INT60151

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Context Info
Confidence 0.45
First Reported 1993
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.54
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HSD11B1) oxidoreductase activity (HSD11B1) endoplasmic reticulum (HSD11B1)
Anatomy Link Frequency
plasma 2
heart 2
HSD11B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 5 99.58 Very High Very High Very High
Adalimumab 3 99.54 Very High Very High Very High
agonist 4 89.52 High High
Infliximab 12 87.60 High High
Angina 4 75.00 Quite High
Inflammation 17 58.88 Quite High
rheumatoid arthritis 82 50.52 Quite High
Arthritis 4 33.48 Quite Low
spinal inflammation 1 32.56 Quite Low
Etanercept 3 23.56 Low Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 98 100.00 Very High Very High Very High
Impaired Glucose Tolerance 3 99.58 Very High Very High Very High
Heart Disease 7 97.50 Very High Very High Very High
Metabolic Syndrome 35 97.32 Very High Very High Very High
Diabetes Mellitus 39 93.80 High High
Disease 41 90.40 High High
Myocardial Infarction 23 89.20 High High
Syndrome 3 87.80 High High
Stroke 6 86.80 High High
Reprotox - General 1 8 86.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Via an improvement in glucose tolerance, ACE-inhibitors can contribute to a lowering of triglyceride concentrations and an increase in the HDL cholesterol levels.
Positive_regulation (contribute) of Positive_regulation (increase) of HDL associated with tolerance, disorder of lipid metabolism and impaired glucose tolerance
1) Confidence 0.45 Published 1993 Journal Fortschr. Med. Section Abstract Doc Link 8449471 Disease Relevance 0.35 Pain Relevance 0.12
In ASCOT-LLA, over 10,000 men and women without heart disease were given atorvastatin 10 mg versus placebo.14 The dose of atorvastatin used produced a 36% reduction in LDL-C but did not lead to an increase in HDL-C as we had seen in all the previous statin studies.
Neg (not) Positive_regulation (lead) of Positive_regulation (increase) of HDL in heart associated with heart disease and disorder of lipid metabolism
2) Confidence 0.45 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Body Doc Link PMC2978935 Disease Relevance 0.95 Pain Relevance 0.03
In a two week placebo-controlled study with another TNF blocking agent, ie, adalimumab, the investigators observed, in the 33 adalimumab treated patients a 6% increase in TC levels (5.02 vs 4.70 at baseline) as well as a 15% increase in HDL-C levels (0.98 mmol/L (37.7 mg/dL) vs 0.86 mmol/L (33.1 mg/dL) at baseline) after two weeks treatment (Popa et al 2005).
Positive_regulation (increase) of Positive_regulation (increase) of HDL associated with adalimumab and disorder of lipid metabolism
3) Confidence 0.23 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350142 Disease Relevance 0.84 Pain Relevance 0.22
Collectively, these studies have found that ADT leads to an increase in fat mass, an increase in plasma insulin, decreased insulin sensitivity (48), increased levels of glycosylated haemoglobin, an increase in plasma cholesterol, LDL-cholesterol and triglycerides but also an increase in plasma HDL-cholesterol, which contrasts with the low HDL-cholesterol levels found in the metabolic syndrome.
Positive_regulation (increased) of Positive_regulation (increase) of HDL-cholesterol in plasma associated with metabolic syndrome and disorder of lipid metabolism
4) Confidence 0.01 Published 2008 Journal International Journal of Clinical Practice Section Body Doc Link PMC2327081 Disease Relevance 1.41 Pain Relevance 0.11

General Comments

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