INT60172

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Context Info
Confidence 0.75
First Reported 1993
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 2.76
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Htr5b) plasma membrane (Htr5b) signal transducer activity (Htr5b)
Anatomy Link Frequency
platelet 2
coronary artery 1
plasma 1
head 1
hippocampus 1
Htr5b (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 19 100.00 Very High Very High Very High
Neurotransmitter 4 99.56 Very High Very High Very High
Analgesic 5 98.88 Very High Very High Very High
Sumatriptan 4 97.84 Very High Very High Very High
Hippocampus 2 97.64 Very High Very High Very High
monoamine 24 97.60 Very High Very High Very High
addiction 24 89.52 High High
antagonist 1 85.20 High High
sSRI 8 84.64 Quite High
depression 4 82.08 Quite High
Disease Link Frequency Relevance Heat
Nicotine Addiction 684 99.58 Very High Very High Very High
Coronary Artery Disease 8 98.40 Very High Very High Very High
Mental Disorders 4 91.72 High High
Cancer 12 90.56 High High
Depression 4 82.08 Quite High
Pain 1 75.00 Quite High
Cardiovascular Disorder Under Development 8 59.60 Quite High
Stroke 4 18.72 Low Low
Cv Unclassified Under Development 4 17.28 Low Low
Heart Rate Under Development 4 14.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When expressed in COS-7 cells, the 5-HT5B receptor displayed a high affinity for the serotonergic radioligand 125I-lysergic acid diethylamide.
Gene_expression (expressed) of 5-HT5B
1) Confidence 0.75 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8450829 Disease Relevance 0 Pain Relevance 0.29
In situ hybridization experiments revealed that the 5-HT5B mRNA was expressed predominantly in the habenula and in the CA1 field of the hippocampus.
Gene_expression (expressed) of 5-HT5B in hippocampus associated with hippocampus
2) Confidence 0.65 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8450829 Disease Relevance 0 Pain Relevance 0.34
Thirty-eight AA-5-HT analogues, containing a serotonin "head" bound to a variety of lipophilic moieties via amide, urea, or carbamate functionalities, were synthesized.
Gene_expression (synthesized) of AA-5-HT in head associated with serotonin
3) Confidence 0.07 Published 2007 Journal J. Med. Chem. Section Abstract Doc Link 18027904 Disease Relevance 0.07 Pain Relevance 0.41
Moreover, platelet 5-HT and plasma 5-HIAA levels were highly correlated (P<0.001, not shown) with both platelet MAO activities and protein concentration.
Gene_expression (levels) of platelet 5-HT in plasma
4) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 1.32 Pain Relevance 0
Only FS platelets had lower levels of 5-HT, a finding consistent with the deficiency of the vesicular monoamine transporter reported in platelets of smokers [31] leading to a platelet dense granule 5-HT storage defect.
Gene_expression (levels) of 5-HT in platelet associated with nicotine addiction and monoamine
5) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 0.84 Pain Relevance 0.05
High 5-HT levels have been proposed to be predictive of coronary artery diseases, especially in young people [5].
Gene_expression (levels) of 5-HT in coronary artery associated with coronary artery disease
6) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 0.34 Pain Relevance 0.20
Once synthesized in the gastrointestinal tract, peripheral 5-HT is actively taken up by platelets which store the amine within their dense granules.
Gene_expression (synthesized) of 5-HT in platelets
7) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 0.18 Pain Relevance 0.17

General Comments

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