INT60067

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Context Info
Confidence 0.26
First Reported 1993
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 3.36
Pain Relevance 4.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NPEPPS) peptidase activity (NPEPPS) nucleus (NPEPPS)
cytoplasm (NPEPPS)
Anatomy Link Frequency
cartilage 2
articular cartilage 2
blood 1
stellate cells 1
heart 1
NPEPPS (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 50 100.00 Very High Very High Very High
fibrosis 7 99.92 Very High Very High Very High
Inflammation 6 98.48 Very High Very High Very High
Osteoarthritis 47 97.96 Very High Very High Very High
Arthritis 1 97.96 Very High Very High Very High
cytokine 1 93.20 High High
cINOD 10 90.92 High High
Enkephalin 1 89.16 High High
Pain 6 88.52 High High
MU agonist 1 88.04 High High
Disease Link Frequency Relevance Heat
Fibrosis 7 99.92 Very High Very High Very High
Arthritis 1 98.48 Very High Very High Very High
Osteoarthritis 48 97.96 Very High Very High Very High
Infarction 2 95.72 Very High Very High Very High
Hypercalcemia 22 92.96 High High
INFLAMMATION 10 90.36 High High
Emergencies 1 88.72 High High
Pain 3 88.52 High High
Arthropathy 5 85.56 High High
Hepatotoxicity 1 80.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Secretion of matrix metalloproteinase from pancreatic stellate cells is increased by diethyldithiocarbamate stimulation.
Localization (Secretion) of metalloproteinase in stellate cells associated with metalloproteinase
1) Confidence 0.26 Published 2007 Journal Rinsho Byori Section Abstract Doc Link 17882797 Disease Relevance 0.65 Pain Relevance 0.67
At concentrations that included those present in synovial fluids of patients treated with the drug, naproxen sodium was found to suppress the release of proteoglycan and neutral metalloproteinase activity from the articular cartilage extracts.
Localization (release) of metalloproteinase in articular cartilage associated with metalloproteinase
2) Confidence 0.06 Published 1993 Journal J Clin Pharmacol Section Abstract Doc Link 8440758 Disease Relevance 0.22 Pain Relevance 0.44
Release of proteoglycan from the cartilage was compared with release of neutral metalloproteinase activity.
Localization (release) of metalloproteinase in cartilage associated with metalloproteinase
3) Confidence 0.06 Published 1993 Journal J Clin Pharmacol Section Abstract Doc Link 8440758 Disease Relevance 0.26 Pain Relevance 0.42
Other blood tests focus on myosin heavy chain and metalloproteinase release for the aortic media during dissection.
Localization (release) of metalloproteinase in blood associated with metalloproteinase
4) Confidence 0.06 Published 2008 Journal Am J Emerg Med Section Abstract Doc Link 18926356 Disease Relevance 0.18 Pain Relevance 0.18
The effect of the drug also was determined on the IL-1-stimulated release of proteoglycan and neutral metalloproteinase activity from the explants.
Spec (determined) Localization (release) of metalloproteinase associated with metalloproteinase
5) Confidence 0.06 Published 1993 Journal J Clin Pharmacol Section Abstract Doc Link 8440758 Disease Relevance 0.25 Pain Relevance 0.45
This is in contrast to the well-documented effect of interleukin-1 (IL-1), which was shown to stimulate release of proteoglycan and neutral metalloproteinase activity from articular cartilage.
Localization (release) of metalloproteinase in articular cartilage associated with metalloproteinase
6) Confidence 0.06 Published 1993 Journal J Clin Pharmacol Section Abstract Doc Link 8440758 Disease Relevance 0.20 Pain Relevance 0.43
The effect of naproxen sodium on the IL-1-stimulated release was to suppress, but not totally overcome, the increased release of proteoglycan and neutral metalloproteinase activity.
Localization (release) of metalloproteinase associated with metalloproteinase
7) Confidence 0.06 Published 1993 Journal J Clin Pharmacol Section Abstract Doc Link 8440758 Disease Relevance 0.17 Pain Relevance 0.40
We tested the hypothesis that hyaluronan inhibited interleukin-1beta-induced matrix metalloproteinase activity secreted by explants of synovial tissue from patients with osteoarthritis and investigated the mechanism of the effect.
Localization (secreted) of metalloproteinase associated with metalloproteinase and osteoarthritis
8) Confidence 0.04 Published 2007 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 18090474 Disease Relevance 0.28 Pain Relevance 0.41
Cartilage degradation can be assessed using the C-terminal telopeptide of type II collagen (CTX-II), which is a Matrix Metalloproteinase (MMP)-generated fragment released during cartilage degradation in both inflammatory arthritis and OA [23,24].
Localization (released) of Metalloproteinase in Cartilage associated with inflammation, metalloproteinase, osteoarthritis and arthritis
9) Confidence 0.01 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2902412 Disease Relevance 0.98 Pain Relevance 0.46
We conclude that ACh-induced ROS generation in myocytes is mediated via transactivation of EGFR through metalloproteinase-dependent release of HB-EGF, and that this pathway is also operative in the intact heart and is required for ACh's cardioprotection.
Localization (release) of metalloproteinase in heart associated with metalloproteinase
10) Confidence 0.00 Published 2004 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 15010282 Disease Relevance 0.19 Pain Relevance 0.29

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