INT60162

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Context Info
Confidence 0.58
First Reported 1993
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 41
Total Number 42
Disease Relevance 23.77
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
M83 1
neuronal 1
tails 1
dendritic cells 1
cerebellum 1
Ie (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 6 99.28 Very High Very High Very High
imagery 173 92.80 High High
gABA 4 87.96 High High
Multiple sclerosis 21 82.24 Quite High
cerebral cortex 8 80.36 Quite High
Hippocampus 41 79.56 Quite High
Mechanotransduction 2 75.00 Quite High
Lasting pain 12 74.96 Quite High
Peripheral nervous system 24 70.84 Quite High
Neurotransmitter 10 69.00 Quite High
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 1265 100.00 Very High Very High Very High
Pseudorabies 60 100.00 Very High Very High Very High
Targeted Disruption 69 99.88 Very High Very High Very High
Cold Sores 2021 99.84 Very High Very High Very High
Hypertrophy 10 99.84 Very High Very High Very High
Infection 973 99.78 Very High Very High Very High
Viral Meningitis 24 98.90 Very High Very High Very High
Sprains And Strains 481 98.68 Very High Very High Very High
Malaria 168 98.04 Very High Very High Very High
Contagious Ecthyma 183 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro, LBP has been demonstrated to induce maturation of murine bone marrow-derived dendritic cells to secrete IL-12 p40 and increase the expression of membrane markers I-A/I-E and CD11c [45].
Gene_expression (expression) of I-E in dendritic cells
1) Confidence 0.58 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723674 Disease Relevance 1.15 Pain Relevance 0.07
RT-PCR examining expression of pp65, IE1, IE2, and pol mRNA in infected cells
Gene_expression (expression) of IE1
2) Confidence 0.16 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 1.02 Pain Relevance 0
The ie1 forward primers: 5?
Gene_expression (primers) of ie1
3) Confidence 0.16 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 0.86 Pain Relevance 0
At week 3 of infection, two mice in each of the four groups were examined for expression of MCMV IE1 mRNA in aortic tissues.
Gene_expression (expression) of IE1 associated with cytomegalovirus infection and infection
4) Confidence 0.16 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 1.82 Pain Relevance 0.03
Considering this, the expression of ICP0 could, in part, promote changes in the chromatin profiles of IE lytic promoters from a less transcriptionally permissive state to a more transcriptionally permissive one, [59] potentially causing a cascade of IE gene expression.
Gene_expression (expression) of IE gene
5) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.23 Pain Relevance 0
While NaB is known to have pleotropic effects in vivo, one fact that cannot be overlooked is that NaB is a known histone deacetylase inhibitor (HDACI), and as such, using NaB to stimulate in vivo reactivation in the mouse model has raised an important question with respect to the epigenetic regulation of HSV-1 reactivation; were the increased enrichments of acetylated histone marks on the IE promoters following NaB treatment merely a global consequence of the application of the HDACI and not a fundamental element in the molecular mechanisms that ultimately govern the process of HSV-1 reactivation?
Gene_expression (promoters) of IE associated with cold sores
6) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.70 Pain Relevance 0.03
In order to answer this question and to begin to define the potential of epigenetic changes to the HSV-1 genome as a function of the reactivation process, we outlined studies with the following objectives: 1) to stimulate HSV-1 reactivation in an animal model using an efficient reactivation method not capable of directly modify histone tails; 2) to determine whether changes in the enrichment of a euchromatic histone marker could be observed for the LAT and IE regions of HSV-1 following reactivation stimuli; 3) to correlate any changes in the enrichments of euchromatic marks to LAT and lytic transcript abundance; and 4) to determine whether wild-type HSV-1 strains with different reactivation phenotypes established dissimilar profiles of euchromatic marker enrichments on the LAT and IE regions during latency and/or following the application of a reactivation stimulus.
Gene_expression (regions) of IE in tails associated with cold sores and sprains and strains
7) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.86 Pain Relevance 0
The H3K4me2 enrichment does not extend to the IE regions of ICP0 and ICP4 in the rabbit TG, a finding that remains consistent with the previously published reports.
Gene_expression (regions) of IE
8) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.59 Pain Relevance 0
This finding, coupled with the unchanging abundance of LAT RNA indicate that changes in histone markers on the LAT and the IE regions of HSV-1 may be a crucial factor in in vivo reactivation.
Gene_expression (regions) of IE associated with cold sores
9) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.58 Pain Relevance 0
Previous studies identified changes in the acetyl-H3K9K14 associated with the LAT and IE regions of HSV-1 following the application of a reactivation stimulus in mice [19], [59].
Gene_expression (regions) of IE associated with cold sores
10) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.27 Pain Relevance 0
During latent infection, the viral genome persists as a stable episomal element, without detectable expression of IE, E or L gene products.
Gene_expression (expression) of IE associated with infection
11) Confidence 0.12 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.45 Pain Relevance 0
exon region of HSV-1 maintains a significantly enriched H3 K4me2 chromatin profile relative to the IE regions during latency in the rabbit TG
Gene_expression (regions) of IE associated with cold sores
12) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.47 Pain Relevance 0
In contrast, we could not detect any significant changes in either the enrichment of H3K4me2 of the LAT and IE regions of the inefficient reactivating strain, KOS following TCIE through 4 hours.
Gene_expression (regions) of IE associated with sprains and strains
13) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.56 Pain Relevance 0
CMV IE-1 expression correlates with known sites of human CMV infection [30], and IE-1 expression is required for CMV reactivation [27].
Gene_expression (expression) of IE-1 associated with cytomegalovirus infection and infection
14) Confidence 0.11 Published 2003 Journal BMC Physiol Section Body Doc Link PMC194750 Disease Relevance 1.00 Pain Relevance 0.05
Cascade expression of the viral IE, E, and L genes resumes, resulting in the production of mature virions.
Gene_expression (expression) of IE
15) Confidence 0.10 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.51 Pain Relevance 0.05
To date, several replication-defective vectors have been constructed in which the IE genes, expressing ICP 0, 4, 22, 27, and 47, have been deleted in various combinations [28-30].
Gene_expression (expressing) of IE
16) Confidence 0.09 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.14 Pain Relevance 0.19
CMV IE-1 expression correlates with known sites of human CMV infection [30], and IE-1 expression is required for CMV reactivation [27].
Gene_expression (expression) of IE-1 associated with cytomegalovirus infection and infection
17) Confidence 0.09 Published 2003 Journal BMC Physiol Section Body Doc Link PMC194750 Disease Relevance 0.99 Pain Relevance 0.04
Neither disruption of microtubules with colchicine nor that of actin microfilaments by cytochalasin D prevented the stretch-induced IE gene expression.
Gene_expression (expression) of IE gene
18) Confidence 0.07 Published 1993 Journal J. Recept. Res. Section Abstract Doc Link 8450511 Disease Relevance 0.42 Pain Relevance 0.13
Arresting contractile activity by tetrodotoxin did not affect the stretch-induced IE gene expression or hypertrophy.
Gene_expression (expression) of IE gene associated with tetrodotoxin and hypertrophy
19) Confidence 0.07 Published 1993 Journal J. Recept. Res. Section Abstract Doc Link 8450511 Disease Relevance 0.41 Pain Relevance 0.14
Wet preparations were viewed on a fluroescence microscope (400× magnification) and at least 500 IE were counted and scored for clumping from each slide, with a clump being defined as three or more adherent IE.
Gene_expression (counted) of IE
20) Confidence 0.07 Published 2008 Journal Malar J Section Body Doc Link PMC2599902 Disease Relevance 0.06 Pain Relevance 0.06

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