appears to utilise the c-jun oncogene as intracellular messenger.
Positive_regulation (induction) of metalloproteinase associated with metalloproteinase
4) Confidence 0.06 Published 1999 Journal Anticancer Res. Section Abstract Doc Link 10216507 Disease Relevance 0.49 Pain Relevance 0.14
OBJECTIVE: Tooth pain can induce a neurogenic inflammatory reaction in gingiva in association with local elevations of matrix metalloproteinase (MMP)-8, which is considered the major tissue destructive protease in gingival crevice fluid (GCF).
Positive_regulation (elevations) of metalloproteinase in Tooth associated with pain, inflammation and metalloproteinase
5) Confidence 0.05 Published 2008 Journal Acta Odontol. Scand. Section Abstract Doc Link 18320414 Disease Relevance 0.36 Pain Relevance 0.71
AM; amniotic membrane, AMT; amniotic membrane transplantation, BCVA; the best corrected visual acuities, DLKP; deep lamellar keratoplasty, MMP; matrix metalloproteinase, TIMP; tissue inhibitor of metalloproteinase

Competing interests

Positive_regulation (matrix) of metalloproteinase associated with metalloproteinase
6) Confidence 0.05 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1913057 Disease Relevance 0.55 Pain Relevance 0.16
Hyaluronan with a molecular mass of 12.8 MDa (number average) antagonized induced metalloproteinase activity in proportion to hyaluronan concentration in the clinically relevant range of 2 to 8 mg/mL.
Positive_regulation (induced) of metalloproteinase associated with metalloproteinase
7) Confidence 0.04 Published 2007 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 18090474 Disease Relevance 0.31 Pain Relevance 0.45
The effect of hyaluronan on induced metalloproteinase activity was mediated partially by CD44, the principal cell surface receptor for hyaluronan.
Positive_regulation (induced) of metalloproteinase associated with metalloproteinase
8) Confidence 0.04 Published 2007 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 18090474 Disease Relevance 0.29 Pain Relevance 0.41
The effect of naproxen sodium on the IL-1-stimulated release was to suppress, but not totally overcome, the increased release of proteoglycan and neutral metalloproteinase activity.
Neg (not) Positive_regulation (increased) of metalloproteinase associated with metalloproteinase
9) Confidence 0.04 Published 1993 Journal J Clin Pharmacol Section Abstract Doc Link 8440758 Disease Relevance 0.17 Pain Relevance 0.40
The "apoptosis theory" [143-145] proposed by Murrell also neglect the fact of increased cellularity; but this hypothesis linked up oxidative stress, acquisition of cartilage phenotype and activation of metalloproteinase with the development of degenerative injuries by high dose of cyclic strain.
Positive_regulation (activation) of metalloproteinase in cartilage associated with stress, injury, metalloproteinase, sprains and strains and apoptosis
10) Confidence 0.03 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC3006368 Disease Relevance 1.42 Pain Relevance 0.09
Two matrix metalloproteinase were upregulated (MMP2 and an MIFR1), whereas ADAM metallopeptidase domain 3A was significantly downregulated.
Positive_regulation (upregulated) of metalloproteinase associated with metalloproteinase
11) Confidence 0.02 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2828399 Disease Relevance 0.30 Pain Relevance 0.09
Human breast cancer cell-mediated bone collagen degradation requires plasminogen activation and matrix metalloproteinase activity

Background

Positive_regulation (activation) of metalloproteinase associated with breast cancer and metalloproteinase
12) Confidence 0.01 Published 2005 Journal Cancer Cell Int Section Title Doc Link PMC548674 Disease Relevance 0.59 Pain Relevance 0.14
Antibodies from RA patients support metalloproteinase activity by neutralizing TIMP-2
Positive_regulation (support) of metalloproteinase associated with metalloproteinase and rheumatoid arthritis
13) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.80 Pain Relevance 0.50
Increased matrix metalloproteinase activity and autonomic nervous system dysfunction have also been described as possible etiologies [8].
Positive_regulation (Increased) of metalloproteinase in autonomic nervous system associated with metalloproteinase
14) Confidence 0.01 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2958974 Disease Relevance 1.38 Pain Relevance 0.14
It is proposed that some metalloproteinase enzymes are required for the health of the tendon, and others may be damaging, leading to degeneration of the tissue.
Positive_regulation (required) of metalloproteinase in tendon associated with metalloproteinase
15) Confidence 0.01 Published 2005 Journal Scand J Med Sci Sports Section Abstract Doc Link 15998341 Disease Relevance 0.42 Pain Relevance 0.19
Inactivation of phospholipase A2 and metalloproteinase from Crotalus atrox venom by direct current.
Positive_regulation (Inactivation) of metalloproteinase associated with metalloproteinase
16) Confidence 0.00 Published 2007 Journal J. Biochem. Mol. Toxicol. Section Title Doc Link 17366544 Disease Relevance 0.15 Pain Relevance 0.24
ACh caused a 36 +/- 6% increase in fluorescence (P<0.001) and metalloproteinase inhibitor III (MPI) abolished this increase.
Positive_regulation (increase) of metalloproteinase associated with metalloproteinase
17) Confidence 0.00 Published 2004 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 15010282 Disease Relevance 0 Pain Relevance 0.17
There is increasing evidence that abnormal cytokine expression and increased metalloproteinase activity are implicated in the pathophysiology of acute coronary syndromes.
Positive_regulation (increased) of metalloproteinase associated with acute coronary syndrome, metalloproteinase and cytokine
18) Confidence 0.00 Published 2004 Journal Int. J. Cardiol. Section Abstract Doc Link 15093992 Disease Relevance 0.45 Pain Relevance 0.33

General Comments

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