INT60165

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Context Info
Confidence 0.10
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 3.50
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Ie (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 2 99.44 Very High Very High Very High
imagery 45 93.76 High High
Mechanotransduction 2 75.00 Quite High
monoamine 2 56.28 Quite High
Hippocampus 10 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Eae 4 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
Thalamus 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 10 99.84 Very High Very High Very High
Cytomegalovirus Infection 145 99.80 Very High Very High Very High
Infection 50 99.78 Very High Very High Very High
Cold Sores 202 99.48 Very High Very High Very High
Viral Infection 4 91.04 High High
Sprains And Strains 94 85.48 High High
Targeted Disruption 29 75.36 Quite High
Overdose 16 75.16 Quite High
Pseudorabies 20 50.00 Quite Low
Cognitive Disorder 38 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While NaB is known to have pleotropic effects in vivo, one fact that cannot be overlooked is that NaB is a known histone deacetylase inhibitor (HDACI), and as such, using NaB to stimulate in vivo reactivation in the mouse model has raised an important question with respect to the epigenetic regulation of HSV-1 reactivation; were the increased enrichments of acetylated histone marks on the IE promoters following NaB treatment merely a global consequence of the application of the HDACI and not a fundamental element in the molecular mechanisms that ultimately govern the process of HSV-1 reactivation?
Positive_regulation (following) of Gene_expression (promoters) of IE associated with cold sores
1) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.70 Pain Relevance 0.03
While NaB is known to have pleotropic effects in vivo, one fact that cannot be overlooked is that NaB is a known histone deacetylase inhibitor (HDACI), and as such, using NaB to stimulate in vivo reactivation in the mouse model has raised an important question with respect to the epigenetic regulation of HSV-1 reactivation; were the increased enrichments of acetylated histone marks on the IE promoters following NaB treatment merely a global consequence of the application of the HDACI and not a fundamental element in the molecular mechanisms that ultimately govern the process of HSV-1 reactivation?
Positive_regulation (increased) of Gene_expression (promoters) of IE associated with cold sores
2) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.71 Pain Relevance 0.03
CMV IE-1 expression correlates with known sites of human CMV infection [30], and IE-1 expression is required for CMV reactivation [27].
Positive_regulation (required) of Gene_expression (expression) of IE-1 associated with cytomegalovirus infection and infection
3) Confidence 0.08 Published 2003 Journal BMC Physiol Section Body Doc Link PMC194750 Disease Relevance 1.01 Pain Relevance 0.05
Arresting contractile activity by tetrodotoxin did not affect the stretch-induced IE gene expression or hypertrophy.
Positive_regulation (induced) of Gene_expression (expression) of IE gene associated with tetrodotoxin and hypertrophy
4) Confidence 0.07 Published 1993 Journal J. Recept. Res. Section Abstract Doc Link 8450511 Disease Relevance 0.41 Pain Relevance 0.14
Neither disruption of microtubules with colchicine nor that of actin microfilaments by cytochalasin D prevented the stretch-induced IE gene expression.
Positive_regulation (induced) of Gene_expression (expression) of IE gene
5) Confidence 0.07 Published 1993 Journal J. Recept. Res. Section Abstract Doc Link 8450511 Disease Relevance 0.42 Pain Relevance 0.13
0.01) than those collected during the habituation sessions from the 3rd to the 5th conditioning sessions, whilst the TgIE96 group presented percentages of CRs significantly (P ?
Positive_regulation (percentages) of Gene_expression (presented) of TgIE96
6) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920824 Disease Relevance 0 Pain Relevance 0
0.01) than those collected during the habituation sessions from the 2nd to the 5th conditioning sessions, whilst the TgIE96 group presented percentages of CRs significantly (P ?
Positive_regulation (percentages) of Gene_expression (presented) of TgIE96
7) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920824 Disease Relevance 0 Pain Relevance 0
The results presented here reveal surprising dissimilarities in the properties of primate cytomegalovirus UL82 homologs, despite the fact that each of the proteins is a potent transactivator of IE gene expression.
Positive_regulation (transactivator) of Gene_expression (expression) of IE associated with cytomegalovirus infection
8) Confidence 0.04 Published 2009 Journal Virol J Section Body Doc Link PMC2693105 Disease Relevance 0.24 Pain Relevance 0

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